scholarly journals Outcome of Pregnancy Complicated by Threatened Abortion

2012 ◽  
Vol 9 (1) ◽  
pp. 41-44 ◽  
Author(s):  
A Dongol ◽  
S Mool ◽  
P Tiwari
Keyword(s):  
Folic Acid ◽  
Spontaneous Abortion ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Bed Rest ◽  
Folic Acid Supplementation ◽  
Intrauterine Death ◽  
Acid Supplementation ◽  
Intrauterine Growth ◽  
Threatened Abortion

Background Threatened abortion is the most common complication in the first half of pregnancy. Most of these pregnancies continue to term with or without treatment. Spontaneous abortion occurs in less than 30% of these women. Threatened abortion had been shown to be associated with increased incidence of antepartum haemorrhage, preterm labour and intra uterine growth retardation. Objective This study was to asses the outcome of threatened abortion following treatment. Methods This prospective study was carried out in Dhulikhel Hospital - Kathmandu University Hospital from January 2009 till May 2010. Total 70 cases of threatened abortion were selected, managed with complete bed rest till 48 hrs of cessation of bleeding, folic acid supplementation, uterine sedative, and hormonal treatment till 28 weeks of gestation. Ultrasonogram was performed for diagnosis and to detect the presence of subchorionic hematoma. Patients were followed up until spontaneous abortion or up to delivery of the fetus. The measures used for the analysis were maternal age, parity, gestational age at the time of presentation, previous abortions, presence of subchorionic hematoma, complete abortion, continuation of pregnancy, antepartum hemorrhage, intrauterine growth retardation and intrauterine death of fetus. Results Out of 70 cases subchorionic haematoma was found in 30 (42.9%) cases. There were 12 (17.1%) patients who spontaneously aborted after diagnosis of threatened abortion during hospital stay, 5 (7.1%) aborted on subsequent visits while 53 (75.8%) continued pregnancy till term. Among those who continued pregnancy intrauterine growth retardation was seen in 7 (13.2%), antepartum hemorrhage in 4 (7.5%), preterm premature rupture of membrane in 3 (5.66%) and IUD in 3 (5.66%). Spontaneous abortion was found more in cases with subchorionic hematoma of size more than 20 cm2. Conclusion In cases of threatened abortion with or without the presence of subchorionic hematoma, prognostic outcome is better following treatment with bed rest, uterine sedatives, folic acid supplementation and hormonal treatment.http://dx.doi.org/10.3126/kumj.v9i1.6261 Kathmandu Univ Med J 2011;9(1):41-4

Moderate Caffeine Use and the Risk of Spontaneous Abortion and Intrauterine Growth Retardation

1993 ◽  
Vol 48 (7) ◽  
pp. 448-450
Author(s):  
James L. Mills ◽  
Lewis B. Holmes ◽  
Jerome H. Aarons ◽  
Joe Leigh Simpson ◽  
Zane A. Brown ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Intrauterine Growth

Increased lipolysis but diminished gene expression of lipases in subcutaneous adipose tissue of healthy young males with intrauterine growth retardation

2011 ◽  
Vol 111 (6) ◽  
pp. 1863-1870 ◽  
Author(s):  
Lise Højbjerre ◽  
Amra C. Alibegovic ◽  
Mette P. Sonne ◽  
Flemming Dela ◽  
Allan Vaag ◽  
...  
Keyword(s):  
Blood Flow ◽  
Adipose Tissue ◽  
Mrna Expression ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Bed Rest ◽  
Whole Body ◽  
Intrauterine Growth ◽  
Glucose Clamp Technique

Intrauterine growth retardation (IUGR) is associated with a central fat distribution and risk of developing type 2 diabetes in adults when exposed to a sedentary Western lifestyle. Increased lipolysis is an early defect of metabolism in IUGR subjects, but the sites and molecular mechanisms involved are unknown. Twenty IUGR and 20 control (CON) subjects, aged 20–30 years, were studied before and after 10 days of bed rest using the glucose clamp technique combined with measurements of in vivo metabolism by microdialysis technique and blood flow by 133Xe washout technique in subcutaneous abdominal (SCAAT) and femoral (SCFAT) adipose tissue. Additionally, mRNA expression of lipases was evaluated in biopsies from SCAAT. Lipolysis in SCAAT was substantially higher in IUGR than in CON subjects despite markedly lower mRNA expression of lipases. Blood flow was higher in IUGR compared with CON in both SCAAT and SCFAT. Whole body insulin sensitivity did not differ between groups and decreased after bed rest. After bed rest, SCAAT lipolysis remained higher in IUGR compared with CON, and SCFAT lipolysis decreased in CON but not in IUGR. Prior to the development of whole body insulin resistance, young men with IUGR are characterized by increased in vivo adipose tissue lipolysis and blood flow with a paradoxically decreased expression of lipases compared with CON, and 10 days of physical inactivity underlined the baseline findings. Subjects with IUGR exhibit primary defects in adipose tissue metabolism.

Neonatal aspects of intrauterine growth retardation

1991 ◽  
Vol 3 (1) ◽  
pp. 73-85 ◽  
Author(s):  
David I Tudehope
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Perinatal Asphyxia ◽  
Neonatal Morbidity ◽  
Intrauterine Death ◽  
Intrauterine Growth ◽  
Technical Advances

The growth-retarded fetus is susceptible to intrauterine death, perinatal asphyxia and subsequently neonatal morbidity. Recent technical advances have only moderately increased the obstetrician's ability to recognize the fetus with intrauterine growth retardation (IUGR) prior to delivery, compared with two decades ago when less than one-third of such infants were identified before labour and delivery.

Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation

1993 ◽  
Vol 42 (3) ◽  
pp. 328-328
Author(s):  
J.L. Mills ◽  
L.B. Holmes ◽  
J.H. Aarons ◽  
J.L. Simpson ◽  
Z.A. Brown ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Intrauterine Growth
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