scholarly journals Pathogenetic substantiation of diet therapy for Crohn’s disease in children

2021 ◽  
pp. 94-105
Author(s):  
A. I. Khavkin ◽  
T. N. Sorvacheva ◽  
E. A. Roslavtseva
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Nutritional Support ◽  
Intestinal Inflammation ◽  
Bone Mineralization ◽  
Diet Therapy ◽  
Chronic Inflammatory Disease ◽  
Standard Diet ◽  
Newly Diagnosed

Crohn’s disease is a chronic inflammatory disease of the gastrointestinal tract in which patients should receive continuous, lifelong therapy. Particular attention should be paid to their nutritional status. The characteristics of the diet traditionally recommended for Crohn’s disease often lead to a decrease in the consumption of essential nutrients by patients. Therefore, an important role belongs to nutritional support with specialized mixtures, the effectiveness of which has been proven, both for the induction of remission, and for optimizing the parameters of physical development and puberty, bone mineralization. Nutritional support should be carried out in the case of a newly diagnosed disease in the form of complete enteral nutrition, and subsequently - in remission, exacerbation, in the pre- and postoperative periods, as an addition to the standard diet. Of particular interest is the CDED ModuLife program, which is based on a combination of enteral nutrition with specially selected foods, aimed at reducing the activity of intestinal inflammation in CD.

Enteral nutrition for pediatric Crohn’s disease: significance and basic principles

2021 ◽  
Vol 19 (3) ◽  
pp. 70-82
Author(s):  
T.E.Borovik T.E.Borovik ◽  
◽  
A.S.Potapov A.S.Potapov ◽  
E.A.Roslavtseva E.A.Roslavtseva ◽  
A.I.Khavkin A.I.Khavkin ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Nutritional Support ◽  
Intestinal Inflammation ◽  
Bone Mineralization ◽  
Standard Diet ◽  
Newly Diagnosed ◽  
Basic Principles ◽  
Inflammatory Bowel

The characteristics of the diet traditionally recommended for Crohn’s disease often reduce patients’ consumption of essential nutrients. Therefore, an important role belongs to nutritional support with specialized formulas, the effectiveness of which has been proven both for inducing remission and optimizing the parameters of physical development and puberty, bone mineralization. Nutritional support should be provided for patients with newly diagnosed Crohn’s disease in the form of full enteral nutrition, and subsequently in remission, exacerbation, in the pre- and postoperative periods as an addition to the standard diet. Of particular interest is the CDED ModuLife program, which is based on a combination of enteral nutrition with specially selected foods aimed at reducing the activity of intestinal inflammation in Crohn’s disease. Key words: inflammatory bowel disease, Crohn’s disease, full enteral nutrition, partial enteral nutrition, enteral nutrition formulas

scholarly journals Nutritional Therapy Strategies in Pediatric Crohn’s Disease

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 212
Author(s):  
Charlotte M. Verburgt ◽  
Mohammed Ghiboub ◽  
Marc A. Benninga ◽  
Wouter J. de Jonge ◽  
Johan E. Van Limbergen
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Intestinal Inflammation ◽  
Management Strategies ◽  
Nutritional Therapy ◽  
Nutritional Deficiencies ◽  
Intestinal Immunity ◽  
Exclusive Enteral Nutrition ◽  
Therapy Strategies

The increase in incidences of pediatric Crohn’s Disease (CD) worldwide has been strongly linked with dietary shifts towards a Westernized diet, ultimately leading to altered gut microbiota and disturbance in intestinal immunity and the metabolome. Multiple clinical studies in children with CD have demonstrated the high efficacy of nutritional therapy with exclusive enteral nutrition (EEN) to induce remission with an excellent safety profile. However, EEN is poorly tolerated, limiting its compliance and clinical application. This has spiked an interest in the development of alternative and better-tolerated nutritional therapy strategies. Several nutritional therapies have now been designed not only to treat the nutritional deficiencies seen in children with active CD but also to correct dysbiosis and reduce intestinal inflammation. In this review, we report the most recent insights regarding nutritional strategies in children with active CD: EEN, partial enteral nutrition (PEN), Crohn’s disease exclusion diet (CDED), and CD treatment-with-eating diet (CD-TREAT). We describe their setup, efficacy, safety, and (dis)advantages as well as some of their potential mechanisms of action and perspectives. A better understanding of different nutritional therapeutic options and their mechanisms will yield better and safer management strategies for children with CD and may address the barriers and limitations of current strategies in children.

Use of Exclusive Enteral Nutrition Is Just as Effective as Corticosteroids in Newly Diagnosed Pediatric Crohn’s Disease

2013 ◽  
Vol 58 (12) ◽  
pp. 3584-3591 ◽  
Author(s):  
Jason Soo ◽  
Bushra A. Malik ◽  
Justine M. Turner ◽  
Rabin Persad ◽  
Eytan Wine ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Newly Diagnosed ◽  
Exclusive Enteral Nutrition

scholarly journals Newly Diagnosed Crohn’s Disease Treated with Standard Care or Enteral Nutrition: Psychological Outcomes over 6 Months

2019 ◽  
Vol 4 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Catherine L. Wall ◽  
Andrew M. McCombie ◽  
Richard B. Gearry ◽  
Andrew S. Day
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Standard Care ◽  
Psychological Outcomes ◽  
Newly Diagnosed

scholarly journals Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn’s disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kay Diederen ◽  
Jia V. Li ◽  
Gillian E. Donachie ◽  
Tim G. de Meij ◽  
Dirk R. de Waart ◽  
...  
Keyword(s):  
Amino Acids ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Bile Salts ◽  
Intestinal Inflammation ◽  
Model Systems ◽  
Intestinal Cell ◽  
Rrna Gene ◽  
Exclusive Enteral Nutrition

Abstract A nutritional intervention, exclusive enteral nutrition (EEN) can induce remission in patients with pediatric Crohn’s disease (CD). We characterized changes in the fecal microbiota and metabolome to identify the mechanism of EEN. Feces of 43 children were collected prior, during and after EEN. Microbiota and metabolites were analyzed by 16S rRNA gene amplicon sequencing and NMR. Selected metabolites were evaluated in relevant model systems. Microbiota and metabolome of patients with CD and controls were different at all time points. Amino acids, primary bile salts, trimethylamine and cadaverine were elevated in patients with CD. Microbiota and metabolome differed between responders and non-responders prior to EEN. EEN decreased microbiota diversity and reduced amino acids, trimethylamine and cadaverine towards control levels. Patients with CD had reduced microbial metabolism of bile acids that partially normalized during EEN. Trimethylamine and cadaverine inhibited intestinal cell growth. TMA and cadaverine inhibited LPS-stimulated TNF-alpha and IL-6 secretion by primary human monocytes. A diet rich in free amino acids worsened inflammation in the DSS model of intestinal inflammation. Trimethylamine, cadaverine, bile salts and amino acids could play a role in the mechanism by which EEN induces remission. Prior to EEN, microbiota and metabolome are different between responders and non-responders.

Exclusive Enteral Nutrition Modulates the Microbiota in Childhood Crohn’s Disease Independently of its Effect on Intestinal Inflammation

2017 ◽  
Vol 152 (5) ◽  
pp. S214
Author(s):  
Protima Amon ◽  
Gloria Serena ◽  
Alessio Fasano ◽  
Allan Walker ◽  
William Wade ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Intestinal Inflammation ◽  
Exclusive Enteral Nutrition

scholarly journals P-006: The effect of exclusive enteral nutrition on the microbiota of newly diagnosed pediatric Crohn’s disease patients

2014 ◽  
Vol 8 ◽  
pp. S395-S396
Author(s):  
N.O. Kaakoush ◽  
A.S. Day ◽  
S.T. Leach ◽  
D.A. Lemberg ◽  
S. Nielsen ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Newly Diagnosed ◽  
Exclusive Enteral Nutrition
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