Subdural to subgaleal shunts: alternative treatment in infants with nonaccidental traumatic brain injury?

OBJECT The ideal treatment for subdural hematomas (SDHs) in infants remains debated. The aim of this study was to analyze the safety and efficiency of subduro-subgaleal drainage in SDH. METHODS The authors conducted a single-center open-label study between August 2011 and May 2012. Data were prospectively collected in a database and retrospectively analyzed. RESULTS Eighteen patients (male/female ratio 1.25) with a median age of 5 months were surgically treated. All had preoperative symptoms of intracranial hypertension or seizures. The SDH was bilateral in 16 cases, with a median width of 12 mm. Success of the procedure was noted in 14 of the 18 patients. There was no intraoperative complication or postoperative infection. Drainage failure was attributable to suboptimal positioning of the subdural drain in 2 cases and to migration in 1 case. CONCLUSIONS Subduro-subgaleal drainage is an efficient treatment that could be proposed as an alternative to external subdural drainage or subduroperitoneal drainage.

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Metronomic oral vinorelbine doublet chemotherapy with carboplatin in treatment of advanced lung cancer: a feasibility and safety study

F1000Research ◽

10.12688/f1000research.53560.1 ◽

2021 ◽

Vol 10 ◽

pp. 673

Author(s):

Maria Kandi ◽

Peter Meldgaard ◽

Marianne Marquard Knap

Keyword(s):

Lung Cancer ◽

Standard Dose ◽

Advanced Lung Cancer ◽

Continuous Exposure ◽

Open Label ◽

Oral Vinorelbine ◽

Female Ratio ◽

Male Female Ratio ◽

Doublet Chemotherapy ◽

Metronomic Vinorelbine

Background: Non-small cell lung cancer (NSCLC) is globally one of the most common forms of cancer. Palliative treatment is a delicate balance against toxicity and survival. Using small frequent doses of chemotherapy, metronomic regimens have been hypothesized to maintain or even improve efficacy while achieving a lower treatment-related toxicity. The mechanism is thought to result from a more continuous exposure of the tumour cells to the drugs. Treating NSCLC, this study addresses the feasibility and tolerability of carboplatin in combination with 12 weeks of daily metronomic vinorelbine. Method: Patients were included over a period of ten months. All patients had biopsy-verified incurable NSCLC and were candidates for first line chemotherapy (PD-L1<50% and no targetable mutations). This open label, non-randomized prospective safety and feasibility study was investigator initiated. Patients received up-to four cycles of standard dose carboplatin AUC 5 every third week in combination with 12 weeks of metronomic oral daily Navelbine® (20/30 mg). Patients were evaluated by CT scans after end of treatment and then every 8 weeks (+/- 1 week) until progression. Results: A total of 20 patients were included. Male/female-ratio was 4/16. Age ranged from 49-83 with a median of 70.5 years. Majority had adenocarcinoma (95%). Two patients withdrew their consent within a week. 18 patients were included in safety analysis. 13 received all four cycles. Grade 1/2 toxicity was frequently seen and included fatigue 13 (72%), diarrhoea 13 (72%), constipation/congestion 13 (72%). Grade 3 toxicities were dyspnoea 2 (11%), nausea 3 (17%) and fatigue 3 (17%). Two (11%) had grade 4 toxicity with neutropenic fever, both recovered. No grade 5 toxicity was detected. Conclusion: In treatment of NSCLC this study is the first addressing the regimen of carboplatin in combination with daily metronomic vinorelbine. We conclude that doublet chemotherapy with daily vinorelbine is safe and feasible.

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Azathloprise in refractory sprue. Results from a prospective open-label study

Gastroenterology ◽

10.1016/s0016-5085(01)81948-x ◽

2001 ◽

Vol 120 (5) ◽

pp. A392-A392 ◽

Cited By ~ 1

Author(s):

S NIVELONI ◽

A CHERNAVSKY ◽

S PEDREIRA ◽

R MAZURE ◽

H VAZQUEZ ◽

...

Keyword(s):

Open Label ◽

Open Label Study ◽

Label Study ◽

Refractory Sprue

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Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽

10.1027//0227-5910.20.2.64 ◽

1999 ◽

Vol 20 (2) ◽

pp. 64-70 ◽

Cited By ~ 5

Author(s):

Tamás Zonda

Keyword(s):

High Risk ◽

Psychiatric Disorders ◽

Suicide Rate ◽

Risk Groups ◽

The Elderly ◽

Female Ratio ◽

Suicide Notes ◽

Suicidal Intention ◽

Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

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