scholarly journals Infusion of Long-chain Fatty Acids Varying in Saturation and Chain Length into the Abomasum of Lactating Dairy Cows

1992 ◽  
Vol 75 (6) ◽  
pp. 1517-1526 ◽  
Author(s):  
J.K. Drackley ◽  
T.H. Klusmeyer ◽  
A.M. Trusk ◽  
J.H. Clark
1995 ◽  
Vol 78 (1) ◽  
pp. 181-193 ◽  
Author(s):  
J.H. Harrison ◽  
R.L. Kincaid ◽  
J.P. McNamara ◽  
S. Waltner ◽  
K.A. Loney ◽  
...  

2012 ◽  
Vol 108 (4) ◽  
pp. 755-758 ◽  
Author(s):  
Charlotte J. Harden ◽  
Adam N. Jones ◽  
Tannia Maya-Jimenez ◽  
Margo E. Barker ◽  
Natalie J. Hepburn ◽  
...  

Long-chain fatty acids have been shown to suppress appetite and reduce energy intake (EI) by stimulating the release of gastrointestinal hormones such as cholecystokinin (CCK). The effect of NEFA acyl chain length on these parameters is not comprehensively understood. Anin vitroscreen tested the capacity of individual NEFA (C12 to C22) to trigger CCK release. There was a gradient in CCK release with increasing chain length. DHA (C22) stimulated significantly (P < 0·01) more CCK release than all other NEFA tested. Subsequently, we conducted a randomised, controlled, crossover intervention study using healthy males (n18). The effects of no treatment (NT) and oral doses of emulsified DHA-rich (DHA) and oleic acid (OA)-rich oils were compared using 24 h EI as the primary endpoint. Participants reported significantly (P = 0·039) lower total daily EI (29 % reduction) with DHA compared to NT. There were no differences between DHA compared to OA and OA compared to NT. There was no between-treatment difference in the time to, or EI of, the first post-intervention eating occasion. It is concluded that NEFA stimulate CCK release in a chain length-dependent manner up to C22. These effects may be extended to thein vivosetting, as a DHA-based emulsion significantly reduced short-term EI.


2000 ◽  
Vol 33 (13) ◽  
pp. 4690-4698 ◽  
Author(s):  
Michele B. Kellerhals ◽  
Birgit Kessler ◽  
Bernard Witholt ◽  
Alexandre Tchouboukov ◽  
Helmut Brandl

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