Classifying neonatal growth outcomes: use of birth weight, placental evaluation and individualized growth assessment

Background: Growth assessment including birth weight, length, and head circumference is important to identify infants at risk. However, using international growth curves may be inappropriate for growth assessment of Thai neonates. Objective: To generate a growth chart of infants at the Phramongkutklao Hospital (PMK), and to compare PMK’s growth chart assessment with other international growth charts. Materials and Methods: The authors generated a PMK growth chart from PMK’s newborn database between 2007 and 2016. Birth weight of infants born in 2017 was assessed by using the PMK growth chart in comparison with the Fenton, Lubchenco and Intergrowth Twenty-first growth charts. Results: To generate a PMK growth chart, 22,926 infants were enrolled to the present study. Comparing with other international growth charts, the Fenton exhibited a higher ninetieth percentile of birth weight than others, especially at gestational age of 36 to 41 weeks. In contrast, the Lubchenco exhibited the lowest tenth percentile of birth weight. In 2017, 2,314 infants were born and evaluated by using the PMK, the Fenton, the Lubchenco, and the Intergrowth-21st growth charts. Large for gestational age (LGA) was identified in 185 (8.64%), 55 (2.57%), 166 (7.75%) and 166 (7.75%) infants, respectively. In contrast, small for gestational age (SGA) was identified in 220 (10.27%), 228 (10.64%), 34 (1.59%) and 148 (6.91%) infants, respectively. The admission rate of infants diagnosed as LGA by PMK, but appropriate for gestational age (AGA) by Fenton was higher than other AGA infants. Conclusion: The PMK reference of neonatal growth is up-to-date and applicable. Growth assessment using the Fenton growth chart at late preterm and term gestations may be inaccurate to identify LGA infants. In contrast, the Lubchenco growth chart has limitation to identify SGA infants. Data accumulation from multi-centers at different regions of Thailand are warranted to generate a Thai neonatal growth reference. Keywords: Growth curve, Neonatal growth, Large for gestational age, Small for gestational age

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OP20.04: The relationship of newborn adiposity to neonatal growth outcome based on birth weight or the neonatal growth assessment score

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.9447 ◽

2011 ◽

Vol 38 (S1) ◽

pp. 114-114

Author(s):

W. Lee ◽

T. Riggs ◽

W. Koo ◽

R. L. Deter ◽

L. Yeo ◽

...

Keyword(s):

Birth Weight ◽

Assessment Score ◽

Neonatal Growth ◽

Relationship Of ◽

The Relationship ◽

Growth Assessment

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The relationship of newborn adiposity to fetal growth outcome based on birth weight or the modified neonatal growth assessment score

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.3109/14767058.2012.683084 ◽

2012 ◽

Vol 25 (10) ◽

pp. 1933-1940 ◽

Cited By ~ 22

Author(s):

Wesley Lee ◽

Thomas Riggs ◽

Winston Koo ◽

Russell L. Deter ◽

Lami Yeo ◽

...

Keyword(s):

Birth Weight ◽

Fetal Growth ◽

Assessment Score ◽

Neonatal Growth ◽

Relationship Of ◽

The Relationship ◽

Growth Assessment

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Single-course antenatal corticosteroids is related to faster growth in very-low-birth-weight infant

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03510-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jiajia Jing ◽

Yiheng Dai ◽

Yanqi Li ◽

Ping Zhou ◽

Xiaodong Li ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Gestational Age ◽

Very Low Birth Weight ◽

Postnatal Growth ◽

Weight Increase ◽

Antenatal Corticosteroids ◽

Lung Maturation ◽

Growth Outcomes

Abstract Background Antenatal corticosteroids (ACS) treatment is critical to support survival and lung maturation in preterm infants, however, its effect on feeding and growth is unclear. Prior preterm delivery, it remains uncertain whether ACS treatment should be continued if possible (repeated course ACS), until a certain gestational age is reached. We hypothesized that the association of single-course ACS with feeding competence and postnatal growth outcomes might be different from that of repeated course ACS in very-low-birth-weight preterm infants. Methods A multicenter retrospective cohort study was conducted in very-low-birth-weight preterm infants born at 23–37 weeks’ gestation in South China from 2011 to 2014. Data on growth, nutritional and clinical outcomes were collected. Repeated course ACS was defined in this study as two or more courses ACS (more than single-course). Infants were stratified by gestational age (GA), including GA < 28 weeks, 28 weeks ≤ GA < 32 weeks and 32 weeks ≤ GA < 37 weeks. Multiple linear regression and multilevel model were applied to analyze the association of ACS with feeding and growth outcomes. Results A total of 841 infants were recruited. The results, just in very-low-birth-weight preterm infants born at 28–32 weeks’ gestation, showed both single and repeated course of ACS regimens had shorter intubated ventilation time compared to non-ACS regimen. Single-course ACS promoted the earlier application of amino acid and enteral nutrition, and higher rate of weight increase (15.71; 95%CI 5.54–25.88) than non-ACS after adjusting for potential confounding factors. No associations of repeated course ACS with feeding, mean weight and weight increase rate were observed. Conclusions Single-course ACS was positively related to feeding and growth outcomes in very-low-birth-weight preterm infants born at 28–32 weeks’ gestation. However, the similar phenomenon was not observed in the repeated course of ACS regimen.

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Correlation of serum adiponectin and leptin concentrations with anthropometric parameters in newborns

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1210595p ◽

2012 ◽

Vol 140 (9-10) ◽

pp. 595-599 ◽

Cited By ~ 13

Author(s):

Snezana Palcevska-Kocevska ◽

Natasa Aluloska ◽

Marija Krstevska ◽

Elena Shukarova-Angelovska ◽

Ljiljana Kojik ◽

...

Keyword(s):

Birth Weight ◽

Growth Regulation ◽

Physiological Role ◽

Mutual Relationship ◽

Anthropometric Parameters ◽

Serum Leptin ◽

Significant Difference ◽

Neonatal Growth ◽

Singleton Pregnancies

Introduction. It has been shown that some adipocytokines and their mutual relationship can be indicators of fetal and neonatal growth. Physiological role of leptin and adiponectin in fetal and neonatal growth is not well established. Objectives. The aim of this study was to assess the correlation of the anthropometrics parameters and serum concentration of leptin and adiponectin levels in healthy newborns. Methods. A cohort of 110 neonates, born after uncomplicated singleton pregnancies at term, were classified as AGA (n=60), SGA (n=30) and LGA (n=20) according to the Lubchenco curves. Anthropometric parameters of the neonates: birth weight (BW), birth length (BL), body weight/body length ratio (BW/ BL), Body Mass Index (BMI) and Ponderal Index (PI) were recorded after birth. Results. Mean serum leptin and adiponectin levels in both sexes were not significantly different (male: 1.85?0.75; 29.51?22.89 and female: 2.06?0.99; 31.60?23.51 ng/mL). There was a significant difference between leptin levels in AGA and LGA newborns (1.93?0.84 vs. 3.12?1.50 ng/mL) (p<0.05), and in adiponectin levels between AGA and LGA compared to SGA newborns (32.8?23.29 and 43.40?31.24 vs. 12.67?2.43 ng/mL, respectivel; p<0.05; p<0.05). Leptin and adiponectin levels were positively correlated with BW (r=0.63 and r=0.41), BL (r=0.63, r=0.42), BW/BL (r=0.61, r=0.41), BMI (r=0.54, r=0.35), and PI (r=0.47, r=0.29, (p<0.01). Conclusion. Significantly higher adiponectin levels were found in AGA neonates compared to SGA neonates. Leptin and adiponectine levels were positively correlated with birth weight. These findings suggest that these adipocytokines may be involved in fetal growth regulation.

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