Vascular β-amyloid in Alzheimer's disease angiopathy is produced by proliferating and degenerating smooth muscle cells

Amyloid ◽  
1994 ◽  
Vol 1 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Henryk M. Wisniewski ◽  
Janusz Fragkowiak ◽  
Albina Zoltowska ◽  
Kwang Soo Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Β Amyloid

β-amyloid context intensifies vascular smooth muscle cells induced inflammatory response and de-differentiation

Aging Cell ◽  
2013 ◽  
Vol 12 (3) ◽  
pp. 358-369 ◽  
Author(s):  
Amélie Vromman ◽  
Nesrine Trabelsi ◽  
Clotilde Rouxel ◽  
Gilbert Béréziat ◽  
Isabelle Limon ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Inflammatory Response ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Β Amyloid

Cytotoxicity of β-amyloid peptide 25–35 on vascular smooth muscle cells and attenuation by vitamin E

1997 ◽  
Vol 33 (9) ◽  
pp. 672-673 ◽  
Author(s):  
Ephraim Tobela Gwebu ◽  
Joanne Williams ◽  
Dwayne Mathis ◽  
Jeannine A. Warden ◽  
Michael Selassie ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vitamin E ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Vascular α1A Adrenergic Receptors as a Potential Therapeutic Target for IPAD in Alzheimer’s Disease

2020 ◽  
Vol 13 (9) ◽  
pp. 261
Author(s):  
Miles Frost ◽  
Abby Keable ◽  
Dan Baseley ◽  
Amber Sealy ◽  
Diana Andreea Zbarcea ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Adrenergic Receptors ◽  
Adrenergic Receptor ◽  
Muscle Cells ◽  
Cerebral Vessels ◽  
Cerebrovascular Smooth Muscle Cells ◽  
The Brain ◽  
Young Old

Drainage of interstitial fluid from the brain occurs via the intramural periarterial drainage (IPAD) pathways along the basement membranes of cerebral capillaries and arteries against the direction of blood flow into the brain. The cerebrovascular smooth muscle cells (SMCs) provide the motive force for driving IPAD, and their decrease in function may explain the deposition of amyloid-beta as cerebral amyloid angiopathy (CAA), a key feature of Alzheimer’s disease. The α-adrenoceptor subtype α1A is abundant in the brain, but its distribution in the cerebral vessels is unclear. We analysed cultured human cerebrovascular SMCs and young, old and CAA human brains for (a) the presence of α1A receptor and (b) the distribution of the α1A receptor within the cerebral vessels. The α1A receptor was present on the wall of cerebrovascular SMCs. No significant changes were observed in the vascular expression of the α1A-adrenergic receptor in young, old and CAA cases. The pattern of vascular staining appeared less punctate and more diffuse with ageing and CAA. Our results show that the α1A-adrenergic receptor is preserved in cerebral vessels with ageing and in CAA and is expressed on cerebrovascular smooth muscle cells, suggesting that vascular adrenergic receptors may hold potential for therapeutic targeting of IPAD.

Factors produced by activated macrophages reduce accumulation of Alzheimer's β-amyloid protein in vascular smooth muscle cells

1997 ◽  
Vol 760 (1-2) ◽  
pp. 255-260 ◽  
Author(s):  
Bozena Mazur-Kolecka ◽  
Janusz Frackowiak ◽  
Harry Le Vine ◽  
Taraneh Haske ◽  
Henryk M Wisniewski
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Amyloid Protein ◽  
Activated Macrophages ◽  
Β Amyloid
Sign in / Sign up

Export Citation Format

Share Document