Pre-Approval Access to Golimumab Subcutaneous for the Treatment of Stage 3 Type-1 Diabetes Mellitus in Children and Young Adults

OBJECTIVE: To evaluate serum leptin levels in children and young adults with type 1 (insulin-dependent) diabetes mellitus and to investigate whether they are different in prepuberty, puberty and young adulthood. DESIGN: Three groups of diabetics (prepubertal, pubertal and young adults) subdivided into obese and non-obese were studied. Three groups of healthy subjects matched for sex, age and body mass index served as controls. RESULTS: Diabetic patients had serum leptin concentrations similar to those of controls in all three groups. A small non-significant increase in leptin from the prepubertal to the young adult age group for both diabetics and controls was found. A significant association of serum leptin level with body mass index (P < 0.001), female sex (P < 0.001) and age (P < 0.01) in both the diabetic and control group was present. Insulin-dependent diabetes was not associated with higher leptin concentration. CONCLUSIONS: Serum leptin concentrations are similar in diabetic patients and healthy controls. The association between obesity and leptin concentration was similar in the diabetic and non-diabetic subjects. Type 1 diabetes mellitus does not modify serum leptin concentration.

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The Neurocognitive Effects of Type 1 Diabetes Mellitus in Children and Young Adults With and Without Hypoglycemia

Journal of Developmental and Physical Disabilities ◽

10.1007/s10882-009-9151-y ◽

2009 ◽

Vol 21 (5) ◽

pp. 425-440 ◽

Cited By ~ 14

Author(s):

Priscilla A. Bade-White ◽

John E. Obrzut

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Young Adults ◽

Type 1 Diabetes Mellitus ◽

Children And Young Adults

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Host and Environmental Factors Defining the Epidemiology of Type 1 Diabetes Mellitus in a Group of Lebanese Children and Young Adults

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem.2003.16.5.759 ◽

2003 ◽

Vol 16 (5) ◽

Cited By ~ 4

Author(s):

P.A. Zalloua ◽

H. Terwedow ◽

H. Shbaklo ◽

G. Halaby ◽

X. Xu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Young Adults ◽

Environmental Factors ◽

Type 1 Diabetes Mellitus ◽

Children And Young Adults

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Autoimmune thyroid disease in Libyan children and young adults with type 1 diabetes mellitus

European Journal of Pediatrics ◽

10.1007/s00431-010-1386-1 ◽

2011 ◽

Vol 170 (8) ◽

pp. 983-987 ◽

Cited By ~ 11

Author(s):

Millad Ghawil ◽

Elio Tonutti ◽

Sulieman Abusrewil ◽

Daniela Visentini ◽

Ibtisam Hadeed ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Young Adults ◽

Type 1 Diabetes Mellitus ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Autoimmune Thyroid ◽

Children And Young Adults

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Alcohol Use in Young Adults With Type 1 Diabetes Mellitus

American Journal of Lifestyle Medicine ◽

10.1177/1559827617722137 ◽

2017 ◽

Vol 11 (6) ◽

pp. 433-435 ◽

Cited By ~ 3

Author(s):

Nicole D. White

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Young Adults ◽

Glucose Metabolism ◽

Alcohol Use ◽

Adverse Effects ◽

Type 1 Diabetes Mellitus ◽

Acute Ingestion ◽

Chronic Ingestion

Although fewer individuals with type 1 diabetes mellitus (T1DM) drink alcohol, the potential and severity of harm associated with its consumption is higher in persons with diabetes. Alcohol use affects glucose metabolism and results in various potential adverse effects both from acute ingestion and chronic ingestion in persons with T1DM. The purpose of this article is to describe the effects of alcohol on glucose metabolism and diabetes control in persons with T1DM and propose counseling pearls for providers working with patients in this population.

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