Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis

2018 ◽  
Vol 96 (9) ◽  
pp. 929-938 ◽  
Author(s):  
Lixia Gao ◽  
Xiangdong Zhao ◽  
Liwei Lang ◽  
Chloe Shay ◽  
W. Andrew Yeudall ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Neck Squamous Cell Carcinoma ◽  
Oxygen Species ◽  
High Reactive Oxygen Species ◽  
Induced Apoptosis

Reactive oxygen species (ROS) reduce the expression of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells

2010 ◽  
Vol 44 (8) ◽  
pp. 913-924 ◽  
Author(s):  
Yojiro Maehata ◽  
Shigeyuki Ozawa ◽  
Kyo Kobayashi ◽  
Yasumasa Kato ◽  
Fumihiko Yoshino ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Human Head ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Oxygen Species

scholarly journals HOXC6 Is Deregulated in Human Head and Neck Squamous Cell Carcinoma and Modulates Bcl-2 Expression

2012 ◽  
Vol 287 (42) ◽  
pp. 35678-35688 ◽  
Author(s):  
Sung-Min Moon ◽  
Soo-A Kim ◽  
Jung-Hoon Yoon ◽  
Sang-Gun Ahn
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Protein A ◽  
Human Head ◽  
Neck Squamous Cell Carcinoma ◽  
Luciferase Reporter ◽  
Apoptotic Pathway ◽  
Induced Apoptosis

Homeobox C6 (HOXC6) genes belong to the homeoprotein family of transcription factors, which play an important role in morphogenesis and cellular differentiation during embryonic development. The aim of this study was to explore the role of HOXC6 in the regulation of Bcl-2 in human head and neck squamous cell carcinoma (HNSCC). The HOXC6 and Bcl-2 gene were identified as being overexpressed in HNSCC tissue and cell lines. Transfection assays demonstrated that HOXC6 increased the levels of Bcl-2 mRNA and protein. A luciferase reporter assay suggested that HOXC6 induced activity of the Bcl-2 promoter. A series of Bcl-2 promoter deletion mutants were examined and the minimal HOXC6-responsive region was identified to be in the TAAT motif (-420 bp) of the Bcl-2 promoter. Interestingly, the inhibition of HOXC6 using siRNA led to the repression of Bcl-2 expression and induced caspase-3-dependent apoptosis; overexpression of HOXC6 in HNSCC cells increased the resistance to paclitaxel-induced apoptosis. Together, our findings suggest that HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression.

scholarly journals Role of JNK activation in paclitaxel‑induced apoptosis in human head and neck squamous cell carcinoma

2021 ◽  
Vol 22 (4) ◽  
Author(s):  
Yu-Yan Lan ◽  
Ying-Hui Chen ◽  
Cheng Liu ◽  
Kuo-Lung Tung ◽  
Yen-Ting Wu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Neck Squamous Cell Carcinoma ◽  
Induced Apoptosis ◽  
Jnk Activation

scholarly journals Proteasome Inhibitor PS-341 Induces Apoptosis through Induction of Endoplasmic Reticulum Stress-Reactive Oxygen Species in Head and Neck Squamous Cell Carcinoma Cells

2004 ◽  
Vol 24 (22) ◽  
pp. 9695-9704 ◽  
Author(s):  
Andrew Fribley ◽  
Qinghua Zeng ◽  
Cun-Yu Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Neck Squamous Cell Carcinoma ◽  
Oxygen Species

ABSTRACT PS-341, also known as Velcade or Bortezomib, represents a new class of anticancer drugs which has been shown to potently inhibit the growth and/or progression of human cancers, including head and neck squamous cell carcinoma (HNSCC). Although it has been logically hypothesized that NF-κB is a major target of PS-341, the underlying mechanism by which PS-341 inhibits tumor cell growth is unclear. Here we found that PS-341 potently activated the caspase cascade and induced apoptosis in human HNSCC cell lines. Although PS-341 could inhibit NF-κB activation, the inhibition of NF-κB was not sufficient to initiate apoptosis in HNSCC cells. Using biochemical and microarray approaches, we found that proteasome inhibition by PS-341 induced endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in HNSCC cells. The inhibition of ROS significantly suppressed caspase activation and apoptosis induced by PS-341. Consistently, PS-341 could not induce the ER stress-ROS in PS-341-resistant HNSCC cells. Taken together, our results suggest that in addition to the abolishment of the prosurvival NF-κB, PS-341 might directly induce apoptosis by activating proapoptotic ER stress-ROS signaling cascades in HNSCC cells, providing novel insights into the PS-341-mediated antitumor activity.

Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin

2020 ◽  
Author(s):  
Mabel Catalán ◽  
Catalina Rodríguez ◽  
Ivonne Olmedo ◽  
Javiera Carrasco-Rojas ◽  
Diego Rojas ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Cell Lines ◽  
Squamous Cell ◽  
Carcinoma Cell ◽  
Human Head ◽  
Neck Squamous Cell Carcinoma ◽  
Carcinoma Cell Lines
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