scholarly journals Subclinical auditory dysfunction: Relationship between distortion product otoacoustic emissions and the audiogram

2020 ◽  
Author(s):  
Naomi Bramhall ◽  
Garnett McMillan ◽  
Amy Mashburn
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Distortion Product Otoacoustic Emissions ◽  
Age Group ◽  
Distortion Product ◽  
Pure Tone Audiogram ◽  
Clinically Normal ◽  
Veteran Status ◽  
Exposure History

Purpose: Both distortion product otoacoustic emissions (DPOAEs) and pure tone thresholds have been used to account for the impacts of subclinical outer hair cell (OHC) dysfunction on auditory perception and measures of auditory physiology. However, the relationship between DPOAEs and the audiogram is unclear. This study investigated this relationship by determining how well DPOAE levels can predict the pure tone audiogram among individuals with clinically normal hearing. Additionally, the impacts of age, noise exposure history, and the perception of tinnitus on the ability of DPOAE levels to predict the audiogram were evaluated.Method: Suprathreshold DPOAE levels from 1-10 kHz and pure tone thresholds from 0.25-16 kHz were measured in 366 ears from 194 young adults (19-35 years) with clinically normal audiograms (thresholds ≤ 20 dB HL from 0.25-8 kHz) and normal middle ear function. The measured DPOAE levels at all frequencies were used to predict each pure tone frequency. Participants were grouped based on age, self-reported noise exposure history/Veteran status, and self-report of tinnitus.Results: Inclusion of DPOAE levels in the pure tone threshold prediction model improved threshold predictions at all frequencies from 0.25-16 kHz compared with a model based only on sample mean pure tone thresholds, but these improvements were modest (0.4 to 2.1 dB). DPOAE levels for f2 frequencies of 4 and 5 kHz were particularly influential in predicting pure tone thresholds above 4 kHz. However, the prediction accuracy of the model varied based on participant characteristics. On average, predicted pure tone thresholds were better than measured thresholds among Veterans, individuals with tinnitus, and the oldest age group (31-35 years). In contrast, predicted thresholds tended to be poorer than measured thresholds among the youngest age group (19-25 years) and non-Veterans.Conclusions: These results indicate a complex relationship between DPOAE levels and the pure tone audiogram. Underestimation of pure tone thresholds related to Veteran status, perception of tinnitus, and older age suggests that additional factors other than OHC damage may impact pure tone thresholds among individuals within these categories. These findings suggest that DPOAE levels and pure tone thresholds may differ in terms of how well they reflect subclinical OHC dysfunction.

scholarly journals Subclinical Auditory Dysfunction: Relationship Between Distortion Product Otoacoustic Emissions and the Audiogram

2021 ◽  
pp. 1-16
Author(s):  
Naomi F. Bramhall ◽  
Garnett P. McMillan ◽  
Amy N. Mashburn
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Outer Hair Cell ◽  
Self Report ◽  
Distortion Product Otoacoustic Emissions ◽  
Sample Mean ◽  
Distortion Product ◽  
Clinically Normal ◽  
Auditory Physiology

Purpose Distortion product otoacoustic emissions (DPOAEs) and audiometric thresholds have been used to account for the impacts of subclinical outer hair cell (OHC) dysfunction on auditory perception and measures of auditory physiology. However, the relationship between DPOAEs and the audiogram is unclear. This study investigated this relationship by determining how well DPOAE levels can predict the audiogram among individuals with clinically normal hearing. Additionally, the impacts of age, noise exposure, and the perception of tinnitus on the ability of DPOAE levels to predict the audiogram were evaluated. Method Suprathreshold DPOAE levels from 1 to 10 kHz and pure-tone thresholds from 0.25 to 16 kHz were measured in 366 ears from 194 young adults (19–35 years old) with clinically normal audiograms and middle ear function. The measured DPOAE levels at all frequencies were used to predict pure-tone thresholds at each frequency. Participants were grouped by age, self-reported noise exposure/Veteran status, and self-report of tinnitus. Results Including DPOAE levels in the pure-tone threshold prediction model improved threshold predictions at all frequencies from 0.25 to 16 kHz compared with a model based only on sample mean pure-tone thresholds, but these improvements were modest. DPOAE levels for f 2 frequencies of 4 and 5 kHz were particularly influential in predicting pure-tone thresholds above 4 kHz. However, prediction accuracy varied based on participant characteristics. On average, predicted pure-tone thresholds were better than measured thresholds among Veterans, individuals with tinnitus, and the oldest age group. Conclusions These results indicate a complex relationship between DPOAE levels and the audiogram. Underestimation of pure-tone thresholds for some groups suggests that additional factors other than OHC damage may impact thresholds among individuals within these categories. These findings suggest that DPOAE levels and pure-tone thresholds may differ in terms of how well they reflect subclinical OHC dysfunction. Supplemental Material https://doi.org/10.23641/asha.13564745

Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure

2015 ◽  
Vol 129 (12) ◽  
pp. 1174-1181 ◽  
Author(s):  
N Wooles ◽  
M Mulheran ◽  
P Bray ◽  
M Brewster ◽  
A R Banerjee
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

AbstractObjective:To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit.Methods:A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obtained sequentially during mandatory screening of brickyard workers (n = 16). Individual pure tone audiometry thresholds were compared with distortion product otoacoustic emission amplitudes, and a correlation of these measurements was conducted.Results:Pure tone audiometry threshold elevation was identified in 13 out of 16 workers. When distortion product otoacoustic emission amplitudes were compared with pure tone audiometry thresholds at matched frequencies, no evidence of a robust relationship was apparent. Seven out of 16 workers had substantial distortion product otoacoustic emissions with elevated pure tone audiometry thresholds.Conclusion:No clinically relevant predictive relationship between distortion product otoacoustic emission amplitude and pure tone audiometry threshold was apparent. These results do not support the replacement of pure tone audiometry with distortion product otoacoustic emissions in screening. Distortion product otoacoustic emissions at frequencies associated with elevated pure tone audiometry thresholds are evidence of intact outer hair cell function, suggesting that sites distinct from these contribute to auditory deficit following ototrauma.

Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions

2004 ◽  
Vol 194 (1-2) ◽  
pp. 87-96 ◽  
Author(s):  
Ana E Vázquez ◽  
Ana M Jimenez ◽  
Glen K Martin ◽  
Anne E Luebke ◽  
Brenda L Lonsbury-Martin
Keyword(s):  
Otoacoustic Emissions ◽  
Noise Exposure ◽  
Distortion Product Otoacoustic Emissions ◽  
Cochlear Function ◽  
Distortion Product

scholarly journals Hubungan ototoksisitas dan kemoterapi neoadjuvan pada karsinoma nasofaring berdasarkan ASHA, CTCAE, dan DPOAE

2018 ◽  
Vol 47 (2) ◽  
pp. 102
Author(s):  
Meyrna Heryaning Putri ◽  
Pudji Rahaju ◽  
Dyah Indrasworo
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Early Detection ◽  
Adverse Events ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Distortion Product Otoacoustic Emissions ◽  
Hearing Level ◽  
Type Iii ◽  
Distortion Product ◽  
Significant Difference

Latar belakang: Kemoterapi neoadjuvan adalah induksi kemoterapi sebelum radioterapi dengan regimen cisplatin dan 5-Fluorouracil. Kemoterapi cisplatin bersifat ototoksik pada pendengaran sensorineural bilateral progresif dan bersifat irreversible. Kriteria dari American Speech-Language Hearing Association (ASHA) dan Common Terminology Criteria for Adverse Events (CTCAE) merupakan kriteria untuk mengidentifikasi ototoksisitas dengan menggunakan audiometri, selain pemeriksaan Distortion Product Otoacoustic Emissions (DPOAE). Tujuan: Mengidentifikasi hubungan ototoksisitas dengan kemoterapi neoadjuvan pada penderita karsinoma nasofaring (KNF) WHO tipe III menggunakan ASHA, CTCAE, serta DPOAE. Metode: Studi ini adalah penelitian observasional dengan desain cohort. Kriteria inklusi penelitian yaitu penderita baru KNF WHO tipe III, yang mendapatkan kemoterapi regimen standar dan berusia <60 tahun. Kriteria pemeriksaan DPOAE adalah penderita dengan ambang dengar ≤40 dB. Percontoh dilakukan pemeriksaan timpanometri, audiometri, dan DPOAE. Hasil: Terdapat 9 sampel percontoh penelitian. Uji repeated-ANOVA menunjukkan tidak ditemukan perbedaan bermakna pada tiga hasil pengukuran audiometri antara pascakemoterapi pertama, kedua, dan ketiga (p>0,05). Deteksi awal ototoksisitas menggunakan kriteria ASHA menunjukkan sensitivitas sebesar 67% dan dan CTCAE 44%, dibandingkan baku emas menggunakan DPOAE. Kesimpulan: Ototoksisitas cisplatin ditemukan sejak kemoterapi pertama dengan menggunakan pemeriksaan DPOAE walaupun tidak bermakna secara statistik. Kemampuan DPOAE untuk mendeteksi awal ototoksisitas lebih baik dibandingkan kriteria ASHA dan CTCAE yang menggunakan audiometri nada murni.Kata kunci: Karsinoma nasofaring, ototoksisitas sisplatin, DPOAE, CTCAE, ASHA ABSTRACT Introduction: Neoadjuvant chemotherapy is induction chemotherapy before radiotherapy with cisplatin and 5-Fluorouracyl regiment. Chemotherapy cisplatin is ototoxic, leads to frequently progresive and irreversible bilateral sensorineural hearing loss. American Speech-Language Hearing Association (ASHA) and Common Terminology Criteria for Adverse Events (CTCAE) are the criteria to determine ototoxicity with audiometry, beside Distortion Product Otoacoustic Emissions (DPOAE). Purpose: To identify the relationship between ototoxicity with neoadjuvant chemotherapy in patients NPC WHO type III using ASHA, CTCAE, and DPOAE. Method: This observational study approach with cohort design. Inclusion criteria: new patients NPC WHO type III who consented to undergo standard regiment chemotherapy, and age <60 year-old. For DPOAE examination: hearing level ≤40 dB. Exclucion criteria: NPC WHO type III patients who underwent chemotherapy with unconventional standard regiment. Examinations for hearing function conducted with tympanometry, pure tone audiometry, and Distortion Product Otoacoustic Emissions (DPOAE). Result: There were 9 sample in this study. The result of Repeated-ANOVA test showed no significant difference in three audiometry measurements among three series of chemotherapies. Early detection of ototoxicity using ASHA and CTCAE criterias showed sensitivity of 67% and 44% (compared with DPOAE as a gold standard). Conclusion: Cisplatin ototoxicity had occured since the first chemotherapy and detected with DPOAE, but statistically was not significantly related. Early detection of cisplatin ototoxicity with DPOAE was much better than with criteria American Speech-Language Hearing Association (ASHA) and Common Terminology Criteria for Adverse Events (CTCAE), which used pure tone audiometry.Keywords: Nasopharyngeal carcinoma, cisplatin ototoxicity, DPOAE, CTCAE, ASHA

A longitudinal study of changes in distortion-product otoacoustic emissions and pure-tone thresholds in an industrial setting

2013 ◽  
Vol 271 (10) ◽  
pp. 2649-2660
Author(s):  
Antonis Moukos ◽  
Dimitrios G. Balatsouras ◽  
Thomas Nikolopoulos ◽  
Pavlos Maragoudakis ◽  
Evangelos I. Yiotakis ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product ◽  
Industrial Setting
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