Preparation and Characterization of Tablet Formulation based on Solid Dispersion of Glimepiride and Poly(ester amide) Hyperbranched Polymer

2011 ◽  
Vol 18 (2) ◽  
pp. 323-332 ◽  
Author(s):  
Sebastjan Reven ◽  
Miha Homar ◽  
Luka Peternel ◽  
Julijana Kristl ◽  
Ema Žagar
Keyword(s):  
Solid Dispersion ◽  
Hyperbranched Polymer ◽  
Tablet Formulation

Synthesis and characterization of vitamin B12-hyperbranched polymer

2007 ◽  
Vol 48 (29) ◽  
pp. 5065-5068 ◽  
Author(s):  
Keishiro Tahara ◽  
Hisashi Shimakoshi ◽  
Akihiro Tanaka ◽  
Yoshio Hisaeda
Keyword(s):  
Vitamin B12 ◽  
Hyperbranched Polymer ◽  
Synthesis And Characterization

Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation

2021 ◽  
Vol 20 (1) ◽  
pp. 31-39
Author(s):  
Oluyemisi Adebowale Bamiro ◽  
Aishat Oyinkansola Salisu ◽  
Ese Mary Iyere ◽  
Olatundun Atoyegbe ◽  
Olutayo Ademola Adeleye ◽  
...  
Keyword(s):  
Tablet Formulation ◽  
Achatina Fulica ◽  
Flow Properties ◽  
Crushing Strength ◽  
Snail Shell ◽  
Significant Difference ◽  
Swelling Capacity ◽  
Tablet Formulations ◽  
Scanning Electron

The aim of the work was to characterize chitosan extracted from snail shell and evaluate its use as a disintegrant and binder in metronidazole tablet formulation in comparison with standard chitosan (SC). The mechanical properties were assessed using crushing strength and friability, while the release properties were assessed using disintegration and dissolution times. The extracted chitosan (EC) was crystalline in nature and the scanning electron microscopy (SEM) showed polygonal particles with rough surface. The moisture and swelling capacity was 1.80% and 15.00%, respectively. The densities and flow properties were significantly (p<0.05) higher than those of the SC. As a binder, the crushing strength of formulations containing EC was higher than SC, but both formulation failed friability test. There was significant difference between the disintegration times of the metronidazole formulations containing EC and SC as a disintegrant. The result showed that EC is more effective as a binder in tablet formulations. Dhaka Univ. J. Pharm. Sci. 20(1): 31-39, 2021 (June)

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