A study on neurodevelopmental outcome and its associated risk factors in very low birth weight babies in a tertiary care teaching hospital in Kolkata

Background: Very low birth weight babies are very fragile in nature and usually undergone through stormy neonatal period, which affects significantly their neurodevelopmental outcome in long term basis.Aims and Objectives: 1. Assessment of neurodevelopmental outcome in very low birth weight (VLBW) babies at 12 month corrected gestational age. 2. Study of risk factors associated with such outcome.Materials and Methods: VLBW babies without any major congenital anomaly were included in this study. They were followed up in high risk clinic upto 12 month corrected gestational age. In follow up visits, assessment of tone was done by Amiel Tiesonmethod and 180 degree flip test. Developmental screening was done by Denver Developmental Screening Test (DDST II).Data obtained from this study were entered in Microsoft Excel and subsequently analysed with the help of Epi Info (TM) 3.5.3 software.Results: 24.4% among the study population showed neurodevelopmental abnormalities. Of them, 22.2% VLBW infants had muscle tone abnormality; 15.6% were suspect in gross motor development, 8.9% were suspect in fine motor, 11.1% were suspect in personal – social and 8.9% were suspect in language development, which were statistically significant. On assessment of risk factors, it was found that low birth weight, prematurity, non-use of antenatal corticosteroid, hypoglycaemia, intraventricular haemorrhage, sepsis, jaundice, mechanical ventilation, intra uterine growth retardation were significantly associated with various strata of neurodevelopmental outcome.Conclusion: VLBW babies are very prone to develop neurodevelopmental complications. Taking proper care regarding above said risk factors can reduce such complications. Also these babies should follow up properly to detect complication/s at earliest, and take “early intervention’’ steps.Asian Journal of Medical Sciences Vol.7(5) 2016 61-69

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Influence of the level of maternal education on the long-term neurodevelopmental outcome of Saudi infants with birth weight of 1000-1500 grams at the age of 21-24 months

10.33118/oaj.preg.2019.01.005 ◽

2019 ◽

Vol 1 (1) ◽

Author(s):

Badr Hasan Sobaih

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Maternal Education ◽

Very Low Birth Weight ◽

Neurodevelopmental Outcome ◽

University Hospital ◽

Vlbw Infants

Background: Advancements in perinatal-neonatal care in the last decades has led to improved survival rates of very-low birth weight (VLBW) infants. An association between the level of maternal education and neurodevelopmental outcome has been demonstrated in many European studies. This study evaluates the influence of maternal education level and socio-demographic status on the long-term development of Saudi VLBW infants with birth weight of 1000-1500 grams at a corrected gestational age of 21-24 months. Method: This retrospective cohort study examined prospectively collected data from the period of 2005 to 2016 from the Neonatal Follow-up Program (NFP) at King Khalid University Hospital in Riyadh, Saudi Arabia. Results: A total of 122 VLBW infants with a mean gestational age of 29.57 weeks and mean birth weight 1265 grams were enrolled. There was no statistically significant association between the level of maternal education and neurodevelopmental screening outcome at the age of 21-24 months according to the Bayley Infant Neurodevelopmental Screener (BINS) (p=0.149). Bronchopulmonary dysplasia (BPD) was highly associated with cerebral palsy (p=0.001) and an abnormal BINS score (p=0.010). Conclusion: There was no significant influence of the level of maternal education on the neurodevelopmental screening outcome of VLBW infants at the corrected age of 21-24 months. BPD was the strongest predictor of adverse neurodevelopmental outcome. Keywords: Bayley Infant Neurodevelopmental Screener (BINS), Neurodevelopmental Outcome, Maternal educational level, Neonatal follow-up program (NFP), Very Low Birth Weight (VLBW) infant.

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Intraventricular hemorrhage in very low birth weight infants: associated risk factors and outcome in the neonatal period

Revista do Hospital das Clínicas ◽

10.1590/s0041-87811999000500004 ◽

1999 ◽

Vol 54 (5) ◽

pp. 151-154 ◽

Cited By ~ 15

Author(s):

Monique Catache Mancini ◽

Naila Elias Barbosa ◽

Débora Banwart ◽

Sandra Silveira ◽

José Luiz Guerpelli ◽

...

Keyword(s):

Risk Factors ◽

Mechanical Ventilation ◽

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Intraventricular Hemorrhage ◽

Very Low Birth Weight ◽

Periventricular Leukomalacia ◽

Associated Risk Factors ◽

Length Of Hospitalization

Intraventricular hemorrhage (IVH) is a severe complication in very low birth weight (VLBW) newborns (NB). With the purpose of studying the incidence of IVH, the associated risk factors, and the outcomes for these neonates, we studied all the VLBW infants born in our neonatal unit. Birth weight, gestational age, presence of perinatal asphyxia, mechanical ventilation, length of hospitalization, apnea crisis, hydrocephalus, and periventricular leukomalacia were analyzed. The diagnosis of IVH was based on ultrasound scan studies (Papile's classification) performed until the tenth day of life and repeated weekly in the presence of abnormalities. Sixty-seven/101 neonates were studied. The mortality rate was 30.6% (31/101) and the incidence of IVH was 29.8% (20/67) : 70% grade I, 20% grade III and 10% grade IV. The incidence of IVH in NB <1,000 g was 53.8% (p = 0.035) and for gestational age <30 weeks was 47.3% (p = 0.04), both considered risk factors for IVH. The length of hospitalization (p = 0.00015) and mechanical ventilation (p = 0.038) were longer in IHV NB. The IVH NB had a relative risk of 2.3 of developing apnea (p = 0.02), 3.7 of hydrocephalus (p = 0.0007), and 7.7 of periventricular leukomalacia (p < 0.00001). The authors emphasize the importance of knowing the risk factors related to IVH so as to introduce prevention schemes to reduce IVH and to improve outcomes of affected newborns.

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Neurodevelopmental outcome of very low birth weight babies admitted to a Malaysian nursery

Journal of Paediatrics and Child Health ◽

10.1046/j.1440-1754.1999.t01-1-00340.x ◽

1999 ◽

Vol 35 (2) ◽

pp. 175-180 ◽

Cited By ~ 10

Author(s):

JJ Ho ◽

HSS Amar ◽

AJ Mohan ◽

TH Hon

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Very Low Birth Weight ◽

Neurodevelopmental Outcome ◽

Low Birth Weight Babies

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Neurodevelopmental Outcome of Appropriate and Small for Gestational Age Very Low Birth Weight Infants

Journal of Child Neurology ◽

10.1177/0883073808331087 ◽

2009 ◽

Vol 24 (7) ◽

pp. 788-794 ◽

Cited By ~ 21

Author(s):

Renato S. Procianoy ◽

Maike S. Koch ◽

Rita C. Silveira

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Small For Gestational Age ◽

Very Low Birth Weight ◽

Neurodevelopmental Outcome ◽

Low Birth Weight Infants

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Growth and Neurodevelopmental Outcome of Very Low Birth Weight Babies at 1 Year of Age

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v5i6.172 ◽

2017 ◽

Vol 05 (06) ◽

pp. 23836-23840

Author(s):

Dr Radhika. S ◽

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Very Low Birth Weight ◽

Neurodevelopmental Outcome ◽

Low Birth Weight Babies

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Retinopathy of prematurity in preterm babies in a local medical college and hospital

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20201343 ◽

2020 ◽

Vol 8 (4) ◽

pp. 1463

Author(s):

Shantisena Mishra ◽

Anjali Saji ◽

Saiprasanna Behera ◽

Sridhar Mohanty

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Mode Of Delivery ◽

Multiple Gestation ◽

Maternal Risk ◽

Preterm Babies

Background: Retinopathy of prematurity is a multifactorial vasoproliferative retinal disease that increases in incidence with decreasing gestational age and is one of the leading causes of preventable childhood blindness in India. Advances in neonatology have led to dramatic increase in survival of preterm neonates and in turn, to the risk of developing ROP. Since most of the risk factors associated with ROP mentioned above arise in the neonatal intensive care unit (NICU) itself and most of them are avoidable, cautious monitoring of the risk factors, early screening, follow up and surgical intervention have been shown to reduce the incidence and improve the outcome of ROP.Methods: This was a prospective observational study conducted for a period of 2 years. A total of 151 infants admitted in NICU /SNCU who satisfied the inclusion criteria were enrolled in this study. Initial and follow up screening was conducted in three phases the results were documented in proforma after ethical clearance.Results: Comparison of risk factors between eyes with and without ROP was done using Chi-square test. A p-value of<0.05 was considered to be statistically significant. Incidence of ROP in centre is found to be 33.8%. Among maternal risk factors, multiple gestation and PROM/PPROM is found to be significant in the development of ROP from this study. However, mode of delivery and gestational hypertension, were found to be not significant in ROP. Among neonatal risk factors, low birth weight, lower gestational age, prolonged oxygen exposure, blood transfusion, mechanical ventilation, sepsis, phototherapy was found to be significant in this study.Conclusions: ROP, being an emerging cause for potentially blinding visual disability, needs to be diagnosed early. Due to the advancements in neonatology and better survival of preterm babies, timely screening, regular follow up, early detection and intervention is mandatory. A multidisciplinary approach is required in diagnosis and treatment of the disease. Proper counselling and motivation for parents of preterm and low birth weight babies for regular follow up is also essential.

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Neuroprem 2: An Italian Study of Neurodevelopmental Outcomes of Very Low Birth Weight Infants

Frontiers in Pediatrics ◽

10.3389/fped.2021.697100 ◽

2021 ◽

Vol 9 ◽

Author(s):

Licia Lugli ◽

Luca Bedetti ◽

Isotta Guidotti ◽

Marisa Pugliese ◽

Odoardo Picciolini ◽

...

Keyword(s):

Risk Factors ◽

Cerebral Palsy ◽

Birth Weight ◽

Gestational Age ◽

Functional Disability ◽

Very Low Birth Weight ◽

Neurodevelopmental Outcomes ◽

Vlbw Infants ◽

Neurodevelopmental Disabilities

Background: Despite the increased survival of preterm newborns worldwide, the risk of neurodevelopmental disabilities remains high. Analyzing the outcomes of the preterm population can identify risk factors and enable specific early interventions.Aims: Neuroprem is a prospective cohort study of very low birth weight (VLBW) infants that aims to evaluate the neurodevelopmental outcomes and risk factors for severe functional disability at 2 years of corrected age.Methods: Nine Italian neonatal intensive care units participated in the network. The Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and a neuro-functional evaluation (according to the International Classification of Disability and Health and Neuro-Functional Assessment, or NFA ICF-CY) were administered to VLBW infants at 24 months of corrected age. The primary outcome measure was severe functional disability, defined as cerebral palsy, bilateral blindness, deafness, an NFA ICF-CY of >2, a BSDI III cognitive composite score of <2 SD, or a GMDS-R global quotient score of <2 SD. Perinatal risk factors for severe functional disability were assessed through multivariate logistic regression analysis.Results: Among 502 VLBW survivors who completed the 24-month follow-up, 48 (9.6%) presented severe functional disability, of whom 27 had cerebral palsy (5.4%). Rates of severe functional disability and cerebral palsy were higher in neonates with a lower gestational age (p < 0.001). Overall, 147 infants (29.3%) were referred to neuromotor intervention. In the multivariate regression model, gestational age at birth OR 0.79; 95% CI 0.67–0.90; p = 0.001) and periventricular-intraventricular hemorrhage (OR 2.51; 95% CI 1.19–5.26; p = 0.015) were significantly associated with severe functional disability.Conclusion: Neuroprem 2 provides updated information on the neurodevelopmental outcomes of VLBW infants in a large Italian cohort. The overall rate of neurodevelopmental disabilities was quite lower than reported in the previous literature. These data indicate the need for structured follow-up programs from a national neonatal network perspective.

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