scholarly journals Correlation between T and N Stages of Head and Neck Squamous Cell Carcinoma

2015 ◽  
Vol 10 (4) ◽  
pp. 26-31
Author(s):  
Krishna Koirala ◽  
Bimal Sinha ◽  
Dharma Kanta Baskota
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Neck Squamous Cell Carcinoma ◽  
Neck Node ◽  
Head And Neck Region ◽  
N Stage ◽  
N Status

Background and Objective: Squamous cell carcinoma of the head and neck region is a common pathological entity. Advanced primary lesion (T) and neck node metastasis (N) both are bad prognostic features for the carcinoma. Purpose of this prospective cross sectional study is to see if T stage of primary Head and Neck squamous cell carcinoma correlates with N stage of Neck node metastasis.Materials and Methods: Patients of all ages and both sex with biopsy proven squamous cell carcinoma of Head and Neck region were included in the study. After detailed history taking and clinical examination to identify the clinical T and N status of the disease, biopsy was taken from the primary site under local or general anesthesia. Fine Needle Aspiration Cytology (FNAC) of the palpable neck node (s) was performed. Correlation of T stage of the primary tumor was seen with that of N stage of the neck by applying the statistical tests.Results: There was significant correlation of the T status of the primary head and neck carcinoma with N status of the secondary neck.Conclusion: The T status of primary head and neck squamous cell carcinoma correlates with the N status of Neck in general. By knowing the T status of the primary tumor, we can predict the nodal status in most of the cases of head and neck carcinomas which can be used in planning the treatment modalities also.JCMS Nepal 2014; 10(4):26-31

Clinical values for abnormal 18F-FDG uptake in the head and neck region of patients with head and neck squamous cell carcinoma

2014 ◽  
Vol 83 (8) ◽  
pp. 1455-1460 ◽  
Author(s):  
Hwan Seo Lee ◽  
Jae Seung Kim ◽  
Jong-Lyel Roh ◽  
Seung-Ho Choi ◽  
Soon Yuhl Nam ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Neck Squamous Cell Carcinoma ◽  
Head And Neck Region ◽  
Fdg Uptake ◽  
18F Fdg

Mucosal Adenoid Squamous Cell Carcinoma of the Head and Neck

1996 ◽  
Vol 105 (5) ◽  
pp. 409-413 ◽  
Author(s):  
Alfio Ferlito ◽  
Kenneth O. Devaney ◽  
Christopher M. Milroy ◽  
Alessandra Rinaldo ◽  
Antonino Carbone
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adenosquamous Carcinoma ◽  
Neck Region ◽  
Metastatic Adenocarcinoma ◽  
Head And Neck Region ◽  
Adenoid Cystic ◽  
Basaloid Squamous

Adenoid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma. The lesion is histologically distinctive and it is usually localized on the skin of the head and neck region; it only rarely involves the mucosal sites. The differential diagnoses include adenosquamous carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, basaloid squamous cell carcinoma, and metastatic adenocarcinoma. Surgery is the treatment of choice. The biologic behavior of this neoplasm is more aggressive when it involves mucosal areas, and the prognosis seems worse than that of conventional squamous cell carcinoma.

scholarly journals Quantification analysis of tissue eosinophilia in squamous cell carcinoma of the head and neck region

2018 ◽  
Vol 7 (1) ◽  
pp. 165 ◽  
Author(s):  
M Sabzijate ◽  
AH Khatibi ◽  
T Ghiasian ◽  
S Rahrotaban ◽  
E Rastegar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Head And Neck Region ◽  
Tissue Eosinophilia ◽  
Quantification Analysis

Targeting the PI3K Pathway in Head and Neck Squamous Cell Carcinoma

2015 ◽  
pp. 123-128 ◽  
Author(s):  
Pedro Henrique Isaacsson Velho ◽  
Gilberto Castro ◽  
Christine H. Chung
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Anticancer Agents ◽  
Neck Region ◽  
Hpv Infection ◽  
Pi3k Pathway ◽  
Neck Squamous Cell Carcinoma ◽  
Preclinical Data

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease arising from the mucosal epithelia in the head and neck region. The most common risk factors are tobacco use, alcohol consumption, and HPV infection, particularly in the oropharynx. The HPV-positive HNSCC is biologically and clinically distinct from the HPV-negative HNSCC; however, deregulations within the phosphatidylinositol 3-kinase (PI3K) pathway are frequent in both HPV-positive and HPV-negative HNSCC as it is the most frequently altered oncogenic pathway with a gain-of-function in HNSCC. This article reviews the basic biology and clinical data from the trials involving anticancer agents targeting the PI3K pathway in HNSCC. It also discusses the difficulties of translating the preclinical data to tangible clinical efficacy of these agents in patients with HNSCC even when there is significant preclinical data suggesting the PI3K pathway is a promising therapeutic target in HNSCC. We conclude that additional studies to determine appropriate patient selection for the activation of PI3K pathway and to develop targeted agents either as a monotherapy or combination therapy with favorable toxicity profiles are required before a broader clinical application.

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