scholarly journals Violation of antimitochondrial tolerance in patients with multiple repreduction failure

2019 ◽  
pp. 93-98
Author(s):  
B. V. Dons’koi ◽  
V. P. Chernyshov ◽  
K. S. Stepaniuk ◽  
K. J. Krychkov
Keyword(s):  
Immune Response ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Pregnant Women ◽  
Autoimmune Response ◽  
Implantation Failure ◽  
Repeated Implantation Failure ◽  
Shock Proteins ◽  
Antigen Structure ◽  
Specific Lipid

Mitochondria are semi-autonomic organelle that consist specific lipid and protein antigen structure. Evolutionary this structure is close to bacterial antigens (cardiolipin and heat shock proteins HSP). Immune response to pathogens can result to cross-reaction and development of proto-autoimmune and true autoimmune response in individuals with affected anti-mitochondrial tolerance. Serum from 127 healthy pregnant women (HPW), 58women with infertility (IF) and 149 patients with repeated implantation failure (RIF) (> 2) after IVF, was analyzed by ELISA for anti-Chlamidia IgG anti-HSP60 and cofactor-independent anti cardiolipin IgG (aCL). We show that in RIF patients aCL presence was significantly higher 23.9 % (34/142) than in HP women 7 % (9/127) and IF group 13.7 % (8/58). Anti-HSP60 ab was registered generally in RIF 8.6 % (11/98) while only one patient from IF group was anti-HSP60 positive 1.7 % (1/58) and any in HP group (0/127). We find the association between Anti-HSP60 and aCL ab. Patients with Anti-HSP60 ab was positive for aCL in 36.4 % (4/11) that was more frequently compared to both Anti-HSP60-negative: Chlamydia IgG positive 16.7 % (12/72) or Chlamydia IgG negative patients 10.9 % (33/302). We showed that aCL and Anti-HSP60 associated with repeated implantation failure and both reflect anti-mitochondrial tolerance dysfunction as hyper and hypo diagnostic markers.

Enhancement of Th1 immune response by CD8α+ dendritic cells loaded with heat shock proteins enriched tumor extract in tumor-bearing mice

2009 ◽  
Vol 260 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Abbas Azadmehr ◽  
Ali Akbar Pourfathollah ◽  
Zahra Amirghofran ◽  
Zuhair Mohammad Hassan ◽  
Seyed Mohammad Moazzeni
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Tumor Bearing ◽  
Tumor Extract ◽  
Shock Proteins ◽  
Th1 Immune Response

scholarly journals Immune Sensitization to the 60 kD Heat Shock Protein and Pregnancy Outcome

1997 ◽  
Vol 5 (2) ◽  
pp. 154-157 ◽  
Author(s):  
A. Neuer ◽  
S. Spandorfer ◽  
P. Giraldo ◽  
C. Mele ◽  
H. C. Liu ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Heat Shock Protein ◽  
Pregnancy Outcome ◽  
Embryo Development ◽  
Mouse Embryo ◽  
Implantation Failure ◽  
Genital Tract Infection ◽  
Shock Proteins

Heat shock proteins are highly conserved proteins present in organisms ranging from bacteria to man. They are both dominant microbial immunogens and among the first proteins produced during mammalian embryo development. Since bacterial and human heat shock proteins share a high degree of amino acid sequence homology, it has been suggested that sensitization to bacterial heat shock proteins during an infection may result in autoimmunity to human heat shock proteins. Infertile couples seeking in vitro fertilization (IVF) may have been previously sensitized to bacterial heat shock proteins as a consequence of an asymptomatic upper genital tract infection. Due to daily clinical monitoring and precisely timed fertilization these patients are an ideal study group to investigate the effect of prior sensitization to heat shock proteins on preimplantation embryo development and implantation failure. Immune sensitization at the level of the cervix to the 60 kD heat shock protein (hsp60) has been associated with implantation failure in some IVF patients. Similarly, the highest prevalence of circulating hsp60 antibodies among IVF patients was found in the sera of women whose embryos failed to develop in vitro. To more directly assess whether humoral immunity to hsp60 influenced in vitro embryo development, a mouse embryo culture model was established. Monoclonal antibody to mammalian hsp60 markedly impaired mouse embryo development in vitro. These data suggest that immune sensitization to human hsp60, possibly developed as a consequence of infection, may adversely affect pregnancy outcome in some patients.

Detection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected mice

2007 ◽  
Vol 59 (2) ◽  
pp. 137-147 ◽  
Author(s):  
Kei Amemiya ◽  
Jennifer L. Meyers ◽  
David DeShazer ◽  
Renaldo N. Riggins ◽  
Stephanie Halasohoris ◽  
...  
Keyword(s):  
Immune Response ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Host Immune Response ◽  
Burkholderia Mallei ◽  
Shock Proteins
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