Lactate concentration and acid-base balance during haemofiltration with lactate-buffered fluid

1995 ◽  
Vol 6 (6) ◽  
pp. 278-282 ◽  
Author(s):  
A N THOMAS ◽  
J M GUY ◽  
R KISHEN ◽  
B J M BOWLES ◽  
P VADGAMA
Keyword(s):  
Lactate Concentration ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

Acid-Base Balance with Different Capd Solutions

1996 ◽  
Vol 16 (1_suppl) ◽  
pp. 126-129 ◽  
Author(s):  
Mariano Feriani ◽  
Claudio Ronco ◽  
Giuseppe La Greca
Keyword(s):  
Acid Production ◽  
Dwell Time ◽  
Lactate Concentration ◽  
The Body ◽  
Plasma Lactate ◽  
Acid Base Balance ◽  
Bicarbonate Concentration ◽  
Acid Base ◽  
Plasma Bicarbonate ◽  
Base Balance

Our objective is to investigate transperitoneal buffer fluxes with solution containing lactate and bicarbonate, and to compare the final effect on body base balance of the two solutions. One hundred and four exchanges, using different dwell times, were performed in 52 stable continuous ambulatory peritoneal dialysis (CAPD) patients. Dialysate effluent lactate and bicarbonate and volumes were measured. Net dialytic base gain was calculated. Patients’ acid-base status and plasma lactate were determined. In lactate-buffered CAPD solution, lactate concentration in dialysate effluent inversely correlated with length of dwell time, but did not correlate with plasma lactate concentration and net ultrafiltration. Bicarbonate concentration in dialysate effluent correlated with plasma bicarbonate and dwell time but not with ultrafiltration. The arithmetic sum of the lactate gain and bicarbonate loss yielded the net dialytic base gain. Ultrafiltration was the most important factor affecting net dialytic base gain. A previous study demonstrated that in patients using a bicarbonate-buffered solution the net bicarbonate gain is a function of dwell time, ultrafiltration, and plasma bicarbonate. By combining the predicted data of the dialytic base gain with the calculated metabolic acid production, an approximate body base balance could be obtained with both lactate and bicarbonate-buffered CAPD solutions. The body base balance in CAPD patients is self-regulated by the feedback between plasma bicarbonate concentration and dialytic base gain. The level of plasma bicarbonate is determined by the dialytic base gain and the metabolic acid production. This can explain the large interpatient variability in acid-base correction. Bicarbonate-buffered CAPD solution is equal to lactate solution in correcting acid-base disorders of CAPD patients.

Changes in the acid-base balance and lactate concentration in the blood in amateur ultramarathon runners during a 100-km run

2015 ◽  
Vol 32 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Zbigniew Jastrzębski ◽  
Małgorzata Żychowska ◽  
Anna Konieczna ◽  
Wojciech Ratkowski ◽  
Łukasz Radzimiński
Keyword(s):  
Lactate Concentration ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

scholarly journals Effects of NaHCO3 loading on acid-base balance, lactate concentration, and performance in racing greyhounds

1998 ◽  
Vol 85 (3) ◽  
pp. 1037-1043 ◽  
Author(s):  
Lyle D. Kesl ◽  
Richard L. Engen
Keyword(s):  
Base Excess ◽  
Lactate Concentration ◽  
Acid Base Balance ◽  
Acid Base ◽  
Recovery Curves ◽  
Base Balance ◽  
And Performance ◽  
Performance Times ◽  
And Control ◽  
Acid Base Disturbance

This investigation examined the effects of NaHCO3 loading on lactate concentration ([La]), acid-base balance, and performance for a 603.5-m sprint task. Ten greyhounds completed a NaHCO3 (300 mg/kg body weight) and control trial in a crossover design. Results are expressed as means ± SE. Presprint differences ( P < 0.05) were found for NaHCO3 vs. control, respectively, for blood pH (7.47 ± 0.01 vs. 7.42 ± 0.01), [Formula: see text] (28.4 ± 0.4 vs. 23.5 ± 0.3 meq/l), and base excess (5.0 ± 0.3 vs. 0.2 ± 0.3 meq/l). Peak blood [La] increased ( P < 0.05) in NaHCO3 vs. control (20.4 ± 1.6 vs. 16.9 ± 1.3 mM, respectively). Relative to control, NaHCO3 produced a greater ( P < 0.05) reduction in blood base excess (−18.5 ± 1.4 vs. −14.1 ± 0.8 meq/l) and[Formula: see text] (−17.4 ± 1.2 vs. −12.8 ± 0.7 meq/l) from presprint to postexercise. Postexercise peak muscle H+concentration ([H+]) was higher ( P < 0.05) in NaHCO3 vs. control (158.8 ± 8.8 vs. 137.0 ± 5.3 nM, respectively). Muscle [H+] recovery half-time (7.2 ± 1.6 vs. 11.3 ± 1.6 min) and time to predose values (22.2 ± 2.4 vs. 32.9 ± 4.0 min) were reduced ( P < 0.05) in NaHCO3 vs. control, respectively. No differences were found in blood [H+] or blood [La] recovery curves or performance times. NaHCO3 increased postexercise blood [La] but did not reduce the muscle or blood acid-base disturbance associated with a 603.5-m sprint or significantly affect performance.

scholarly journals Prognosis of Hypothermic Patients Undergoing ECLS Rewarming—Do Alterations in Biochemical Parameters Matter?

2021 ◽  
Vol 18 (18) ◽  
pp. 9764
Author(s):  
Hubert Hymczak ◽  
Paweł Podsiadło ◽  
Sylweriusz Kosiński ◽  
Mathieu Pasquier ◽  
Konrad Mendrala ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Lactate Concentration ◽  
Invasive Procedure ◽  
Good Prognosis ◽  
Serum Lactate ◽  
Acid Base Balance ◽  
Acid Base ◽  
Lactate Kinetics ◽  
Base Balance ◽  
The Mean

Background: While ECLS is a highly invasive procedure, the identification of patients with a potentially good prognosis is of high importance. The aim of this study was to analyse changes in the acid-base balance parameters and lactate kinetics during the early stages of ECLS rewarming to determine predictors of clinical outcome. Methods: This single-centre retrospective study was conducted at the Severe Hypothermia Treatment Centre at John Paul II Hospital in Krakow, Poland. Patients ≥18 years old who had a core temperature (Tc) < 30 °C and were rewarmed with ECLS between December 2013 and August 2018 were included. Acid-base balance parameters were measured at ECLS implantation, at Tc 30 °C, and at 2 and 4 h after Tc 30 °C. The alteration in blood lactate kinetics was calculated as the percent change in serum lactate concentration relative to the baseline. Results: We included 50 patients, of which 36 (72%) were in cardiac arrest. The mean age was 56 ± 15 years old, and the mean Tc was 24.5 ± 12.6 °C. Twenty-one patients (42%) died. Lactate concentrations in the survivors group were significantly lower than in the non-survivors at all time points. In the survivors group, the mean lactate concentration decreased −2.42 ± 4.49 mmol/L from time of ECLS implantation until 4 h after reaching Tc 30 °C, while in the non-survivors’ group (p = 0.024), it increased 1.44 ± 6.41 mmol/L. Conclusions: Our results indicate that high lactate concentration is associated with a poor prognosis for hypothermic patients undergoing ECLS rewarming. A decreased value of lactate kinetics at 4 h after reaching 30 °C is also associated with a poor prognosis.

Extreme Derangements of Acid-Base Balance in Exercise: Advantages and Limitations of the Stewart Analysis

1995 ◽  
Vol 20 (3) ◽  
pp. 369-379 ◽  
Author(s):  
M. Roger Fedde ◽  
Richard L. Pieschl Jr.
Keyword(s):  
Dissociation Constants ◽  
Lactate Concentration ◽  
Strong Ion Difference ◽  
Training Methods ◽  
Acid Base Balance ◽  
Acid Base ◽  
Independent Variables ◽  
Base Analysis ◽  
Base Balance ◽  
Weak Electrolytes

The acid-base analysis method described by Stewart (1981) was applied to the greyhound, an animal that undergoes large changes in intra- and extracellular hydrogen ion concentrations during a race. Increases in plasma [H+] especially during the first 15 min of recovery, induced by increases in lactate concentration in the plasma, were reduced by lowering of PCO2 (hyperventilation) and removal of Cl− from the plasma. [H+] calculated by the Stewart method is similar to that measured directly with a pH electrode when the strong ion difference is within 10 meq/L of resting values (≈ 40 meqIL); thus the measured independent variables were sufficient to account for the [H+] using the Stewart analysis. When the strong ion difference became lower than 30 meq/L, increased variability between measured and calculated [H+] occurred. An error analysis demonstrated the importance of minimizing measurement error of all independent variables, including as many strong and weak electrolytes as possible in the analyses, using the most accurate dissociation constants possible, and understanding the dissociation behavior of the weak electrolytes, especially the plasma proteins, when using the Stewart analysis. The Stewart method of analyzing acid-base balance can contribute to improved training methods for obtaining maximum exercise performance. Key words: racing greyhound, sprint exercise, strong ion difference, weak electrolytes

scholarly journals Blood acid-base balance of sportsmen during physical activity

2014 ◽  
Vol 60 (5) ◽  
pp. 591-595 ◽  
Author(s):  
O.P. Petrushova ◽  
N.I. Mikulyak
Keyword(s):  
Physical Activity ◽  
Lactate Concentration ◽  
Respiratory Alkalosis ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Carbon Dioxide Pressure ◽  
Normal Carbon ◽  
Lactate Acidosis ◽  
Postexercise Recovery

The aim of this study was to investigate the acid-base balance parameters in blood of sportsmen by physical activity. Before exercise lactate concentration in blood was normal. Carbon dioxide pressure (рСО2), bicarbonate concentration (НСО3 -), base excess (BE), were increased immediately after physical activity lactate concentration increased, while pH, BE, НСО3 -, рСО2 decreased in capillary blood of sportsmen. These changes show the development of lactate-acidosis which is partly compensated with bicarbonate buffering system and respiratory alkalosis. During postexercise recovery lactate concentration decreased, while рСО2, НСО3 -, BE increased. The results of this study can be used for diagnostics of acid-base disorders and their medical treatment for preservation of sportsmen physical capacity.

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