Cortical and vegetative regulation of aminotransferase activity in blood serum of dry sows under exposure to a technological stimulus

2020 ◽  
Author(s):  
R. Postoi ◽  
◽  
V. Karpovskyi ◽  
A. Cherepnina ◽  
V. Postoi ◽  
...  
Keyword(s):  
Blood Serum ◽  
Significant Influence ◽  
Alanine Aminotransferase ◽  
Significant Degree ◽  
Aminotransferase Activity ◽  
Large White ◽  
White Breed ◽  
Vegetative Regulation ◽  
The Relationship ◽  
Alanine Aminotransferase Activity

The article presents the results of studying the influence of cortical and vegetative mechanisms of regulation on the transaminase enzymes activity in blood serum of dry sows under exposure to a technological stimulus. The experiments were carried out on sows of large white breed of 3 years old. The results of research have shown that the indicators of conditioned reflex activity affect the activity of reamination enzymes in blood serum both under physiological conditions and after the exposure to a technological stimulus. According to the correlation analysis, the relationship between the strength and balance of cortical processes with serum alanine aminotransferase activity (r = 0.48–0.65; Р≤0.05–0.01), as well as the strength of cortical processes with aspartate aminotransferase activity (r = 0.51; P≤0.05). The significant influence (η2x = 0.23–0.36; Р≤0.01) of the balance of cortical processes on the activity of alanine aminotransferase in blood serum was established. Instead, the tone of the autonomic nervous system had a significant influence on the activity of reamination enzymes only after the exposure to a technological stimulus. In particular, the significant degree of influence (η2x = 0.28; P≤0.05) of sympathicotonia on the activity of alanine aminotransferase in blood serum on the 7th day after exposure to a technological stimulus was established.

Delayed onset of acute renal failure after significant paracetamol overdose: A case series

2009 ◽  
Vol 29 (1) ◽  
pp. 63-68 ◽  
Author(s):  
WS Waring ◽  
H. Jamie ◽  
GE Leggett
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Serum Creatinine ◽  
Alanine Aminotransferase ◽  
Paracetamol Overdose ◽  
Peak Serum ◽  
Wilcoxon Test ◽  
Aminotransferase Activity ◽  
Baseline Serum ◽  
Alanine Aminotransferase Activity

Acute renal failure is a recognized manifestation of paracetamol toxicity, but comparatively little data is available concerning its onset and duration. The present study sought to characterize the time course of rising serum creatinine concentrations in paracetamol nephrotoxicity. Renal failure was defined by serum creatinine concentration ≥150 μmol/L (1.69 mg/dL) or ≥50% increase from baseline. Serum creatinine concentrations and alanine aminotransferase activity were considered with respect to the interval after paracetamol ingestion. There were 2068 patients with paracetamol overdose between March 2005 and October 2007, and paracetamol nephrotoxicity occurred in 8 (0.4%). All had significant hepatotoxicity, and peak serum alanine aminotransferase activity occurred at 2.5 days (2.2 to 2.9 days) after ingestion. Peak serum creatinine concentrations did not occur until 5.5 days (4.4 to 5.9 days) after ingestion (p = .031 by Wilcoxon test). Serum creatinine concentrations slowly restored to normal, and renal replacement was not required. In this patient series, rising serum creatinine concentrations only became detectable after more than 48 hours after paracetamol ingestion. Therefore, renal failure might easily be missed if patients are discharged home before this. Further work is required to establish the prevalence of paracetamol-induced nephrotoxicity, and its clinical significance.

Effect of Lactate Dehydrogenase Isoenzymes on the Coupled Enzymatic Assay for Alanine Aminotransferase Activity

1975 ◽  
Vol 21 (3) ◽  
pp. 330-333 ◽  
Author(s):  
Michael M Chang ◽  
Tai Wha Chung
Keyword(s):  
Lactate Dehydrogenase ◽  
Dehydrogenase Activity ◽  
Alanine Aminotransferase ◽  
Rabbit Muscle ◽  
Aminotransferase Activity ◽  
Lactate Dehydrogenase Activity ◽  
Enzymatic Assays ◽  
Substrate Specificities ◽  
Lactate Dehydrogenase Isoenzymes ◽  
Alanine Aminotransferase Activity

Abstract We show an example of the importance of specifying the form of isoenzyme and source of indicator enzymes to be used in coupled enzymatic assays. When we compared H4 (pig heart) and M4 (rabbit muscle) isoenzymes of lactate dehydrogenase for their suitability as indicator enzymes in the assay for alanine aminotransferase activity, we found that about fourfold as much M4 as H4 was required in terms of lactate dehydrogenase activity to reflect accurately equivalent amounts of alanine aminotransferase activity. Moreover, the substrate specificities of the two isoenzymes differed quantitatively.

Children of Latino Immigrants, 4-8 Years, in Rural Nebraska are Adequate in Vitamin B-6

2006 ◽  
Vol 76 (2) ◽  
pp. 47-56 ◽  
Author(s):  
Karina R. Lora ◽  
David W. Giraud ◽  
Sarah R. Davy ◽  
Judy A. Driskell
Keyword(s):  
Activity Coefficients ◽  
Alanine Aminotransferase ◽  
Plasma Concentrations ◽  
Immigrant Parents ◽  
Vitamin B ◽  
Latino Children ◽  
Aminotransferase Activity ◽  
Food Recalls ◽  
Alanine Aminotransferase Activity ◽  
Apparently Healthy

Plasma concentrations of B-6 vitamers and homocysteine as well as erythrocyte alanine aminotransferase activity coefficients and vitamin B-6 (dietary + supplement) intakes of apparently healthy young Latino children of immigrant parents living in rural Nebraska were determined and differences determined by gender. Thirty-five Latino children (16 males and 19 females), aged 4–8 years, were included in the study. Nutrient intake information was obtained from the children’s parents utilizing two nonconsecutive 24-hour food recalls. No differences were observed by gender with regard to vitamin B-6 intakes, plasma concentrations of B-6 vitamers and homocysteine, and erythrocyte alanine aminotransferase activity coefficients. The intakes of all children met the Recommended Dietary Allowance for vitamin B-6. Plasma pyridoxal 5’-phosphate concentrations, plasma homocysteine concentrations, and erythrocyte alanine aminotransferase activity coefficients of the children were (mean ± SD) 83.71 ± 37.35 nmol/L, 6.81 ± 1.63 µmol/L, and 1.08 ± 0.06, respectively. All the Latino children of immigrant parents in this study had values indicative of adequate vitamin B-6 status.

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