scholarly journals Tumour and tumour-like conditions of peripheral nerve origin: Ten years’ experience

1970 ◽  
Vol 8 (1) ◽  
pp. 97-101
Author(s):  
A Ghosh ◽  
OP Talwar ◽  
SV Pradhan
Keyword(s):  
Medical Journal ◽  
Peripheral Nerve ◽  
Benign Tumor ◽  
Age Distribution ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Site Distribution ◽  
Cosmetic Reason ◽  
Nerve Sheath ◽  
Age Range

Background: There are four major lesions which may arise in the peripheral nerve, namely neuroma, schwannoma, neurofibroma and malignant peripheral nerve sheath tumor. Objective: In the present study we look into the spectrum of peripheral neural tumors including their age distribution site distribution and histopathology. Materials and methods: This is retrospective study conducted in the Dept of Pathology, Manipal Teaching Hospital, Pokhara. All histopathologically diagnosed cases of primary lesions of peripheral nerve during the period Jan 2000 to Nov 2009 were reviewed and the data were analysed. Result: A total of 114 cases of peripheral neural lesions were reported in the same period. Total number of nonmalignant cases was 106 (93%) while malignant cases were 8 (7%). Among the nonmalignant cases neurofiboma was the commonest (51 cases, 45% of all) closely followed by schwannoma (39 cases, 34% of all). Among the neurofibroma cases only 2 cases had multiple neurofibromatosis while others were solitary. Among the schwannoma cases 4 were diagnosed as ancient schwannoma with presence of bizarre cells with hyperchromatic nuclei. The commonest site involved for both schwannoma and neurofibroma was scalp-face-neck followed by back. The age range for schwannoma was 16 to 75 years whereas the same for the neurofibroma cases was 2 to 82 years. MPNST cases were seen in the age range of 40 to 72 with 3 cases in upper extremity, 3 in lower extremity and 1 each in lip and cheek. 1 case was diagnosed as cellular neurofibroma with atypia in tongue and was confirmed by S100. Conclusion The majority of the tumor are benign and the commonest benign tumor was neurofibroma of sporadic type, closely followed by schwannoma. In our study the commonest site was scalp-face-neck unlike other studies. This may be due to more compliance of the patients due to cosmetic reason. ey words : Malignant peripheral nerve sheath tumor; Neurofibroma; Peripheral nerve; Schwannoma DOI: 10.3126/kumj.v8i1.3231 Kathmandu University Medical Journal (2010), Vol. 8, No. 1, Issue 29, 97-101

Malignant Peripheral Nerve Sheath Tumor Arising from a Solitary Neurofibroma in a Patient without Neurofibromatosis Type 1

2016 ◽  
Vol 78 (5) ◽  
pp. 516-521
Author(s):  
Fumihisa SAWADA ◽  
Eiichi MAKINO ◽  
Takenobu YAMAMOTO ◽  
Ryo TANAKA ◽  
Yutaka FUJIWARA ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Solitary Neurofibroma

scholarly journals RARE-20. MALIGNANT PERIPHERAL NERVE SHEATH TUMOR OF A CRANIAL NERVE IN AN INFANT WITH NEUROCUTANEOUS MELANOSIS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii446-iii446
Author(s):  
Lacey Carter ◽  
Naina Gross ◽  
Rene McNall-Knapp ◽  
,and Jo Elle Peterson
Keyword(s):  
Peripheral Nerve ◽  
Cranial Nerve ◽  
Leptomeningeal Disease ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Neurocutaneous Melanosis ◽  
Spindle Cell Neoplasm ◽  
Lower Back ◽  
Nerve Sheath ◽  
S 100

Abstract At one month of age, a female presented with a giant congenital nevus along lower back and thighs and hydrocephalus. A ventriculoperitoneal shunt was placed. An MRI was done at six months, initially reported as normal. At eleven months of age, five months after original MRI, patient presented with dysconjugate gaze and lethargy. MRI showed new 3.8 x 3.7 x 3.4 cm right cerebellopontine angle mass extending into Meckel’s cave and foramen ovale along with leptomeningeal disease extending from the mass along the entire length of the spinal cord. Retrospective review of prior MRI revealed subtle leptomeningeal enhancement concerning for neurocutaneous melanosis (NCM). Given the leptomeningeal disease, family elected for open biopsy and debulking of lesion instead of aggressive resection. Histologically, the mass showed hypercellular spindle cell neoplasm with mitotic activity and necrosis mixed with remnants of normal cranial nerve. GFAP was negative, excluding a glioma. HMB-45, MITF, panmelanoma, and Melan-A were negative, excluding melanoma. A negative myogenin stain ruled out ectomesenchymoma. S-100 protein and SOX-10 positivity with variable loss of staining for trimethylation of histone H3 K27 were indicative of malignant peripheral nerve sheath tumor (MPNST). Given the course of the mass, trigeminal nerve MPNST was presumed. Given the poor prognosis of intracranial MPNST and NCM, family elected to forgo treatment and was discharged with hospice. She died 25 days after surgery. Cranial nerve MPNST is rare. MPNST in patients with NCM has not previously been reported to our knowledge.

Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation

2021 ◽  
Author(s):  
Miriam Magallón-Lorenz ◽  
Juana Fernández-Rodríguez ◽  
Ernest Terribas ◽  
Edgar Creus-Batchiller ◽  
Cleofe Romagosa ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Chromosomal Translocations ◽  
Nerve Sheath Tumor ◽  
Tumor Initiation ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Single Path

Gastric Malignant Peripheral Nerve Sheath Tumor

2015 ◽  
Vol 23 (6) ◽  
pp. 505-508 ◽  
Author(s):  
Eun Young Kim ◽  
Sung Hak Lee ◽  
Han Mo Yoo ◽  
Kyo Young Song ◽  
Cho Hyun Park
Keyword(s):  
Peripheral Nerve ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath

Intermediate Follow-up and Management of Previously Reported Malignant Peripheral Nerve Sheath Tumor of the Penis

Urology ◽  
2020 ◽  
Vol 135 ◽  
pp. 133-135 ◽  
Author(s):  
Hannah Agard ◽  
Neel Parekh ◽  
Curtis Clark ◽  
Eric Massanyi ◽  
Ananth Murthy ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath

scholarly journals Malignant Peripheral Nerve Sheath Tumor in the Nasal Cavity of a Neonate: A Case Report

2021 ◽  
pp. 014556132110141
Author(s):  
Xiufang Chi ◽  
Yue Wang ◽  
Haoming Yang ◽  
Cheng Xing ◽  
Jiamin Gan ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Peripheral Nerve ◽  
Nasal Cavity ◽  
Nerve Fibers ◽  
Nerve Sheath Tumor ◽  
Rare Tumor ◽  
Nasal Mass ◽  
Peripheral Nerve Sheath Tumor ◽  
Related Literature ◽  
Nerve Sheath

Malignant peripheral nerve sheath tumor (MPNST) is a rare tumor that can develop on the lining of nerves and within the network of nerve fibers in different organs, and it is commonly found in the head and neck, limbs, and trunk. These tumors can occur in patients of any age. They most commonly occur in adults aged 20 to 50 years; however, fewer cases of this tumor in children have been reported. To date, no neonatal case of MPNST in the nasal cavity has been reported. Here, we report the case of a 4-day-old female newborn who presented with a nasal mass that re-enlarged after surgery and was diagnosed as MPNST of the nasal cavity on the basis of pathological results. This is the first report of MPNST in the nasal cavity of a neonate. Differential diagnosis and treatment of nasal masses have been proposed in the related literature.

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