Quinine Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery

2019 ◽  
Author(s):  
Keyword(s):  
Nasal Spray ◽  
Endoscopic Sinus Surgery ◽  
Sinus Surgery

scholarly journals A randomized control study to compare the efficacy of intranasal fluticasone propionate and intranasal budesonide in controlling postoperative symptoms in patients with nasal polyposis after endoscopic sinus surgery

2019 ◽  
Vol 9 (36) ◽  
pp. 182-186
Author(s):  
Kiruba Shankar ◽  
Satvinder Singh Bakshi ◽  
Sunil Kumar Saxena ◽  
Suriyanarayanan Gopalakrishnan
Keyword(s):  
Fluticasone Propionate ◽  
Nasal Spray ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyposis ◽  
Sinus Surgery ◽  
Endoscopic Polypectomy ◽  
Chronic Inflammatory Condition ◽  
Intranasal Steroids ◽  
Postoperative Symptoms ◽  
Sinonasal Polyposis

Abstract BACKGROUND. Sinonasal polyposis represents a chronic inflammatory condition characterized by nasal obstruction, reduction in the sense of smell and impaired quality of life. Intranasal steroids play an important role in preventing the postoperative recurrences in these cases. We carried out a study to evaluate and compare intra nasal budesonide and intranasal fluticasone propionate in the postoperative management of ethmoidal nasal polyposis. MATERIAL AND METHODS. 106 patients with ethmoidal polyposis were treated with endoscopic polypectomy and were postoperatively started and maintained on intranasal steroids. 54 patients were managed with budesonide and 52 patients maintained on fluticasone propionate nasal spray. The patients were followed-up for 6 months and recurrences and control of symptoms evaluated. RESULTS. There was a statistical difference in the SNOT-22 (p<0.0001) and Lund-Kennedy scores (p=0.015) between patients using fluticasone propionate as compared to those using budesonide intra nasal spray by the end of the 6th month. CONCLUSION. Both intranasal budesonide and fluticasone propionate are effective in controlling symptoms after endoscopic sinus surgery in patients with sinonasal polyposis; however, intranasal fluticasone propionate was more efficacious than budesonide in the control of postoperative symptoms.

scholarly journals Efficacy of Carragelose® Nasal Spray Impregnated Versus Mupirocin Ointment Impregnated Nasal Packs on Mucosal Healing after Endoscopic Sinus Surgery: A Double-Blind, Non-Randomized, Right-Left Side Comparison

2020 ◽  
Vol 35 (2) ◽  
pp. 11
Author(s):  
Joseph Bernard Lo ◽  
Emmanuel Tadeus Cruz
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Spray ◽  
Endoscopic Sinus Surgery ◽  
Scoring System ◽  
Nasal Polyposis ◽  
Mucosal Healing ◽  
Sinus Surgery ◽  
Double Blind ◽  
Mupirocin Ointment ◽  
Sinus Endoscopy

ABSTRACTObjective: To determine the efficacy of carragelose® nasal spray versus mupirocin ointment impregnated nasal packs on postoperative mucosal healing among chronic rhinosinusitis with nasal polyposis (CRSwNP) patients after endoscopic sinus surgery (ESS). Methods:Design: Double-Blind, Non-Randomized, Right-Left Side ComparisonSetting: Tertiary Government Training HospitalParticipants: Fifteen (15) patients diagnosed with chronic rhinosinusitis with nasal polyposis (CRSwNP) who had ESS were included in the study. Nasal packs (Netcell®) impregnated with carragelose® nasal spray or mupirocin ointment were respectively applied in right and left nostrils. Postoperative mucosal healing was graded by a blinded consultant using the Lund-Kennedy Endoscopic Scoring System and Perioperative Sinus Endoscopy (POSE) scoring system. Results: Six patients (12 nasal sides) completed the study. Comparing nasal packs impregnated with carragelose® nasal spray mupirocin ointment, the carragelose® group had lower Lund- Kennedy median scores than the mupirocin group on the 7th post-operative day; and this was statistically significant (p = .027). There were no significant differences in Lund-Kennedy postoperative scores on days 4 (p = .217), 14 (p = .171) and 28 (p = .151). Conclusion: Carragelose®  nasal spray impregnated nasal packs may be comparable with, and may be an alternative to mupirocin ointment impregnated nasal packs in terms of postoperative mucosal healing among ESS patients with CRSwNP.

The Effect of Functional Endoscopic Sinus Surgery on Nasal Spray Distribution to the Middle Meatus in Patients with Rhinosinusitis

2009 ◽  
Vol 23 (5) ◽  
pp. 546-548 ◽  
Author(s):  
Alexandros Tsikoudas ◽  
Martyn L. Barnes ◽  
Paul S. White
Keyword(s):  
Nasal Spray ◽  
Endoscopic Sinus Surgery ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Teaching Hospitals ◽  
Blue Dye ◽  
Middle Meatus ◽  
Nasal Drug Delivery ◽  
Old Patients ◽  
Spray Absorption

Background Because the principle behind functional endoscopic sinus surgery (FESS) recognizes the middle meatus as essential for the control of the disease, the effect of the operation in the distribution of drugs in the same area should be of similar importance. This study was designed to clarify whether nasal drug delivery is improved in patients after FESS. The study involved a prospective assessment within subject comparison. The subjects were 20 adult (>18 years old) patients on the waiting list for FESS. It was conducted within two teaching hospitals in the East of Scotland. Methods A novel method was used, positioning a neurosurgical patty in the middle meatus and assessing blue dye nasal spray absorption on a 4-point scale. Results A significant improvement was observed in the distribution of the indicator in the middle meatus postoperatively. Seventy percent of the patients showed improvement in the drug distribution after FESS. The median result for absorption score was 2 preoperatively (<50%) and 3 postoperatively (>50%). The difference was statistically significant (p < 0.001). Conclusion The distribution of nasal drugs is improved in the middle meatus after FESS. This can have important clinical applications that can benefit patients in otolaryngology as well as other disciplines.

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