Phase transition in tumor growth VIII: The spatiotemporal of avascular evolution

A 2D cellular automata model, which allows a better understanding of the morphogenesis of the avascular tumor pattern formation, is presented. Using thermodynamics formalism of irreversible processes and results of complex systems theory, we propose markers to able to establish, in a quantitative way, the degree of aggressiveness and the malignancy of tumor patterns, such as a fractal dimension and the entropy production rate.