Efficacy of γ-linolenic Acid and Thioctic Acid in Patients With Diabetic Neuropathy

Thioctic acid tromethamol salt (thioctacide 600, ASTA Medica, Germany) was used in the treatment of 20 diabetics with type 1 disease with pronounced diabetic neuropathy (DN). The drug was injected intravenously by drip infusion in 200 ml 0.9% sodium chloride for 3 weeks (5 times a week with 2-day intervals), after which it was given orally, I tablet 30 min before breakfast for 4-8 weeks. After the course essential improvement was observed in all the patients. According to the questionnaires, pain decreased by 64%, and according to DN score 2.3 times. Elec-troneuromyographic parameters improved significantly, cardiac rhythm variability increased in 67% patients with stable heartbeat. In the placebo group 50% patients noted improvement, but it was far less expressed. Hence, the study demonstrated a high efficiency of thioctacide in the treatment of patients with DN.

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Comments on "Treatment of diabetic neuropathy with -linolenic acid" by The -Linolenic Multicenter Trial Group

Diabetes Care ◽

10.2337/diacare.16.9.1309a ◽

1993 ◽

Vol 16 (9) ◽

pp. 1309-1309 ◽

Cited By ~ 1

Author(s):

T. M. S. Wolever

Keyword(s):

Diabetic Neuropathy ◽

Linolenic Acid ◽

Multicenter Trial ◽

Trial Group

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GAMMA-LINOLENIC ACID IN DIABETIC NEUROPATHY

The Lancet ◽

10.1016/s0140-6736(86)91365-6 ◽

1986 ◽

Vol 327 (8489) ◽

pp. 1098 ◽

Cited By ~ 25

Author(s):

G JAMAL

Keyword(s):

Diabetic Neuropathy ◽

Linolenic Acid ◽

Gamma Linolenic Acid

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Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy

Revista de Chimie ◽

10.37358/rc.19.10.7607 ◽

2019 ◽

Vol 70 (10) ◽

pp. 3614-3617

Author(s):

Andreea Rotaru ◽

Carmen Valeria Albu ◽

Diana Rodica Tudorascu ◽

Bogdan Catalin ◽

Mihaela Gheonea ◽

...

Keyword(s):

Diabetic Neuropathy ◽

Acid Treatment ◽

Prospective Observational Study ◽

Vitamin B ◽

Thioctic Acid ◽

Common Cause ◽

Peripheral Diabetic Neuropathy ◽

Therapeutic Protocol ◽

Peripheral Polyneuropathy

Diabetic neuropathy is the most common cause of neuropathy worldwide and it is estimated to affect about half of people with diabetes. The goal of our study is to compare the effectiveness of thioctic acid treatment alone versus the efficacy of thioctic acid plus vitamin B complex in patients with diabetic peripheral polyneuropathy (DPN). We conducted a prospective, observational study staring from October 2017 to December 2018, in which we included 56 DPN patients. Depending on the Michigan neuropathic screening instrument (MNSI) we divided the patients into two subgroups: patients with MNSI [7 and patients whose MNSI did not decrease sufficiently during the therapeutic protocol. 36 patients (64.2%) of the total patients enrolled in the study had an MNSI [7 at one of the follow-up meetings. These patients were also divided according to the therapeutic protocol applied in a group of patients who were treated with only thioctic acid (TA group) and in a group of patients who were treated with thioctic acid plus vitamin B complex (TA + B group). We noticed a greater proportion of patients who had a MNSI [7 in the TA + B group. This study revealed that the treatment of peripheral diabetic neuropathy with thioctic acid plus Vitamin B complex compared to thioctic acid alone was superior in terms of improving clinical features.

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