Hypothalamic hamartoma successfully treated by operation

1985 ◽  
Vol 62 (2) ◽  
pp. 288-290 ◽  
Author(s):  
Yoshikazu Kyuma ◽  
Ei Kato ◽  
Kenichi Sekido ◽  
Takeo Kuwabara
Keyword(s):  
Luteinizing Hormone ◽  
Computerized Tomography ◽  
Precocious Puberty ◽  
Hypothalamic Hamartoma ◽  
Content Type ◽  
Testosterone Levels ◽  
Tomography Scan ◽  
Fine Print

✓ An 18-month-old boy was diagnosed as having a hypothalamic hamartoma. When he was 1 year old, he developed precocious puberty, and at 18 months old, endocrinological tests revealed abnormally high folliclestimulating hormone, luteinizing hormone, and testosterone levels. The center of the hamartoma was subtotally excised, as confirmed on the postoperative computerized tomography scan. Precocious puberty subsided after the operation.

Lymphomatoid granulomatosis with multiple intracranial lesions

1981 ◽  
Vol 55 (2) ◽  
pp. 293-298 ◽  
Author(s):  
Richard H. Simon ◽  
Micha Abeles ◽  
Neil J. Farber ◽  
Margaret Grunnet ◽  
Thomas G. Brennan
Keyword(s):  
Computerized Tomography ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Lymphomatoid Granulomatosis ◽  
Content Type ◽  
Autopsy Findings ◽  
Resistance To Treatment ◽  
Intracranial Lesions ◽  
Tomography Scan ◽  
Fine Print

✓ A case of lymphomatoid granulomatosis with multiple intracranial lesions is reported. Important aspects of this vasculitis are discussed, including its propensity for lymphomatous transformation, its similarity to Wegener's granulomatosis, its predilection for certain sites, and its resistance to treatment. A correlation is described between the computerized tomography scan and the autopsy findings.

Index for optimum ventricular catheter length

1991 ◽  
Vol 75 (1) ◽  
pp. 152-153
Author(s):  
Semih İ. Keskil ◽  
Necdet Çeviker ◽  
Kemali Baykaner ◽  
Hizir Alp
Keyword(s):  
Computerized Tomography ◽  
Head Circumference ◽  
Intraoperative Ultrasound ◽  
Ventricular Catheter ◽  
Considerable Time ◽  
Optimum Length ◽  
Content Type ◽  
The Individual ◽  
Tomography Scan ◽  
Fine Print

✓ The optimum length of a ventricular catheter to be placed in a particular patient may be difficult to determine when either intraoperative ultrasound is not available or considerable time has elapsed between the diagnostic computerized tomography scan and the operation. An index for estimating ventricular length based on the head circumference of the individual is described. This method was tested clinically and proved to be successful.

Gamma knife surgery for hypothalamic hamartomas accompanied by medically intractable epilepsy and precocious puberty: experience in Mexico

2005 ◽  
Vol 102 ◽  
pp. 53-55 ◽  
Author(s):  
Marco A. Barajas ◽  
Maria G. Ramírez-Guzmán ◽  
Carlos Rodríguez-Vázquez ◽  
Vinicio Toledo-Buenrostro ◽  
Abel Cuevas-Solórzano ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Precocious Puberty ◽  
Intractable Epilepsy ◽  
Gamma Knife Surgery ◽  
Sleep Cycle ◽  
Hypothalamic Hamartoma ◽  
High Morbidity ◽  
Content Type ◽  
Hypothalamic Hamartomas ◽  
Fine Print

Object.Hypothalamic hamartoma is a nonneoplastic malformative mass of neurons and glia in the region of the hypothalamus. Because of its location, open surgery is associated with high morbidity and mortality rates. Gamma knife surgery (GKS) may be an efficient and safe treatment approach, which produces little morbidity. The authors describe the results of GKS in three patients with hypothalamic hamartomas.Methods.All patients were male, aged 3, 12, and 15 years. The lesions were classified according to the Valdueza scale: one was Type IIb and two were Type IIa. The patients presented with gelastic seizures (15–20 per day), generalized epilepsy, behavioral abnormalities, and alterations of the sleep cycle. Precocious puberty was present in one patient. The Type IIb tumor had a volume of 1.8 cm3, and the Type IIa tumors were 597 mm3and 530.1 mm3. The lesions received 12.5 Gy, 14 Gy, and 15 Gy, respectively, to the 50% isodose line. The patients were followed for 30 to 50 months. After 3 months, all patients showed improvement of their sleep, behavior, and epilepsy. At the present time, these patients are receiving low-dose antiepileptic agents and have achieved adequate social development and school integration.Conclusions.Gamma knife surgery appears to be a good, safe, and effective option for the treatment of selected hypothalamic hamartomas. No morbidity or mortality was associated with these three cases.

The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma

1999 ◽  
Vol 91 (2) ◽  
pp. 212-220 ◽  
Author(s):  
Kazunori Arita ◽  
Fusao Ikawa ◽  
Kaoru Kurisu ◽  
Masayuki Sumida ◽  
Kunyu Harada ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Magnetic Resonance ◽  
Precocious Puberty ◽  
Third Ventricle ◽  
Clinical Manifestations ◽  
Hypothalamic Hamartoma ◽  
Content Type ◽  
The Third ◽  
The Relationship ◽  
Fine Print

Object. Hypothalamic hamartoma is generally diagnosed based on its magnetic resonance (MR) imaging characteristics and the patient's clinical symptoms, but the relationship between the neuroradiological findings and clinical presentation has never been fully investigated. In this retrospective study the authors sought to determine this relationship.Methods. The authors classified 11 cases of hypothalamic hamartoma into two categories based on the MR findings. Seven cases were the “parahypothalamic type,” in which the hamartoma is only attached to the floor of the third ventricle or suspended from the floor by a peduncle. Four cases were the “intrahypothalamic type,” in which the hamartoma involved or was enveloped by the hypothalamus and the tumor distorted the third ventricle.Six patients with the parahypothalamic type exhibited precocious puberty, which was controlled by a luteinizing hormone—releasing hormone analog, and one patient was asymptomatic. No seizures or mental retardation were observed in this group. All patients with the intrahypothalamic type had medically intractable seizures, and precocious puberty was seen in one. Severe mental retardation and behavioral disorders including aggressiveness were seen in two patients. The seizures were controlled in only one patient, in whom stereotactically targeted irradiation of the lesion was performed.This topology/symptom relationship was reconfirmed in a review of 61 reported cases of hamartoma, in which the MR findings were clearly described. The parahypothalamic type is generally associated with precocious puberty but is unaccompanied by seizures or developmental delay, whereas the intrahypothalamic type is generally associated with seizures. Two thirds of patients with the latter experience developmental delays, and half also exhibit precocious puberty.Conclusions. Classification of hypothalamic hamartomas into these two categories based on MR findings resulted in a clear correlation between symptoms and the subsequent clinical course.

CT characteristics of sacral perineural cysts

1984 ◽  
Vol 61 (3) ◽  
pp. 596-598 ◽  
Author(s):  
Edir B. Siqueira ◽  
Leslie Schaffer ◽  
Leonard I. Kranzler ◽  
Joseph Gan
Keyword(s):  
Computerized Tomography ◽  
Content Type ◽  
Additional Investigation ◽  
Neoplastic Lesion ◽  
Proper Diagnosis ◽  
Tomography Scan ◽  
Fine Print

✓ The authors report two cases in which the appearance of sacral perineural cysts, as seen in the computerized tomography scan, prompted the possible diagnosis of a neoplastic lesion. Additional investigation led to the proper diagnosis.

Gamma knife surgery for hypothalamic hamartomas accompanied by medically intractable epilepsy and precocious puberty: experience in Mexico

2005 ◽  
Vol 102 (Special_Supplement) ◽  
pp. 53-55 ◽  
Author(s):  
Marco A. Barajas ◽  
Maria G. Ramírez-Guzmán ◽  
Carlos Rodríguez-Vázquez ◽  
Vinicio Toledo-Buenrostro ◽  
Abel Cuevas-Solórzano ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Precocious Puberty ◽  
Intractable Epilepsy ◽  
Gamma Knife Surgery ◽  
Sleep Cycle ◽  
Hypothalamic Hamartoma ◽  
High Morbidity ◽  
Content Type ◽  
Hypothalamic Hamartomas ◽  
Fine Print

Object. Hypothalamic hamartoma is a nonneoplastic malformative mass of neurons and glia in the region of the hypothalamus. Because of its location, open surgery is associated with high morbidity and mortality rates. Gamma knife surgery (GKS) may be an efficient and safe treatment approach, which produces little morbidity. The authors describe the results of GKS in three patients with hypothalamic hamartomas. Methods. All patients were male, aged 3, 12, and 15 years. The lesions were classified according to the Valdueza scale: one was Type IIb and two were Type IIa. The patients presented with gelastic seizures (15–20 per day), generalized epilepsy, behavioral abnormalities, and alterations of the sleep cycle. Precocious puberty was present in one patient. The Type IIb tumor had a volume of 1.8 cm3, and the Type IIa tumors were 597 mm3 and 530.1 mm3. The lesions received 12.5 Gy, 14 Gy, and 15 Gy, respectively, to the 50% isodose line. The patients were followed for 30 to 50 months. After 3 months, all patients showed improvement of their sleep, behavior, and epilepsy. At the present time, these patients are receiving low-dose antiepileptic agents and have achieved adequate social development and school integration. Conclusions. Gamma knife surgery appears to be a good, safe, and effective option for the treatment of selected hypothalamic hamartomas. No morbidity or mortality was associated with these three cases.

Pubertas praecox in craniopharyngioma

1981 ◽  
Vol 55 (1) ◽  
pp. 127-131 ◽  
Author(s):  
José M. Cabezudo ◽  
Carmelo Perez ◽  
Jesús Vaquero ◽  
Rafael Garcia-De-Sola ◽  
Gonzalo Bravo
Keyword(s):  
Computerized Tomography ◽  
Precocious Puberty ◽  
Hormonal Therapy ◽  
Sexual Maturation ◽  
Residual Tumor ◽  
Hypothalamic Area ◽  
Content Type ◽  
Pubertas Praecox ◽  
Postoperative Course ◽  
Fine Print

✓ A case of craniopharyngioma associated with true precocious puberty is reported in a child operated on when she was 2 years and 8 months of age. Precocity was noted 10 months after operation and was fully documented 1 year later. A pneumoencephalogram showed a recurrence of tumor in the hypothalamic area. Hormonal therapy was instituted to stop sexual maturation. Reoperation was undertaken only when her visual symptoms reappeared. She received a postoperative course of radiotherapy. On last examination, she was neurologically well, and computerized tomography did not show further growth of the residual tumor. The diagnosis of precocious puberty and its etiology in this patient are discussed.

Two fluid-blood density levels in chronic subdural hematoma

1992 ◽  
Vol 77 (2) ◽  
pp. 310-311 ◽  
Author(s):  
Naoya Hashimoto ◽  
Takehiko Sakakibara ◽  
Kazuaki Yamamoto ◽  
Masahito Fujimoto ◽  
Tarumi Yamaki
Keyword(s):  
Computerized Tomography ◽  
Subdural Hematoma ◽  
Chronic Subdural Hematoma ◽  
Content Type ◽  
Blood Density ◽  
Two Fluid ◽  
Tomography Scan ◽  
Fine Print ◽  
Fluid Blood

✓ The case of a chronic subdural hematoma is presented in which the computerized tomography scan showed two parallel fluid-blood density levels. The authors emphasize the importance of this finding in the management of such cases.

Regression of a presumed meningioma with the antiestrogen agent mepitiostane

2000 ◽  
Vol 93 (1) ◽  
pp. 132-135 ◽  
Author(s):  
Shoji Oura ◽  
Takeo Sakurai ◽  
Goro Yoshimura ◽  
Takeshi Tamaki ◽  
Teiji Umemura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Computerized Tomography ◽  
General Condition ◽  
Distal Gastrectomy ◽  
Content Type ◽  
Loss Of Appetite ◽  
Tomography Scan ◽  
Fine Print

✓ This 68-year-old woman underwent a distal gastrectomy for gastric cancer in August 1994. A presumed meningioma of the falx was found incidentally on a staging examination of the gastric cancer, but the meningioma was not treated with surgery. Instead, after gastrectomy the patient received tegafur as adjuvant chemotherapy until February 1996, when she was readmitted to the hospital because of loss of appetite and emaciation but with no recurrence of the gastric cancer. A computerized tomography scan obtained during this second admission showed no change in the meningioma. To improve her general condition, tegafur was discontinued and she was started on a course of the antiestrogen agent mepitiostane. Administration of mepitiostane for approximately 2 years resulted in a marked regression (73%) of the meningioma. This is the first reported case of a presumed meningioma that regressed as a result of use of the antiestrogen agent mepitiostane.

Cerebral histoplasmoma

1983 ◽  
Vol 59 (2) ◽  
pp. 332-336 ◽  
Author(s):  
Saeed T. Vakili ◽  
John N. Eble ◽  
Bruce D. Richmond ◽  
Robert A. Yount
Keyword(s):  
Brain Tumor ◽  
Computerized Tomography ◽  
Occipital Lobe ◽  
Metastatic Brain Tumor ◽  
Content Type ◽  
Recent Onset ◽  
Tomography Scan ◽  
Fine Print

✓ A 55-year-old man presented with dementia and seizures of recent onset. A computerized tomography scan revealed a ring-like lesion in the left occipital lobe, which on resection was found to be a histoplasmoma. Cerebral histoplasmoma is rare and simulates a metastatic brain tumor. Only eight cases of this entity have been reported.

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