Clinical values for abnormal 18F-FDG uptake in the head and neck region of patients with head and neck squamous cell carcinoma

Background and Objective: Squamous cell carcinoma of the head and neck region is a common pathological entity. Advanced primary lesion (T) and neck node metastasis (N) both are bad prognostic features for the carcinoma. Purpose of this prospective cross sectional study is to see if T stage of primary Head and Neck squamous cell carcinoma correlates with N stage of Neck node metastasis.Materials and Methods: Patients of all ages and both sex with biopsy proven squamous cell carcinoma of Head and Neck region were included in the study. After detailed history taking and clinical examination to identify the clinical T and N status of the disease, biopsy was taken from the primary site under local or general anesthesia. Fine Needle Aspiration Cytology (FNAC) of the palpable neck node (s) was performed. Correlation of T stage of the primary tumor was seen with that of N stage of the neck by applying the statistical tests.Results: There was significant correlation of the T status of the primary head and neck carcinoma with N status of the secondary neck.Conclusion: The T status of primary head and neck squamous cell carcinoma correlates with the N status of Neck in general. By knowing the T status of the primary tumor, we can predict the nodal status in most of the cases of head and neck carcinomas which can be used in planning the treatment modalities also.JCMS Nepal 2014; 10(4):26-31

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18F-FDG PET cannot predict expression of clinically relevant histopathological biomarkers in head and neck squamous cell carcinoma: a meta-analysis

Acta Radiologica ◽

10.1177/0284185121988973 ◽

2021 ◽

pp. 028418512198897

Author(s):

Alexey Surov ◽

Maciej Pech ◽

Alexander Eckert ◽

Christoph Arens ◽

Oliver Grosser ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Growth Factor ◽

Tumor Cell ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Fdg Pet ◽

Neck Squamous Cell Carcinoma ◽

Histopathological Features ◽

18F Fdg

Background Head and neck squamous cell carcinoma (HNSCC) is a common cancer. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) is a widely used imaging modality in HNSCC. Purpose To provide evident data about associations between 18F-FDG PET and histopathology in HNSCC. Material and Methods The MEDLINE database was screened for associations between maximum standard uptake values (SUVmax) derived from 18F-FDG PET and histopathological features in HNSCC up to May 2020. Only papers containing correlation coefficients between SUVmax and histopathology were acquired. Overall, 23 publications were collected. Results The following correlations were calculated: KI 67: 12 studies (345 patients), pooled correlation coefficient (PCC): 0.23 (95% confidence interval [CI] 0.06–0.40); hypoxia-inducible factor-1α: eight studies (240 patients), PCC: 0.24 (95% CI 0.06–0.42); microvessel density: three studies (64 patients), PCC: 0.33 (95% CI 0.02–0.65); vascular endothelial growth factor: two studies (59 cases), PCC: 0.27 (95% CI 0.02–0.51); tumor suppressor protein p53: four studies (159 patients), PCC: 0.05 (95% CI –0.41 to 0.51); epidermal growth factor receptor: two studies (124 patients), PCC: 0.21 (95% CI 0.05–0.37); tumor cell count: three studies (67 patients), PCC: 0.18 (95% CI –0.06 to 0.42); tumor cell apoptosis: two studies (40 patients), PCC: 0.07 (95% CI = –0.85 to 0.99); B-cell lymphoma-2 protein: two studies (118 patients); PCC: 0.04 (95% CI –0.65 to 0.74); glucose-transporter 1: 10 studies (317 patients), PCC: 0.20 (95% CI 0.10–0.30). Conclusion SUVmax derived from 18F-FDG PET cannot reflect relevant histopathological features in HNSCC.

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Mucosal Adenoid Squamous Cell Carcinoma of the Head and Neck

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949610500515 ◽

1996 ◽

Vol 105 (5) ◽

pp. 409-413 ◽

Cited By ~ 25

Author(s):

Alfio Ferlito ◽

Kenneth O. Devaney ◽

Christopher M. Milroy ◽

Alessandra Rinaldo ◽

Antonino Carbone

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Adenosquamous Carcinoma ◽

Neck Region ◽

Metastatic Adenocarcinoma ◽

Head And Neck Region ◽

Adenoid Cystic ◽

Basaloid Squamous

Adenoid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma. The lesion is histologically distinctive and it is usually localized on the skin of the head and neck region; it only rarely involves the mucosal sites. The differential diagnoses include adenosquamous carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, basaloid squamous cell carcinoma, and metastatic adenocarcinoma. Surgery is the treatment of choice. The biologic behavior of this neoplasm is more aggressive when it involves mucosal areas, and the prognosis seems worse than that of conventional squamous cell carcinoma.

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