Gallic Acid Ameliorates Cyclophosphamide-Induced Neurotoxicity in Wistar Rats Through Free Radical Scavenging Activity and Improvement in Antioxidant Defense System

2015 ◽  
Vol 13 (4) ◽  
pp. 402-419 ◽  
Author(s):  
Ademola Adetokunbo Oyagbemi ◽  
Temidayo Olutayo Omobowale ◽  
Adebowale Bernard Saba ◽  
Ebunoluwa Racheal Olowu ◽  
Racheal Omolola Dada ◽  
...  
Keyword(s):  
Free Radical ◽  
Gallic Acid ◽  
Wistar Rats ◽  
Antioxidant Defense ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antioxidant Defense System ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Defense System

scholarly journals EVALUATION OF PHYTOCONSTITUENTS, AND ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF JUGLANS REGIA FROM KASHMIR REGION

2019 ◽  
pp. 89-92
Author(s):  
ISHFAQ KHAN ◽  
NEHA CHAUHAN ◽  
CHAUHAN PK ◽  
MOHD. AZHAR KHAN
Keyword(s):  
Free Radical ◽  
Gallic Acid ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Oral Bacteria ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Total Phenolic ◽  
Scavenging Activity ◽  
Standard Curve

Objectives: The main focus of the present study was to evaluate the antimicrobial efficacy (against oral pathogenic bacteria), free radical scavenging activity, and total phenolic and flavonoids content (TPC and TFC) of methanolic extract (ME) of J. regia obtained from Kashmir region. Methods: The plant part was collected and its ME was prepared. ME was subjected to antibacterial activity against oral bacteria such as Staphylococcus aureus, Streptococcus mutans, and Pseudomonas aeruginosa. The free radical scavenging activity was determined using 2,2-diphenyl- 1-picrylhydrazylhydrate (DPPH) assay. TPC and TFC were also determined using a standard curve equation of gallic acid and quercetin. A standard curve using different concentrations of gallic acid and quercetin was drawn from which the concentration of phenols in the test sample was calculated and expressed in mg/g. Results: The ME of J. regia was found effective against all the strains of microorganisms responsible for oral infection understudy. It was also observed that scavenging of DPPH increased with the increase in concentration for both standard ascorbic and methanolic bark extract of J. regia showing its antioxidant potential. The TPC and TFC of ME was found to be 43.35±0.079 and 17.28±0.125. Conclusions: The results obtained from the study clearly indicate that the walnut bark from Kashmir region can be a good candidate for employment as an antibacterial against oral pathogens. J. regia bark was found to be a good source of healthy compounds such as phenolic and flavonoids, suggesting that its bark could be useful to prevent diseases in which free radicals are present.

scholarly journals Antioxidant property and polyphenols evaluation of aqueous root extract of Decalepis hamiltonii Wight & Arn.

1970 ◽  
Vol 1 (4) ◽  
pp. 71-76 ◽  
Author(s):  
Ponnusamy Samydurai ◽  
Vellaichamy Thangapandian
Keyword(s):  
Free Radical ◽  
Gallic Acid ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Root Extract ◽  
Scavenging Activity ◽  
Antioxidant Power ◽  
Decalepis Hamiltonii

Antioxidant activity, total phenol and flavonoids estimation of the aqueous extract of the tuberous root of Decalepis hamiltonii was evaluated by free radical scavenging activity using 2,2-diphenylpicryl-1-picrylhydrazyl (DPPH), metal chelating activity, superoxide scavenging activity, ferric reducing antioxidant power assay (FRAP) and 2,2'azinobis (3-ethylbenzothiozoline-6-sulfonic acid) disodium salt (ABTS•+) assay. The content of polyphenols in the extract was determined by spectrophotometrically, calculated as gallic acid and catechin equivalent. The present investigation revealed that this plant has rich source of antioxidant properties. Naturally, tuber of this plant has been traditionally used as food by the tribal communities. Hence it is inferred that this plant is not only being as food and it can also be a good source of health tonic.Key Words: Decalepis hamiltonii; free radical scavenging activity; gallic acid; catechinDOI: http://dx.doi.org/10.3329/icpj.v1i4.10061International Current Pharmaceutical Journal 2012, 1(4): 71-76

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