scholarly journals Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine

Author(s):  
Apasee Sooksamran ◽  
Poonnawis Sudtikoonaseth ◽  
Praneet Sajjachareonpong ◽  
Tanongkiet Tienthavorn

We present a case of febrile ulceronecrotic Mucha-Habermann disease who presented with widespread erythematous crusted papules, which rapidly progressed to ulceronecrotic lesions accompanied by fever. The serologies showed high titers of cytomegalovirus IgG (>1:3,200) and IgM (1:800). The histopathological study showed epidermal necrosis. The treatment was begun with systemic steroids and roxithromycin to which the patient did not respond. After switching the treatment to methotrexate, the patient was further complicated by getting hepatitis. Low dose cyclosporine resolved the situation within 2 weeks. In patients for whom methotrexate is contra-indicated or ineffective, cyclosporine can suppress T-lymphocyte hyperresponsiveness and resolve this disease.

2020 ◽  
Vol 2020 (7) ◽  
Author(s):  
Marah Mansour ◽  
Ola Souliman ◽  
Sawsan Ismail ◽  
Tamim Alsuliman ◽  
Fadi Souleiman

Abstract A gastric duplication cyst (GDC) is an uncommon gastrointestinal (GI) tract anomaly in adults. Nonspecific symptoms make it difficult to diagnose, while radiological examination might be helpful. However, the final diagnosis is made after eradication and histopathological study. Herein we report a case of an asymptomatic, incidentally diagnosed gastric duplication cyst discovered during laparoscopic sleeve gastrectomy in a 55-year-old female.


2021 ◽  
Vol 13 ◽  
Author(s):  
Kiran Kumar Rathinam ◽  
Sarvesh Sabarathinam ◽  
Poojith Nuthalapati ◽  
Vijayakumar Thangavel Mahalingam

Objective: To report a rare case of drug induced overlap of Stevens-Johnson syndrome and Toxic Epidermal Necrosis Syndrome exacerbated by cephalexin. Case summary: In this case report we present a 65-year-old female who had come to the hospital with complaints of Sloughing of the skin and redness all over the body with raised body temperature. She was on therapeutic Phenytoin to prevent the post-surgical complications of Communicating Hydrocephalus. After a detailed examination it was found that the patient had misemployed with an overdose of Phenytoin. The patient was found with nikolsky sign and diagnosed as Stevens-Johnson syndrome and Toxic Epidermal Necrosis overlap. This case report emphasizes phenytoin induced Stevens-Johnson syndrome and Toxic Epidermal Necrosis syndrome exacerbated by cephalexin. Practice implications: By witnessing this phenomenon, we could figure out the association between cephalexin and Stevens-Johnson syndrome- Toxic Epidermal Necrosis syndrome overlap. The Immediate dismissal of the offending agent and commencement of supportive care was found to be effective.


2014 ◽  
Author(s):  
Tadeusz Budlewski ◽  
Dorota Szydlarska ◽  
Norbert Szalus ◽  
Jolanta Kijek ◽  
Beata Ewa Chrapko

Author(s):  
Ivana Sagova ◽  
Dušan Pavai ◽  
Matej Stančik ◽  
Helena Urbankova ◽  
Juliana Gregova ◽  
...  

2011 ◽  
Vol 3 (6) ◽  
pp. 405-406
Author(s):  
Dr. Nale Swati S Dr. Nale Swati S ◽  
◽  
Dr.Ghadage Dnyaneshwari P ◽  
Bhore Arvind V

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