scholarly journals Continuous fentanyl infusion reduces intra-abdominal pressure, postoperative pain and normalizes lungs’ mechanical changes in newborn with viscera-abdominal disproportion in early post-operative period

Pain medicine ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 18-23
Author(s):  
Konstantin Bercun ◽  
Oleksandr Nazarchuk ◽  
Oleksandr Dobrovanov ◽  
Denis Surkov ◽  
Viktor Vidiščák

We aimed to study the influence of prolonged administration of fentanyl on postoperative pain, intra­ab­dominal pressure and mechanical lungs’ changes that may happen in neonates in early post­operative period. 30 newborns (in the period from January 2017 to May 2021) with gastroschisis were divided into two groups ac­cordingly to the method of analgesia (14 – morphine hydrochloride; 16 – prolonged infusion of fentanyl). Lungs’ mechanical characteristics, effectiveness of post­operative analgesia, abdominal wall relaxation was studied by monitoring of dynamic compliance (Cdyn), pressure and flow­volume loops, capnography. Apprising analgesia sta­tus, we measured hemodynamic, SаO2, blood level of cortizol, C­reactive protein (CRP), glucose, analyzed post­operative pain syndrome using visual analogue scales (VAS). Intra­abdominal pressure (IAP) was controlled by Cron. For statistic analysis we used Student’s t­test. In the group with morphine, thete was the increase of IAP by 11–12 cm H2O, being stable during some period of time, and also variable levels of pain according to VAS, the in­creasing of CRP from 0.8 ± 0.25 mg/dl by 5 mg/dl, cortisol by 674.4 nmol/l, and blood glucosae rate – 7.4 mmol/l. Periods with high traumatic effects and poor analgesia (morphine group) reasoned the increasing IAP, step by step dynamic compliance decreasing in 3.4 times, resistance increasing in 2.42 times and PIP rising till 22 cm H2O. Di­rect correlation between IAP increase and lungs’ mechanical changes took place. The study has demonstrated that prolonged administration of fentanyl prevented high increase of IAP, CRP, levels of glucose and cortizol and changes of VAS data, lungs’ mechanical characteristics.

Pain ◽  
2016 ◽  
Vol 157 (5) ◽  
pp. 1105-1113 ◽  
Author(s):  
Pierfrancesco Fusco ◽  
Vincenza Cofini ◽  
Emiliano Petrucci ◽  
Paolo Scimia ◽  
Giuseppe Paladini ◽  
...  

1999 ◽  
Vol 34 (1) ◽  
pp. 127
Author(s):  
June Kyu Lee ◽  
Jae Sung Ahn ◽  
Je Taek Jeong ◽  
Soon Tae Kwon ◽  
Whan Jeung Kim

2010 ◽  
Vol 76 (10) ◽  
pp. 1115-1118 ◽  
Author(s):  
Kristin Masukawa ◽  
Samuel E. Wilson

Chronic postoperative pain has been associated with mesh repair in meta-analysis of clinical trials. We compared the incidence of early complications, recurrence, and chronic pain syndrome in anatomic and mesh repairs in 200 patients. We defined chronic pain syndrome as pain in the inguinal area more than 3 months after inguinal hernia repair, patient referral to pain management, or necessity of a secondary procedure for pain control. The mean follow-up time was 4 years and 2 months for anatomic repair and 3 years and 7 months for mesh repair. The clinical outcomes did not reveal a significant disparity between the 100 consecutive patients who had mesh repair versus the 100 patients who had anatomic repair with regard to the incidence of superficial wound infection (0 vs 2%, P = 0.497), testicular swelling (12 vs 7%, P = 0.335), hematoma (1 vs 0%, P = 0.99), recurrence (3 vs 2%, P = 0.99), or chronic postoperative pain (4 vs 1%, P = 0.369). The anatomic procedure without mesh should continue to be offered to patients who have an initial inguinal hernia repair.


2016 ◽  
Vol 134 (4) ◽  
pp. 285-291 ◽  
Author(s):  
Eduardo Jun Sadatsune ◽  
Plínio da Cunha Leal ◽  
Rachel Jorge Dino Cossetti ◽  
Rioko Kimiko Sakata

ABSTRACT CONTEXT AND OBJECTIVES: Effective postoperative analgesia is important for reducing the incidence of chronic pain. This study evaluated the effect of preoperative gabapentin on postoperative analgesia and the incidence of chronic pain among patients undergoing carpal tunnel syndrome surgical treatment. DESIGN AND SETTINGS: Randomized, double-blind controlled trial, Federal University of São Paulo Pain Clinic. METHODS: Forty patients aged 18 years or over were randomized into two groups: Gabapentin Group received 600 mg of gabapentin preoperatively, one hour prior to surgery, and Control Group received placebo. All the patients received intravenous regional anesthesia comprising 1% lidocaine. Midazolam was used for sedation if needed. Paracetamol was administered for postoperative analgesia as needed. Codeine was used additionally if the paracetamol was insufficient. The following were evaluated: postoperative pain intensity (over a six-month period), incidence of postoperative neuropathic pain (over a six-month period), need for intraoperative sedation, and use of postoperative paracetamol and codeine. The presence of neuropathic pain was established using the DN4 (Douleur Neuropathique 4) questionnaire. Complex regional pain syndrome was diagnosed using the Budapest questionnaire. RESULTS: No differences in the need for sedation, control over postoperative pain or incidence of chronic pain syndromes (neuropathic or complex regional pain syndrome) were observed. No differences in postoperative paracetamol and codeine consumption were observed. CONCLUSIONS: Preoperative gabapentin (600 mg) did not improve postoperative pain control, and did not reduce the incidence of chronic pain among patients undergoing carpal tunnel syndrome surgery.


1989 ◽  
Vol 17 (2) ◽  
pp. 166-169 ◽  
Author(s):  
E. Hakanson ◽  
M. Bengtsson ◽  
H. Rutberg ◽  
A. M. Ulrick

Thirty-seven women undergoing elective cholecystectomy were randomised into two groups, receiving either lumbar epidural morphine (group L) or epidural morphine via the thoracic route (group T). The effect on pain relief was assessed by a visual analogue scale and included both resting pain and ‘provoked’ pain. Respiratory parameters (PEF, FEVI and FVC) were also studied. The patients were investigated preoperatively, and 4, 6, 12 and 24 hours after the start of surgery. No significant difference was observed between the groups concerning pain relief or respiratory performance. We conclude that after cholecystectomy lumbar epidural morphine is as effective as thoracic epidural morphine in relieving postoperative pain.


Author(s):  
Vanuchawan Wisuitiprot ◽  
Wasin Bumrungchaichana ◽  
Nipon Kaewtai ◽  
Arinchaya Rawangking ◽  
Suphawat Saiphanit ◽  
...  

Objective: To evaluate the effectiveness of Plai oil for treating myofascial pain syndrome.Material and Methods: One hundred and fourteen volunteers with muscle pain from myofascial pain syndrome participated in the study and had Plai oil, placebo oil and diclofenac gel applied to their shoulder and neck for 6 days. Clinical evaluation was determined using visual analogue scales, pressure threshold and cervical range of motion of neck flexion and neck extension measurements.Results: The results showed that the visual analogue scales of the 3 groups were significantly different from the baseline. The pressure threshold also increased significantly from the baseline (3.87±1.36) in the volunteers who applied Plai oil (4.42±1.34) and those who applied diclofenac gel (4.35±1.06). However, the results of treatment and placebo groups at the last follow-up were not significantly different. Interestingly, it was observed that Plai oil and placebo oil significantly increased the angle of neck flexion and extension within 3 days of application. Muscle pain treatment with Plai oil resulted in a good outcome that was no different to the outcome of applying the diclofenac gel and placebo.Conclusion: It was demonstrated that Plai oil is as effective for relieving myofascial pain as 1.0% diclofenac gel.The interpreted results of muscle pain are not fully clarified due to placebo effect and other influencing parameters. However, Plai oil also decreased muscle tension and improved the restricted range of motion. We can recommend that Plai oil can be used as an alternative topical application for muscle pain treatment.


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