Integrated approach to the mechanisms of thyroid toxins: electron transfer, reactive oxygen species, oxidative stress, cell signaling, receptors, and antioxidants

2010 ◽  
Vol 30 (3) ◽  
pp. 133-142 ◽  
Author(s):  
Peter Kovacic ◽  
Corey Edwards
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Electron Transfer ◽  
Cell Signaling ◽  
Reactive Oxygen ◽  
Integrated Approach ◽  
Oxygen Species ◽  
Signaling Receptors

scholarly journals Mechanism of Anesthetic Toxicity: Metabolism, Reactive Oxygen Species, Oxidative Stress, and Electron Transfer

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Peter Kovacic ◽  
Ratnasamy Somanathan
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Electron Transfer ◽  
Adverse Effects ◽  
Molecular Level ◽  
Reactive Oxygen ◽  
Toxic Effects ◽  
Oxygen Species ◽  
Beneficial Effects

There is much literature on the toxic effects of anesthetics. This paper deals with both the volatiles and locals. Adverse effects appear to be multifaceted, with the focus on radicals, oxidative stress (OS), and electron transfer (ET). ET functionalities involved are quinone, iminoquinone, conjugated iminium, and nitrone. The non-ET routes involving radicals and OS apparently pertain to haloalkanes and ethers. Beneficial effects of antioxidants, evidently countering OS, are reported. Knowledge at the molecular level should aid in devising strategies to combat the adverse effects.

scholarly journals Achillolide A Protects Astrocytes against Oxidative Stress by Reducing Intracellular Reactive Oxygen Species and Interfering with Cell Signaling

Molecules ◽  
2016 ◽  
Vol 21 (3) ◽  
pp. 301 ◽  
Author(s):  
Anat Elmann ◽  
Alona Telerman ◽  
Hilla Erlank ◽  
Rivka Ofir ◽  
Yoel Kashman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Cell Signaling ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Oxygen Species
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