The effects of 15 Hz trans-spinal magnetic stimulation on locomotor control in mice with chronic contusive spinal cord injury

2013 ◽  
Vol 32 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Michael Leydeker ◽  
Stanley Delva ◽  
Igor Tserlyuk ◽  
Joseph Yau ◽  
Mekhael Wagdy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Magnetic Stimulation ◽  
Locomotor Control ◽  
Cord Injury ◽  
Contusive Spinal Cord Injury

An intracortical neuroprosthesis immediately alleviates walking deficits and improves recovery of leg control after spinal cord injury

2021 ◽  
Vol 13 (586) ◽  
pp. eabb4422
Author(s):  
Marco Bonizzato ◽  
Marina Martinez
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pattern Generation ◽  
Rhythmic Pattern ◽  
Cortical Control ◽  
Motor Mapping ◽  
Cortical Motor ◽  
Locomotor Control ◽  
Cord Injury

Most rehabilitation interventions after spinal cord injury (SCI) only target the sublesional spinal networks, peripheral nerves, and muscles. However, mammalian locomotion is not a mere act of rhythmic pattern generation. Recovery of cortical control is essential for voluntary movement and modulation of gait. We developed an intracortical neuroprosthetic intervention to SCI, with the goal to condition cortical locomotor control. Neurostimulation delivered in phase coherence with ongoing locomotion immediately alleviated primary SCI deficits, such as leg dragging, in rats with incomplete SCI. Cortical neurostimulation achieved high fidelity and markedly proportional online control of leg trajectories in both healthy and SCI rats. Long-term neuroprosthetic training lastingly improved cortical control of locomotion, whereas short training held transient improvements. We performed longitudinal awake cortical motor mapping, unveiling that recovery of cortico-spinal transmission tightly parallels return of locomotor function in rats. These results advocate directly targeting the motor cortex in clinical neuroprosthetic approaches.

scholarly journals Efficacy of functional magnetic stimulation in neurogenic bowel dysfunction after spinal cord injury

2009 ◽  
Vol 41 (1) ◽  
pp. 41-47 ◽  
Author(s):  
PY Tsai ◽  
CP Wang ◽  
FY Chiu ◽  
YA Tsai ◽  
YC Chang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Magnetic Stimulation ◽  
Bowel Dysfunction ◽  
Cord Injury ◽  
Neurogenic Bowel

scholarly journals LOTUS Inhibits Neuronal Apoptosis and Promotes Tract Regeneration in Contusive Spinal Cord Injury Model Mice

eNeuro ◽  
2018 ◽  
Vol 5 (5) ◽  
pp. ENEURO.0303-18.2018 ◽  
Author(s):  
Shuhei Ito ◽  
Narihito Nagoshi ◽  
Osahiko Tsuji ◽  
Shinsuke Shibata ◽  
Munehisa Shinozaki ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Apoptosis ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury ◽  
Contusive Spinal Cord Injury
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