This chapter is underpinned by the assertion that all people with intellectual disabilities can communicate and may use a wide range of means to do so, including verbal, non-verbal, vocal, and gestural approaches. The behaviour of people with intellectual disabilities is also an important factor in understanding their communication, including behaviours that may be viewed as being a challenge or being of concern. A major problem for many people with intellectual disabilities is having the meaning of their communication understood by other people. This chapter explores the key factors that nurses working with people with intellectual disabilities need to know in relation to effective communication and providing accessible information to people with intellectual disabilities. It provides practical information in the use of augmentative and alternative communication systems, as well as information on communication passports, objects of reference, and compiling life stories.