Evaluating the Internal Consistency of Subtraction-Based and Residualized Difference Scores: Considerations for Studies of Event-Related Potentials
In studies of event-related brain potentials (ERPs), difference scores between conditions in a task are frequently used to isolate neural activity for use as a dependent or independent variable. Adequate score reliability is a prerequisite for studies examining relationships between ERPs and external correlates, but there is a widely held view that difference scores are inherently unreliable and unsuitable for studies of individual differences. This view fails to consider the nuances of difference score reliability that are relevant to ERP research. In the present study, we provide formulas from classical test theory and generalizability theory for estimating the internal consistency of subtraction-based and residualized difference scores. These formulas are then applied to error-related negativity (ERN) and reward positivity (RewP) difference scores from the same sample of 117 participants. Analyses demonstrate that ERN difference scores can be reliable, which supports their use in studies of individual differences. However, RewP difference scores yielded poor reliability due to the high correlation between the constituent reward and non-reward ERPs. Findings emphasize that difference score reliability largely depends on the internal consistency of constituent scores and the correlation between those scores. Furthermore, generalizability theory estimates yielded higher internal consistency estimates for subtraction-based difference scores than classical test theory estimates did. Despite some beliefs that difference scores are inherently unreliable, ERP difference scores can show adequate reliability and be useful for isolating neural activity in studies of individual differences.