Clinical Study on the Safety and Effectiveness of Vagus Nerve Stimulation in the Treatment of Refractory Depression

2019 ◽  
Author(s):  
Keyword(s):  
Clinical Study ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Refractory Depression

P.2.a.019 Memory and executive functions in patients treated with vagus nerve stimulation for refractory depression

2010 ◽  
Vol 20 ◽  
pp. S344
Author(s):  
V. Desbeaumes ◽  
F. Richer ◽  
E. LaGarde ◽  
S. Patry ◽  
A. Bouthillier ◽  
...  
Keyword(s):  
Executive Functions ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Refractory Depression

Long-term Sustained Cognitive Benefits of Vagus Nerve Stimulation in Refractory Depression

2018 ◽  
Vol 34 (4) ◽  
pp. 283-290 ◽  
Author(s):  
Véronique Desbeaumes Jodoin ◽  
François Richer ◽  
Jean-Philippe Miron ◽  
Marie-Pierre Fournier-Gosselin ◽  
Paul Lespérance
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Refractory Depression ◽  
Cognitive Benefits

scholarly journals Vagus nerve stimulation and refractory depression

2003 ◽  
Vol 183 (3) ◽  
pp. 181-183 ◽  
Author(s):  
Keith Matthews ◽  
Muftah S. Eljamel
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Depressive Disorders ◽  
Psychological Treatment ◽  
Antidepressant Drugs ◽  
Refractory Depression ◽  
High Prevalence ◽  
Accepted Practice ◽  
Available Information

As highlighted in the recent systematic review by Stimpson et al (2002), we know little about the relative efficacies of the treatment interventions that are routinely deployed for those with depressive disorders that have not responded to standard, first-line treatment approaches. Accepted practice is, at best, systematic ‘trial and error’, with sequential antidepressant monotherapy and/or combinations of antidepressant drugs with ‘augmenting agents'. This haphazard medicinal approach to managing the patient with poorly responsive depressive disorder is compounded by the lack of available information on the effectiveness and optimal role for psychological treatment methods. Given the high prevalence of depressive disorders and their frequent presentation to both primary and secondary care health services, it is a source of embarrassment that we remain so ignorant. Nevertheless, it is against this backdrop of uncertainty that we must now evaluate the relative merits of a novel intervention that has captured considerable media and lay interest: vagus nerve stimulation (VNS™).

Vagus Nerve Stimulation: A New Form of Therapeutic Brain Stimulation

CNS Spectrums ◽  
2000 ◽  
Vol 5 (11) ◽  
pp. 43-52 ◽  
Author(s):  
Mark S. George ◽  
Ziad Nahas ◽  
Daryl E. Bohning ◽  
Mikhael Lomarev ◽  
Stuart Denslow ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Brain Stimulation ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Sensory Information ◽  
The United States ◽  
Brain Regions ◽  
The Body ◽  
Refractory Depression ◽  
The Brain

AbstractAlthough the vagus nerve has traditionally been considered to perform efferent functions, in reality it performs significant afferent functions as well, carrying information from the body, head, and neck to the brain. Preliminary studies examining this afferent activity led to the theory that vagus nerve stimulation (VNS) could successfully control seizure activity in persons who are refractory to antiepileptic medications. Unlike other forms of brain stimulation, VNS is unable to directly stimulate multiple discrete areas of the brain; however, through several pathways, it is able to relay sensory information to higher brain regions. An implantable VNS device known as the VNS™ NeuroCybernetic Prosthesis (NCP) System has been used in approximately 9,000 epilepsy patients in Europe and the United States since 1994. The implant has reduced seizure frequency by an average of 25% to 30%, with minimal side effects. Studies underway are also showing some degree of success in the management of treatment-refractory depression. The future efficacy of the implantable system in other disorders may depend on whether the implant can be more precisely focused to affect different brain regions. Research in this area is underway.

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