Long-term damage assessment in patients with microscopic polyangiitis and renal-limited vasculitis using the Vasculitis Damage Index

2013 ◽  
Vol 24 (1) ◽  
pp. 112-119 ◽  
Author(s):  
Mitsuyo Itabashi ◽  
Takashi Takei ◽  
Takahito Moriyama ◽  
Syunji Shiohira ◽  
Ari Shimizu ◽  
...  
Keyword(s):  
Damage Assessment ◽  
Microscopic Polyangiitis ◽  
Damage Index ◽  
Vasculitis Damage Index

Long-term damage assessment in patients with microscopic polyangiitis and renal-limited vasculitis using the Vasculitis Damage Index

2013 ◽  
Author(s):  
Mitsuyo Itabashi ◽  
Takashi Takei ◽  
Takahito Moriyama ◽  
Syunji Shiohira ◽  
Ari Shimizu ◽  
...  
Keyword(s):  
Damage Assessment ◽  
Microscopic Polyangiitis ◽  
Damage Index ◽  
Vasculitis Damage Index

scholarly journals Damage in the anca-associated vasculitides: long-term data from the European Vasculitis Study group (EUVAS) therapeutic trials

2013 ◽  
Vol 74 (1) ◽  
pp. 177-184 ◽  
Author(s):  
Joanna Robson ◽  
Helen Doll ◽  
Ravi Suppiah ◽  
Oliver Flossmann ◽  
Lorraine Harper ◽  
...  
Keyword(s):  
A Priori ◽  
Damage Index ◽  
Study Group ◽  
Therapeutic Trials ◽  
Long Term Follow Up ◽  
Frequent Items ◽  
Vasculitis Damage Index ◽  
Over Time

ObjectivesTo describe short-term (up to 12 months) and long-term (up to 7 years) damage in patients with newly diagnosed antineutrophil-cytoplasm antibody-associated vasculitis (AAV).MethodsData were combined from six European Vasculitis Study group trials (n=735). Long-term follow-up (LTFU) data available for patients from four trials (n=535). Damage accrued was quantified by the Vasculitis Damage Index (VDI). Sixteen damage items were defined a priori as being potentially treatment-related.ResultsVDI data were available for 629 of 735 patients (85.6%) at baseline, at which time 217/629 (34.5%) had ≥1 item of damage and 32 (5.1%) ≥5 items, reflecting disease manifestations prior to diagnosis and trial enrolment. LTFU data were available for 467/535 (87.3%) at a mean of 7.3 years postdiagnosis. 302/535 patients (56.4%) had VDI data at LTFU, with 104/302 (34.4%) having ≥5 items and only 24 (7.9%) no items of damage. At 6 months and LTFU, the most frequent items were proteinuria, impaired glomerular filtration rate, hypertension, nasal crusting, hearing loss and peripheral neuropathy. The frequency of damage, including potentially treatment-related damage, rose over time (p<0.01). At LTFU, the most commonly reported items of treatment-related damage were hypertension (41.5%; 95% CI 35.6 to 47.4%), osteoporosis (14.1%; 9.9 to 18.2%), malignancy (12.6%; 8.6 to 16.6%), and diabetes (10.4%; 6.7 to 14.0%).ConclusionsIn AAV, renal, otolaryngological and treatment-related (cardiovascular, disease, diabetes, osteoporosis and malignancy) damage increases over time, with around one-third of patients having ≥5 items of damage at a mean of 7 years postdiagnosis.

Structural Damage Assessment Using Output-Only Measurement: Localization and Quantification

2013 ◽  
Author(s):  
Chin-Hsiung Loh ◽  
Min-Hsuan Tseng ◽  
Shu-Hsien Chao
Keyword(s):  
Damage Detection ◽  
Damage Assessment ◽  
Structural Damage ◽  
Damage Identification ◽  
Model Updating ◽  
Null Space ◽  
Singular Spectrum Analysis ◽  
Damage Index ◽  
Computation Efficiency ◽  
Output Only

One of the important issues to conduct the damage detection of a structure using vibration-based damage detection (VBDD) is not only to detect the damage but also to locate and quantify the damage. In this paper a systematic way of damage assessment, including identification of damage location and damage quantification, is proposed by using output-only measurement. Four level of damage identification algorithms are proposed. First, to identify the damage occurrence, null-space and subspace damage index are used. The eigenvalue difference ratio is also discussed for detecting the damage. Second, to locate the damage, the change of mode shape slope ratio and the prediction error from response using singular spectrum analysis are used. Finally, to quantify the damage the RSSI-COV algorithm is used to identify the change of dynamic characteristics together with the model updating technique, the loss of stiffness can be identified. Experimental data collected from the bridge foundation scouring in hydraulic lab was used to demonstrate the applicability of the proposed methods. The computation efficiency of each method is also discussed so as to accommodate the online damage detection.

scholarly journals Juvenile Idiopathic Arthritis in Adults: Long-Term Observation of Ukrainian Patients

2017 ◽  
Vol 23 (1) ◽  
Author(s):  
Marta Dzhus
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Rheumatoid Factor ◽  
Rheumatic Diseases ◽  
Damage Index ◽  
Health Assessment ◽  
Juvenile Arthritis ◽  
Adult Age ◽  
Enthesitis Related Arthritis ◽  
Long Term Observation

The assessment of long-term outcome of functional disability and disease activeness in adult patients with juvenile idiopathic arthritis appears to be complicated due to the absence of a unified approach to the classification and estimation of disease activeness, as well as the loss of supervision over a patient because of remission or his/her transition from pediatric to adult rheumatic service. The objective of the research was to determine how adults with the history of juvenile idiopathic arthritis fulfill the classification criteria for adult rheumatic diseases, as well as to assess activeness of these diseases, the degree of functional disorders, and social activeness of patients in Ukraine. Materials and methods. Patients with juvenile idiopathic arthritis older than 18 years and with more than 3 years of disease duration living in different parts of Ukraine were included into the study. Data regarding sociodemographic features, fulfillment of adult classification criteria, Health Assessment Questionnaire, articular and extra-articular Juvenile Arthritis Damage Index and disease activity were analyzed.Results. We observed 122 adult patients with the history of juvenile idiopathic arthritis irrespective of the presence of active inflammation at the moment of the examination. This group included patients from different regions of Ukraine diagnosed with juvenile idiopathic arthritis during 1984-2013. An adult rheumatologist examined all patients and the diagnosis was revised according to the adult classification of rheumatic diseases. Typical diagnostic criteria for rheumatoid arthritis were estimated in 32.8% of patients, ankylosing spondylitis – in 31.1% of patients, undifferentiated arthritis – in 13.9% of patients, Still’s disease – in 4.9% of patients, psoriatic arthritis – in 0.8% of patients, steady clinical laboratory remission – in 16.5% of patients. Most patients (81.8%) with rheumatoid factor positive polyarticular juvenile idiopathic arthritis fell under rheumatoid arthritis criteria in adulthood, and in 85% of patients with enthesitis-related arthritis as well as 53.8% of patients with extended oligoarthritis ankylosing spondylitis developed in adulthood. 68.8% of patients with systemic juvenile idiopathic arthritis, 68% of patients with rheumatoid factor negative polyarthritic subtype and 55% of patients with enthesitis-related arthritis had disability and incapacitation. Minimal disorders of the patients’ general condition according to the Health Assessment Questionnaire in adult age were found in most subtypes of juvenile idiopathic arthritis classified according to the International League of Associations for Rheumatology (extended and persistent oligoarthritis, rheumatoid factor positive polyarthritis, systemic subtype); moderate disorders of the general condition were found in enthesitis-related arthritis and rheumatoid factor negative polyarthritis. Side effects of juvenile idiopathic arthritis according to the articular Juvenile Arthritis Damage Index included severe articular damage being most frequently found in systemic and rheumatoid factor positive polyarthritis subtypes of juvenile idiopathic arthritis, while side effects of juvenile idiopathic arthritis according to the extra-articular Juvenile Arthritis Damage Index included extra-articular damage being found in systemic and rheumatoid factor negative polyarthritis subtypes of juvenile idiopathic arthritis, that was confirmed by the assessment of physical health according to the Short Form Health Survey-36, which was the worst in patients with systemic (40.3±12.6) and rheumatoid factor negative polyarthritis (38.9±9.4) subtypes of juvenile idiopathic arthritis.Conclusions. Further research of remote consequences of juvenile idiopathic arthritis in adult age and long-term observation of such patients require a detailed study to improve diagnostics and provide adequate treatment of rheumatic diseases with juvenile onset in adult age.

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