scholarly journals Correlation of serum adiponectin and leptin concentrations with anthropometric parameters in newborns

2012 ◽  
Vol 140 (9-10) ◽  
pp. 595-599 ◽  
Author(s):  
Snezana Palcevska-Kocevska ◽  
Natasa Aluloska ◽  
Marija Krstevska ◽  
Elena Shukarova-Angelovska ◽  
Ljiljana Kojik ◽  
...  
Keyword(s):  
Birth Weight ◽  
Growth Regulation ◽  
Physiological Role ◽  
Mutual Relationship ◽  
Anthropometric Parameters ◽  
Serum Leptin ◽  
Significant Difference ◽  
Neonatal Growth ◽  
Singleton Pregnancies

Introduction. It has been shown that some adipocytokines and their mutual relationship can be indicators of fetal and neonatal growth. Physiological role of leptin and adiponectin in fetal and neonatal growth is not well established. Objectives. The aim of this study was to assess the correlation of the anthropometrics parameters and serum concentration of leptin and adiponectin levels in healthy newborns. Methods. A cohort of 110 neonates, born after uncomplicated singleton pregnancies at term, were classified as AGA (n=60), SGA (n=30) and LGA (n=20) according to the Lubchenco curves. Anthropometric parameters of the neonates: birth weight (BW), birth length (BL), body weight/body length ratio (BW/ BL), Body Mass Index (BMI) and Ponderal Index (PI) were recorded after birth. Results. Mean serum leptin and adiponectin levels in both sexes were not significantly different (male: 1.85?0.75; 29.51?22.89 and female: 2.06?0.99; 31.60?23.51 ng/mL). There was a significant difference between leptin levels in AGA and LGA newborns (1.93?0.84 vs. 3.12?1.50 ng/mL) (p<0.05), and in adiponectin levels between AGA and LGA compared to SGA newborns (32.8?23.29 and 43.40?31.24 vs. 12.67?2.43 ng/mL, respectivel; p<0.05; p<0.05). Leptin and adiponectin levels were positively correlated with BW (r=0.63 and r=0.41), BL (r=0.63, r=0.42), BW/BL (r=0.61, r=0.41), BMI (r=0.54, r=0.35), and PI (r=0.47, r=0.29, (p<0.01). Conclusion. Significantly higher adiponectin levels were found in AGA neonates compared to SGA neonates. Leptin and adiponectine levels were positively correlated with birth weight. These findings suggest that these adipocytokines may be involved in fetal growth regulation.

The role of photoperiod on the expression of hypothalamic genes regulating appetite in Chevrier’s field mouse (Apodemus chevrieri)

2015 ◽  
Vol 65 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Lin Zhang ◽  
Fang Yang ◽  
Jinhong Cai ◽  
Chunmei Huang ◽  
Zhengkun Wang ◽  
...  
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Mrna Expression ◽  
Physiological Role ◽  
Field Mouse ◽  
Related Protein ◽  
Serum Leptin ◽  
Significant Difference ◽  
Agouti Related Protein

The hypothalamus and leptin play a key role in the regulation of food intake. The present study investigated the effects of 4 weeks of short- or long-photoperiod on serum leptin levels and food intake in relation to mRNA expression levels of neuropeptide Y, agouti-related protein, pro-opiomelanocortin, and cocaine- and amphetamine-regulated transcript in the hypothalamus of Chevrier’s field mouse (Apodemus chevrieri). There was a significant difference in body fat mass, food intake and neuropeptide Y mRNA expression between the two groups, but serum leptin level, agouti-related protein, pro-opiomelanocortin, and cocaine- and amphetamine-regulated transcript mRNA expression in the hypothalamus were not difference between the two groups. The elevation of neuropeptide Y mRNA regulated neuropeptides in the hypothalamus suggests a physiological role of neuroendocrine factors in food intake during the different photoperiod. We conclude that leptin may be involved in energy balance and body mass regulation.

Relationship between Leptin Concentration in Cord Blood and Foetal Growth and Maternal Anthropometry of GDM Mothers at Delivery

1970 ◽  
Vol 25 (1) ◽  
pp. 9-13
Author(s):  
S Jahan ◽  
TR Das ◽  
KB Biswas
Keyword(s):  
Body Mass Index ◽  
Birth Weight ◽  
Cord Blood ◽  
Body Mass ◽  
Anthropometric Measurements ◽  
Anthropometric Parameters ◽  
Serum Leptin ◽  
C Peptide ◽  
Cord Serum ◽  
The Relationship

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)

scholarly journals Relationship between serum leptin levels, non-cardiovascular risk factors and mortality in hemodialysis patients

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ivona Risovic ◽  
Vlastimir Vlatkovic ◽  
Snjezana Popovicpejicic ◽  
Gabrijela Malešević
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Survival Rates ◽  
Inverse Correlation ◽  
Study Groups ◽  
Mineral And Bone Disorder ◽  
Serum Leptin ◽  
Significant Difference

Abstract Introduction. Hemodialysis (HD) patients have higher mortality rate than the general population. Recent studies indicate a significant role of non-cardiovascular risk factors in for mortality in HD patients. Leptin is protein hormone and may indicate malnutrition in HD patients. Its role in mortality in these patients is being examined. This study aimed to investigate the correlation between serum leptin levels and non-cardiovascular risk factors and relationship between leptin level and mortality in HD patients. Methods The prospective study included 93 patients on maintenance HD and follow-up period was 12 months. We measured leptin level and evaluated non-cardiovascular risk factors: nutritional status, anemia, volemia, parameters of mineral and bone disorder. Results. Out of 93 patients 9 died during study and 1 underwent kidney transplantation. Malnutrition and hypervolemia were two main non-cardiovascular risk factors among deceased subjects. Leptin showed a significant direct correlation with nutritional BMI (r = 0.72, P <0.001), fat tissue index (r = 0.74, P <0.001) and statistically significant inverse correlation with leantissue index (r = -0.349, P <0.05) and inverse correlation with volemic parameters (overhydration / extracellular water ratio (r = -0.38, P <0.001), but no association with anemia and mineral bone parameters was observed. Elevated leptin levels were associated with better survival. However, no statistically significant difference in survival rates was observed between the study groups (Log-Rank P =0.214, Breslow P =0.211, Tarone-Ware P=0.212). Conclusion: Deceased patients had significantly lower leptin values. Leptin was associated with two non-cardiovascular risk factors for mortality: malnutrition and hypervolemia.

scholarly journals Prevalence, Pattern and Risk Factors of Severe Acute Malnutrition in Children below Six Months Old in Jos North Central Nigeria

2020 ◽  
Vol 3 (1) ◽  
pp. 212-216
Author(s):  
C John ◽  
R Adah ◽  
R Caleb ◽  
S Okolo
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Severe Acute Malnutrition ◽  
Economic Status ◽  
Acute Malnutrition ◽  
Health Concern ◽  
Older Children ◽  
Anthropometric Parameters ◽  
Significant Difference ◽  
Nutritional Data

Severe Acute Malnutrition (SAM) in infants of less than 6 months of age (U6m) is a serious public health concern globally, especially with declined rates of exclusive breastfeeding. With challenges in the use of the standard anthropometric parameters and higher mortality in these infants than in older children, it is pertinent to document the burden, pattern and risk factors for SAM in U6m. This study aimed to determine the prevalence of SAM in U6m, the pattern and the determinants of malnutrition using weight-for-length (WFL) Z score and mid-upper arm circumference (MUAC), and also to determine the usability of MUAC and WFL in detection of SAM in U6m. Infants six weeks to <6months were recruited. Socio-demographic and nutritional data were collected using researcher administered questionnaire. WFL z scores <-3 and MUAC <11.5cm were used to define SAM. Of the 233 infants aged<6months, mean age was 90.0±38.3days. Females accounted for 52.8%. Nineteen, (8.5%), were born with low birth weight and 11.7% were preterm deliveries. Males had higher mean length for age and weight for age than females but MUAC showed no significant difference. The prevalence of SAM was 2.6% by MUAC and WFL parameters but MUAC identified more SAM subjects in those <3months while WFL identified more in older children. Concordance between MUAC and WFL was poor. Both MUAC and WFL showed more female children than males with MAM. Lower social economic status was significantly associated with SAM while birth weight, birth order, maternal nutritional status and time of first feed did not affect prevalence of SAM in any of the parameters. It is recommended that both WFL and MUAC be employed in the screening of acute malnutrition in this U6m.

scholarly journals Prevalence, Pattern and Risk Factors of Severe Acute Malnutrition in Children below Six Months Old in Jos North Central Nigeria

2020 ◽  
Vol 3 (1) ◽  
pp. 212-216
Author(s):  
C John ◽  
R Adah ◽  
R Caleb ◽  
S Okolo
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Severe Acute Malnutrition ◽  
Economic Status ◽  
Acute Malnutrition ◽  
Health Concern ◽  
Older Children ◽  
Anthropometric Parameters ◽  
Significant Difference ◽  
Nutritional Data

Severe Acute Malnutrition (SAM) in infants of less than 6 months of age (U6m) is a serious public health concern globally, especially with declined rates of exclusive breastfeeding. With challenges in the use of the standard anthropometric parameters and higher mortality in these infants than in older children, it is pertinent to document the burden, pattern and risk factors for SAM in U6m. This study aimed to determine the prevalence of SAM in U6m, the pattern and the determinants of malnutrition using weight-for-length (WFL) Z score and mid-upper arm circumference (MUAC), and also to determine the usability of MUAC and WFL in detection of SAM in U6m. Infants six weeks to <6months were recruited. Socio-demographic and nutritional data were collected using researcher administered questionnaire. WFL z scores <-3 and MUAC <11.5cm were used to define SAM. Of the 233 infants aged<6months, mean age was 90.0±38.3days. Females accounted for 52.8%. Nineteen, (8.5%), were born with low birth weight and 11.7% were preterm deliveries. Males had higher mean length for age and weight for age than females but MUAC showed no significant difference. The prevalence of SAM was 2.6% by MUAC and WFL parameters but MUAC identified more SAM subjects in those <3months while WFL identified more in older children. Concordance between MUAC and WFL was poor. Both MUAC and WFL showed more female children than males with MAM. Lower social economic status was significantly associated with SAM while birth weight, birth order, maternal nutritional status and time of first feed did not affect prevalence of SAM in any of the parameters. It is recommended that both WFL and MUAC be employed in the screening of acute malnutrition in this U6m.

Vascular development in chick embryos: a possible role for adenosine

1989 ◽  
Vol 256 (1) ◽  
pp. H240-H246 ◽  
Author(s):  
T. H. Adair ◽  
J. P. Montani ◽  
D. M. Strick ◽  
A. C. Guyton
Keyword(s):  
Growth Regulation ◽  
Vascular System ◽  
Biological Effects ◽  
Physiological Role ◽  
Ringer Solution ◽  
Whole Body ◽  
Chick Embryos ◽  
Endogenous Adenosine ◽  
Maximum Decrease

We studied the possible role of adenosine in the development of the vasculature using 217 chick embryos. Adenosine (2-32 mumol/day), inosine (16 mumol/day), dipyridamole (0.04-0.4 mumol/day), or aminophylline (400 and 800 micrograms/day) were administered twice each day into the air space on days 11-14. Control embryos received Ringer solution. Whole body vascularity was estimated on day 15 as the whole body structural vascular resistance (SVR), i.e., the hydraulic resistance of the maximally dilated vasculature. Adenosine decreased the SVR in a dose-related manner at the lower dosage amounts but caused a maximum decrease in SVR at the higher dosage amounts averaging 30% below the Ringer control values. Equimolar amounts of adenosine and inosine decreased the SVR by the same extent. Dipyridamole, which potentiates the biological effects of endogenous adenosine, also decreased the SVR in a dose-related manner to values averaging approximately 30% below control. When the effects of endogenous adenosine were blocked by aminophylline, the SVR increased in a dose-related manner to approximately 100% above control at the highest dosage amount. These results suggest that adenosine could have a physiological role in growth regulation of the vascular system in the chick embryo.

scholarly journals Circulating leptin concentrations and ovarian function in polycystic ovary syndrome

2001 ◽  
pp. 289-294 ◽  
Author(s):  
IR Pirwany ◽  
R Fleming ◽  
N Sattar ◽  
IA Greer ◽  
AM Wallace
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ovarian Function ◽  
Polycystic Ovary ◽  
Ovarian Dysfunction ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Serum Leptin ◽  
Significant Difference ◽  
The Relationship

OBJECTIVE: Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction. Although the role of leptin in the control of reproduction is unclear, it may be involved in the control of ovulation. The aim of this cross-sectional study was to determine the relationship between circulating leptin concentrations, and anthropometric, metabolic and endocrine variables as well as to examine a possible role of leptin in ovarian dysfunction associated with PCOS. DESIGN: Prospective observational study. METHODS: Seventy-one subjects with PCOS and 23 body mass index (BMI)-matched control subjects were recruited from infertility clinics. The association between serum leptin concentrations and the above variables was measured outwith the luteal phase. A subgroup of 24 PCOS subjects underwent more frequent blood sampling to monitor follicular growth and ovulation. The association between variables was measured by univariate, multivariate and partial correlation analyses. RESULTS: Serum leptin concentrations were not different in subjects with PCOS and controls, and were strongly associated with BMI in both groups. Twelve patients ovulated during the study period. There was no significant difference in serum leptin concentrations between ovulatory and anovulatory subjects. The relationship between BMI and leptin was similar in both groups. CONCLUSION: The results indicated that circulating leptin concentrations relate principally to total body fat in subjects with PCOS and controls, and that this is not associated with the facility for follicular development and ovulation in these patients.

scholarly journals Prevalence, Pattern and Risk Factors of Severe Acute Malnutrition in Children below Six Months Old in Jos North Central Nigeria

2020 ◽  
Vol 3 (1) ◽  
pp. 212-216
Author(s):  
C John ◽  
R Adah ◽  
R Caleb ◽  
S Okolo
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Severe Acute Malnutrition ◽  
Economic Status ◽  
Acute Malnutrition ◽  
Health Concern ◽  
Older Children ◽  
Anthropometric Parameters ◽  
Significant Difference ◽  
Nutritional Data

Severe Acute Malnutrition (SAM) in infants of less than 6 months of age (U6m) is a serious public health concern globally, especially with declined rates of exclusive breastfeeding. With challenges in the use of the standard anthropometric parameters and higher mortality in these infants than in older children, it is pertinent to document the burden, pattern and risk factors for SAM in U6m. This study aimed to determine the prevalence of SAM in U6m, the pattern and the determinants of malnutrition using weight-for-length (WFL) Z score and mid-upper arm circumference (MUAC), and also to determine the usability of MUAC and WFL in detection of SAM in U6m. Infants six weeks to <6months were recruited. Socio-demographic and nutritional data were collected using researcher administered questionnaire. WFL z scores <-3 and MUAC <11.5cm were used to define SAM. Of the 233 infants aged<6months, mean age was 90.0±38.3days. Females accounted for 52.8%. Nineteen, (8.5%), were born with low birth weight and 11.7% were preterm deliveries. Males had higher mean length for age and weight for age than females but MUAC showed no significant difference. The prevalence of SAM was 2.6% by MUAC and WFL parameters but MUAC identified more SAM subjects in those <3months while WFL identified more in older children. Concordance between MUAC and WFL was poor. Both MUAC and WFL showed more female children than males with MAM. Lower social economic status was significantly associated with SAM while birth weight, birth order, maternal nutritional status and time of first feed did not affect prevalence of SAM in any of the parameters. It is recommended that both WFL and MUAC be employed in the screening of acute malnutrition in this U6m.

scholarly journals Prevalence, Pattern and Risk Factors of Severe Acute Malnutrition in Children below Six Months Old in Jos North Central Nigeria

2020 ◽  
Vol 3 (1) ◽  
pp. 212-216
Author(s):  
C John ◽  
R Adah ◽  
R Caleb ◽  
S Okolo
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Severe Acute Malnutrition ◽  
Economic Status ◽  
Acute Malnutrition ◽  
Health Concern ◽  
Older Children ◽  
Anthropometric Parameters ◽  
Significant Difference ◽  
Nutritional Data

Severe Acute Malnutrition (SAM) in infants of less than 6 months of age (U6m) is a serious public health concern globally, especially with declined rates of exclusive breastfeeding. With challenges in the use of the standard anthropometric parameters and higher mortality in these infants than in older children, it is pertinent to document the burden, pattern and risk factors for SAM in U6m. This study aimed to determine the prevalence of SAM in U6m, the pattern and the determinants of malnutrition using weight-for-length (WFL) Z score and mid-upper arm circumference (MUAC), and also to determine the usability of MUAC and WFL in detection of SAM in U6m. Infants six weeks to <6months were recruited. Socio-demographic and nutritional data were collected using researcher administered questionnaire. WFL z scores <-3 and MUAC <11.5cm were used to define SAM. Of the 233 infants aged<6months, mean age was 90.0±38.3days. Females accounted for 52.8%. Nineteen, (8.5%), were born with low birth weight and 11.7% were preterm deliveries. Males had higher mean length for age and weight for age than females but MUAC showed no significant difference. The prevalence of SAM was 2.6% by MUAC and WFL parameters but MUAC identified more SAM subjects in those <3months while WFL identified more in older children. Concordance between MUAC and WFL was poor. Both MUAC and WFL showed more female children than males with MAM. Lower social economic status was significantly associated with SAM while birth weight, birth order, maternal nutritional status and time of first feed did not affect prevalence of SAM in any of the parameters. It is recommended that both WFL and MUAC be employed in the screening of acute malnutrition in this U6m.

scholarly journals Role of Leptin in Febrile Urinary Tract Infection

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Abolfazl Mahyar ◽  
Parviz Ayazi ◽  
Behnor Hanafizadeh ◽  
Banafsheh Arad ◽  
Reza Dalirani ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
C Reactive Protein ◽  
Febrile Urinary Tract Infection ◽  
Serum Leptin ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Significant Difference ◽  
Febrile Uti

Background: Leptin is a hormone that plays an important role in human health against infections. Some studies have reported that leptin acts as a reactant phase marker in some infectious diseases. The role of leptin in febrile urinary tract infection (UTI) has not been adequately evaluated. Objectives: This study was conducted to determine the role of serum leptin in febrile UTI in children. Methods: Thirty-nine febrile UTI patients were compared with 40 healthy children for the serum leptin level. Serum leptin was measured by the enzyme-linked immunosorbent assay method. The results were compared between the groups. Results: Median (IQR) of serum leptin in the case and control groups was 2 ng/mL and 0.6 ng/mL, respectively. A significant difference was observed between the groups in the serum leptin level (P = 0.001). No significant difference was observed between cystitis and acute pyelonephritis patients in the serum leptin level. The correlation analysis showed no significant association between the serum leptin level and acute-phase reactant markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (r = -0.13 and P = 0.41; r = -0.15 and P = 0.36, respectively). Conclusions: The present study showed that although serum leptin increases in febrile UTI, this increase is not correlated with C-reactive protein and erythrocyte sedimentation rate. Also, this marker cannot discriminate between cystitis and acute pyelonephritis.

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