Long-term neuropsychological outcome of closed head injury

1979 ◽  
Vol 50 (4) ◽  
pp. 412-422 ◽  
Author(s):  
Harvey S. Levin ◽  
Robert G. Grossman ◽  
James E. Rose ◽  
Graham Teasdale

✓ Long-term recovery from severe closed head injury was investigated in predominantly young adults whose Glasgow Coma score was 8 or less at the time of admission. Of the 27 patients studied (median follow-up interval of 1 year), 10 attained a good recovery, 12 were moderately disabled, and five were severely disabled. In contrast to previous studies suggesting that intellectual ability after severe closed head injury eventually recovers to a normal level, our findings showed that residual intellectual level, memory storage and retrieval, linguistic deficit, and personal social adjustment corresponded to overall outcome. All severely disabled patients and several moderately disabled patients exhibited unequivocal cognitive and emotional sequelae after long follow-up intervals. Analysis of persistent neuropsychological deficit in relation to neurological indices of acute injury severity demonstrated the prognostic significance of oculovestibular deficit.

2021 ◽  
Author(s):  
Siobhan Lawless ◽  
David Havlicek ◽  
Craig Kelley ◽  
Elena Nikulina ◽  
Peter Bergold

Background: Acute injury following brain trauma may evolve into a chronic and progressive disorder. Assessment of chronic consequences of TBI must distinguish between effects of age and injury. Methods: C57BL/6 mice receive single closed head injury (CHI) and are analyzed at 14DPI or 180DPI for cortical atrophy and 7DPI or 180DPI for behavioral outcomes. Results: CHI induces ipsilesional atrophy at 14DPI that increases 180 DPI due to an effect of age. On open field, injured mice develop a turn bias at 180DPI not present at 7DPI. On rotarod, injured mice have shorter latencies at 7DPI, but not at 180DPI due to worsening performance of aging uninjured mice. On beam walk, both groups at 180DPI more slowly traverse a 2cm and 1cm beam than at 7DPI. Foot-faults show no significant effects of age or injury. Limb position was assessed using DeeplabcutTM markerless tracking followed by computation of absition (integral of limb displacement over time) using custom Python scripts. On the 2cm beam, age increased absition in all limbs of uninjured mice and both forelimbs of injured mice. Injury increased left hindlimb absition at 7DPI. On the 1cm beam both forelimbs and the left hindlimb of injured mice at 180DPI have larger absition than uninjured mice at 180DPI or injured mice at 7DPI. These data suggest chronic and progressive motor deficits of injured mice at 180DPI. Conclusions: A single impact produces ipsilesional cortical atrophy and chronic and progressive motor deficits. Quantitative behavioral analysis reveals deficits not seen using standard outcomes.


Brain Injury ◽  
1990 ◽  
Vol 4 (2) ◽  
pp. 147-154 ◽  
Author(s):  
Faye M. Jordan ◽  
Bruce E. Murdoch

NeuroImage ◽  
1996 ◽  
Vol 3 (3) ◽  
pp. S492
Author(s):  
B.S. Kirkby ◽  
J.D. Van Horn ◽  
G. Esposito ◽  
T.E. Goldberg ◽  
D.R. Weinberger ◽  
...  

Cortex ◽  
1997 ◽  
Vol 33 (1) ◽  
pp. 131-142 ◽  
Author(s):  
Giovanni A. Carlesimo ◽  
Maurizio Sabbadini ◽  
Antonella Loasses ◽  
Carlo Caltagirone

PEDIATRICS ◽  
1988 ◽  
Vol 81 (1) ◽  
pp. 93-97
Author(s):  
Frederick P. Rivara ◽  
Michael D. Kamitsuka ◽  
Linda Quan

The circumstances and characteristics of emergency room-treated injuries in children younger than 1 year of age were studied and unintentional injuries were compared with those caused by abuse. Unintentional injuries were seen 15 times more frequently in an emergency room than injuries caused by abuse. The majority of unintentional injuries were minor, although skull fractures and fractures of the clavicle did occur. In contrast, injuries caused by abuse were commonly multiple and severe and were more likely to result in long-term disability. Results of this study indicate that unintentional injuries are rarely serious and that closed head injury, rib or lower extremity fractures, and abdominal injuries are usually indicative of abuse.


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