Aflibercept for Vascularised Serous Pigment Epithelial Detachment: One-Year Anatomical and Functional Results

Purpose: To assess the effect of intravitreal aflibercept on pigment epithelial detachment (PED) secondary to occult choroidal neovascularization (CNV) in treatment-naive patients. Patients and methods: Retrospective analysis of thirty-six patients (thirty-eight eyes) with mean age 77 (SD ± 7), who were treated with aflibercept 2.0 mg (Eylea, Bayer) at the Department of Ophthalmology of 1st Faculty of Medicine of the Charles University and the Military University Hospital Prague. All patients were treated in fixed regimen, which means 3 loading doases 1 month apart, followed by further 2-monthly doses over total 12-month period. Best corrected visual acuity (BCVA) was evaluated on Early Treatment Diabetic Retinopathy Study (ETDRS) charts. Diameters as PED height, width and central retinal thickness (CRT) were assesed using spectral-domain optical coherence tomography. All previously mentioned were analyzed et the baseline and than at every visit. Therapy complications were also evaluated. Results: Borderline significant improvement in the mean of BCVA score of 3.2 letters (SD ± 11.6, p = 0.05) at the end of follow-up period was observed. Mean PED height at 12 months significantly decreased by 140 µm (SD ± 238, p < 0.01). Reductions in PED height were correlated with reductions in central macular thickness (R = 0.94, p < 0.001) simultaneously with PED width (R = 0.45, p < 0.01). There was no significant correlation between PED height decrease and visual acuity. PED rupture was observed in 3 eyes (8 %). Conclusion: Aflibercept intravitreal therapy in fixed regimen in patients with PED secondary to occult CNV shows great anatomical effect. However, correlation between PED diameters and visual acuity was not observed.

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Ranibizumab for vascularized pigment epithelial detachment: 1-year anatomic and functional results

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-016-3564-y ◽

2016 ◽

Vol 255 (4) ◽

pp. 743-751 ◽

Cited By ~ 7

Author(s):

Olivier Chevreaud ◽

Hassiba Oubraham ◽

Salomon Y. Cohen ◽

Camille Jung ◽

Rocio Blanco-Garavito ◽

...

Keyword(s):

Functional Results ◽

Pigment Epithelial Detachment ◽

Pigment Epithelial

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Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40

Ophthalmologica ◽

10.1159/000337251 ◽

2012 ◽

Vol 228 (2) ◽

pp. 102-109 ◽

Cited By ~ 22

Author(s):

Takayuki Baba ◽

Masayasu Kitahashi ◽

Mariko Kubota-Taniai ◽

Toshiyuki Oshitari ◽

Shuichi Yamamoto

Keyword(s):

Visual Acuity ◽

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Pigment Epithelial Detachment ◽

Pigment Epithelial ◽

Age Related ◽

Better Than

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PHACOEMULSIFICATION

The Professional Medical Journal ◽

10.29309/tpmj/2016.23.11.1774 ◽

2016 ◽

Vol 23 (11) ◽

pp. 1422-1428

Author(s):

Faheem Ahmad ◽

Syeda Iqra Iqbal

Keyword(s):

Visual Acuity ◽

Case Series ◽

Visual Outcome ◽

University Hospital ◽

Complication Rates ◽

Basic Training ◽

Ophthalmic Surgery ◽

Counting Finger ◽

Good Visual Outcome ◽

One Year

Introduction: Any opacity in crystalline clear lens that may or maynot impaired vision is called cataract. According to maturity of cataract it may beimmature, mature or hypermature. When a patient develop cataract than there isno significant medical treatment for cataract. Surgery is the treatment of choice forcataract. Phacoemulsification (phaco), a modification of ECCE, has found worldwidepopularity in last two decades. Objectives: To find out visual acuity and complicationsof phacoemulsification in patients operated by senior surgeon during learning curve.Study Design: Descriptive case series. Settings: Department of OphthalmologyIndependent University Hospital, Faisalabad. Period: One year from 01-04-2014to 31-03-2015. Data Collection Methods: Patients coming through the OPD ofthe eye department who fulfilled the inclusion criteria were enrolled and informedconsent was taken from all patients. Results: In this study 100 eyes had undergonePhacoemulsification with IOL under Local anesthesia during study period. The meanage of patients was 57.50 years (range 30-85 years). Regarding the visual acuity inoperated eyes, 80 eyes ( 80 %) had a BCVA of 6/6-6/12, 12 eyes (12 %) had a BCVA of6/18 to 6/36 and 6 eyes (6 %) had a BCVA of 6/60 to CF. While only 2 percent Patienthad visual acuity less than Counting finger(CF). Discussion: During phaco training,the author was taught in stepwise about various stages of phaco and then authorpractice single part every stage of phaco multiple times to be master in every step ofphaco under supervision of an experienced ophthalmologist. Due to learning of phacostep-by-step leads to good surgical outcomes and least complication rates. Afterlearning the phaco basic training, the author started to perform phacoemulsification inIndependent University Hospital Faisal Abad under the supervision of an experiencedophthalmologist followed by independently performing phacoemulsification.Conclusion: Surgeon experienced in ophthalmic surgery along with adequatephacoemulsification training leads to a good visual outcome with minimum peroperativeand post-operative complications.

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Morphologic Changes in Patient with Drusen and Drusenoid Pigment Epithelial Detachment after Intravitreal Ranibizumab for Choroidal Neovascular Membrane : A Case Report

The Open Ophthalmology Journal ◽

10.2174/1874364101610010001 ◽

2016 ◽

Vol 10 (1) ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Sukjin Kim ◽

Jeongjae Oh ◽

Kiseok Kim

Keyword(s):

Visual Acuity ◽

Case Report ◽

Age Related Macular Degeneration ◽

Pigment Epithelial Detachment ◽

Choroidal Neovascular Membrane ◽

Intravitreal Ranibizumab ◽

Pigment Epithelial ◽

Age Related ◽

The Right ◽

Morphologic Changes

The authors present a case of morphologic changes of drusen and drusenoid pigment epithelial detachment (DPED) after treating choroidal neovascularization (CNV) using ranibizumab in age-related macular degeneration (AMD). A 71-year-old woman has noticed mild visual acuity deterioration in the right eye for several months. She was presented with some drusen and DPED associated with CNV. This patient was given intravitreal injection of 0.5 mg of ranibizumab five times at monthly intervals for treating CNV. DPED in the temporal and drusen in the superior to macula were diminished, which continued up to 2 months. Intravitreal ranibizumab injection may have influenced with diminishment of drusen and DPED. After 2 months, CNV was recurred.

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One year results of anti-VEGF treatment in pigment epithelial detachment secondary to macular degeneration

Arquivos Brasileiros de Oftalmologia ◽

10.1590/s0004-27492013000400002 ◽

2013 ◽

Vol 76 (4) ◽

pp. 209-211 ◽

Cited By ~ 5

Author(s):

Harun Yüksel ◽

Fatih M. Türkcü ◽

Alparslan Şahin ◽

Muhammed Şahin ◽

Yasin Çinar ◽

...

Keyword(s):

Macular Degeneration ◽

Pigment Epithelial Detachment ◽

Pigment Epithelial ◽

Anti Vegf ◽

One Year

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The Correlation between Corneal Findings and Disease Severity in Keratoconus per Scheimpflug Corneal Tomography

Journal of Ophthalmology ◽

10.1155/2020/4130643 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Ahmed E. M. Shehata ◽

James W. Foster ◽

Albert S. Jun ◽

Uri S. Soiberman

Keyword(s):

Visual Acuity ◽

Disease Severity ◽

Clinical Signs ◽

Case Series ◽

Final Analysis ◽

Atopic Disease ◽

Senior Author ◽

Treatment Naïve ◽

One Year ◽

Corneal Tomography

Purpose. This study aims to correlate the clinical signs of keratoconus (KC) which include superficial apical scarring, Fleischer rings, and Vogt striae with best spectacle-corrected visual acuity (BSCVA) and corneal tomography findings. Patients and methods. A retrospective observational study. 72 consecutive KC patients seen by the senior author over the course of one year were included in this case series. Eyes with pellucid marginal degeneration, postrefractive ectasia, history of a corneal graft, prior corneal collagen cross-linking, intracorneal ring segments or hydrops were excluded from analysis. Subsequently, the final analysis included only treatment-naïve KC eyes with varying degrees of disease severity. Results. BSCVA with manifest refraction was 0.5 logMAR higher in eyes with apical scarring (p<0.001). Eyes with apical scarring had worse vision than eyes with Fleischer rings alone (0.43 logMAR higher in the former, p<0.009). Eyes with apical scarring had higher keratometry readings (K2 = 64.56 ± 12.89 D versus 49.07 ± 6.61 D, p<0.001); this was also true for eyes with Fleischer rings compared with ring-free eyes (K2 = 56.23 ± 11.52 D versus 48.91 ± 7.79 D, p<0.001) and eyes with Vogt striae (K2 = 56.19 ± 10.27 D versus 50.68 ± 9.21 D, p=0.01). Atopic disease was a risk factor for scarring: odds ratio (OR) = 2.87 (p=0.03). The OR of observing Fleischer rings in KC eyes was 12% per year (p=0.001). Additionally, each mm of corneal apex displacement from the pupillary center led to a 0.76 logMAR increase in visual acuity (p=0.001). Conclusion. The presence of apical scarring and Fleischer rings on biomicroscopy can aid the clinician in making the distinction between severe or long-standing disease (respectively). Apical scarring is a sign of advanced disease and is associated with worse BSCVA and tomography findings. Fleischer rings are markers of intermediate disease and their presence correlates with disease duration.

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