Application of 3D Printing and Bioprinting Technology to Cleft Lip/Palate Patients

Objective: To determine the current applications of 3-dimensional (3D) printing in the care of patients with cleft lip and palate. We also reviewed 3D printing limitations, financial analysis, and future implications. Design: Retrospective systematic review. Methods: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were used by 3 independent reviewers. Articles were identified from Cochrane library, Ovid Medline, and Embase. Search terms included 3D printing, 3 dimensional printing, additive manufacturing, rapid prototyping, cleft lip, and cleft palate. Exclusion criteria included articles not in English, animal studies, reviews without original data, oral presentations, abstracts, opinion pieces, and articles without relevance to 3D printing or cleft lip and palate. Main Outcome Measures: Primary outcome measure was the purpose of 3D printing in the care of patients with cleft lip and palate. Secondary outcome measures were cost analysis and clinical outcomes. Results: Eight-four articles were identified, and 39 met inclusion/exclusion criteria. Eleven studies used 3D printing models for nasoalveolar molding. Patient-specific implants were developed via 3D printing in 6 articles. Surgical planning was conducted via 3D printing in 8 studies. Eight articles utilized 3D printing for anatomic models/educational purposes. 3-Dimensional printed models were used for surgical simulation/training in 6 articles. Bioprinting was utilized in 4 studies. Secondary outcome of cost was addressed in 8 articles. Conclusion: 3-Dimensional printing for the care of patients with cleft lip and palate has several applications. Potential advantages of utilizing this technology are demonstrated; however, literature is largely descriptive in nature with few clinical outcome measures. Future direction should be aimed at standardized reporting to include clinical outcomes, cost, material, printing method, and results.

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Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2021.111992 ◽

2021 ◽

Vol 142 ◽

pp. 111992

Author(s):

Agnieszka Machorowska-Pieniążek ◽

Tadeusz Morawiec ◽

Marcin Olek ◽

Anna Mertas ◽

David Aebisher ◽

...

Keyword(s):

Oral Cavity ◽

Cleft Lip ◽

Plant Oils ◽

Cleft Lip Palate

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Isoform-Specific Roles of Mutant p63 in Human Diseases

Cancers ◽

10.3390/cancers13030536 ◽

2021 ◽

Vol 13 (3) ◽

pp. 536

Author(s):

Christian Osterburg ◽

Susanne Osterburg ◽

Huiqing Zhou ◽

Caterina Missero ◽

Volker Dötsch

Keyword(s):

Cleft Lip ◽

Ectodermal Dysplasia ◽

Skin Development ◽

Disease Mechanisms ◽

Skin Fragility ◽

Cleft Lip Palate ◽

Life Threatening ◽

Functional Consequences ◽

Development And Differentiation

The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the DNA binding domain cause Ectrodactyly, Ectodermal Dysplasia, characterized by limb deformation, cleft lip/palate, and ectodermal dysplasia while mutations in in the C-terminal domain of the α-isoform cause Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) syndrome, a life-threatening disorder characterized by skin fragility, severe, long-lasting skin erosions, and cleft lip/palate. The molecular disease mechanisms of these syndromes have recently become elucidated and have enhanced our understanding of the role of p63 in epidermal development. Here we review the molecular cause and functional consequences of these p63-mutations for skin development and discuss the consequences of p63 mutations for female fertility.

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Alveolar cleft and maximum cleft width as predictors for difficult laryngoscopy and intubation in patients with unilateral complete cleft lip and palate

Ain-Shams Journal of Anesthesiology ◽

10.1186/s42077-021-00137-7 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Gamal A. Abdelhameed ◽

Wael A. Ghanem ◽

Simon H. Armanios ◽

Tamer Nabil Abdelrahman

Keyword(s):

Body Weight ◽

Odds Ratio ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Difficult Laryngoscopy ◽

Secondary Outcome ◽

Pediatric Airway ◽

Alveolar Cleft ◽

Cleft Lip Palate ◽

Width Measurements

Abstract Background Cleft lip and palate is one of the commonest congenital anomalies, which have an impact on feeding, speech, and dental development away from the significant psychosocial sequel. Early surgical repair aims to restore appearance and function, and the modern techniques can leave many defects undetectable. Therefore, the anesthetic challenge facing the pediatric airway with such abnormalities is still of a great impact. The aim of our study among 189 patients enrolled is to correlate alveolar gap and maximum cleft width measurements as predictors of difficult laryngoscopy and intubation in infants with unilateral complete cleft lip/palate aging from 1 to 6 months. As a secondary outcome, their weight is to be correlated too as another parameter. Results The alveolar gap and maximum cleft width are both of equal high predictive power (p value ≤ 0.001) with 100% sensitivity for both and specificity of 76.10% and 82.39% respectively, with a cut off value of ≤ 10 mm and 11 mm for these dimensions respectively, and odds ratio of incidence of difficult intubation is 4.18 and 5.68 respectively, while body weight ≤ 5.75 kg has an odds ratio of 2.32. Conclusion Alveolar cleft and maximum cleft width can be used as predictors for anticipation of difficult laryngoscopy and intubation infant patients with unilateral complete cleft lip and palate, while body weight ≤ 5.75 kg increases the risk more than twice.

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