Effect of hypertension on small-vessel healing after microvascular anastomosis

1987 ◽  
Vol 67 (5) ◽  
pp. 706-709
Author(s):  
Paul D. Dernbach ◽  
Joel B. Myklebust ◽  
Joseph F. Cusick
Keyword(s):  
Cerebrovascular Disease ◽  
Spontaneously Hypertensive Rats ◽  
Thrombus Formation ◽  
Anastomotic Site ◽  
Microvascular Anastomosis ◽  
Hypertensive Rats ◽  
Content Type ◽  
Spontaneously Hypertensive ◽  
Small Arteries ◽  
Common Carotid Arteries

✓ Artery-to-artery microvascular anastomosis (MVA) has become an established therapeutic alternative for patients with giant intracranial aneurysms and other forms of cerebrovascular disease. Many patients afflicted with cerebrovascular disease also suffer from hypertension. To evaluate the effect of hypertension on healing of small arteries following MVA, 36 spontaneously hypertensive rats were subjected to end-to-side MVA of their common carotid arteries. At specific times after surgery the rats were sacrificed; the anastomotic site was removed and examined with light microscopy and scanning electron microscopy. All MVA's were patent, and there was no evidence of thrombus formation or stenosis at the operative site in any group. Also, there was no difference between the spontaneously hypertensive rats and the control normotensive rat group in the rate of endothelial coverage of the MVA. The presence of hypertension appears to have no effect on healing of small arteries in the rat.

scholarly journals Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137027 ◽  
Author(s):  
Teresa Palao ◽  
Karl Swärd ◽  
Aldo Jongejan ◽  
Perry D. Moerland ◽  
Judith de Vos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Er Stress ◽  
Expression Analysis ◽  
Spontaneously Hypertensive Rats ◽  
Microrna Expression ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Small Arteries

Platelet Thrombus Formation in Microvessels of Young Spontaneously Hypertensive Rats

1998 ◽  
Vol 20 (8) ◽  
pp. 917-937 ◽  
Author(s):  
David Lominadze ◽  
Irving G. Joshua ◽  
James L. Catalfamo ◽  
Dale A. Schuschke
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Thrombus Formation ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Platelet Thrombus

R 68 070, A COMBINED TXA2-SYNTHETASE/TXA2-PROSTAGLANDIN ENDOPEROXIDE RECEPTOR INHIBITOR. REDUCES CEREBRAL INFARCT SIZE AFTER PHOTOCHEMICALLY INITIATED THROMBOSIS IN SPONTANEOUSLY HYPERTENSIVE RATS

1987 ◽  
Author(s):  
J Van Reempts ◽  
B Van Deuren ◽  
M Borqers ◽  
F De Clerck
Keyword(s):  
Infarct Size ◽  
Spontaneously Hypertensive Rats ◽  
Thrombus Formation ◽  
Cerebral Infarct ◽  
Control Group ◽  
Receptor Blockade ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Prostaglandin Endoperoxide ◽  
Physiological Variables

The effects of R 68 070, an oxime-alkane carboxylic acid derivative combining specific thromboxane A2 (TXA2) synthetase inhibition with TXA2/prostaglandin endoperoxide receptor blockade in one molecule, were investigated in a model of photochemically induced stroke in spontaneously hypertensive rats.Each experimental group was compared with an untreated control group. All animals were anesthetized with halothane in N20/02 and artificially ventilated. After incision of the scalp and stereotaxic positioning of a fibre optic light source, halothane was discontinued. When physiological variables reached normal values, a focal cortical infarction was produced by injection of 10 mg.kg-1 rose bengal and 20 min irradiation of the brain through the intact skull. Four hours later the brains were perfusion fixed and damaged areas measured on consecutive histologic sections. Infarct size was calculated by numerical integration.R 68 070 (40 mg.kg-1 p.o.,-3 h) significantly reduced the cerebral infarct size to 2.32 mm3 compared with 5.78 mm3 in controls (median values; n = 5; p < 0.05). At 2.5 mg.kg-1 the lesion was reduced from 11.75 mm3 in the control group to 7.82 mm3 in the treated group (n = 5; p = 0.095). Serum TXB2 levels were reduced by > 80 %.Production of damage in this model is based upon photodynamic generation of singlet molecular oxygen, resulting in peroxidative endothelial cell injury and subsequent platelet thrombus formation. Protection with R 68 070 can be explained by the anti-thrombotic effect of the compound. The relative contribution to this protective effect of synthetase and receptor blockade by R 68 070 are being investigated.

Fermented rice bran extract improves blood pressure and glucose in stroke-prone spontaneously hypertensive rats

2019 ◽  
Vol 49 (5) ◽  
pp. 844-853 ◽  
Author(s):  
Ardiansyah ◽  
Wahyudi David ◽  
Dody Dwi Handoko ◽  
Bram Kusbiantoro ◽  
Slamet Budijanto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Oral Administration ◽  
Rice Bran ◽  
Spontaneously Hypertensive Rats ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Hypertensive Rats ◽  
Content Type ◽  
Spontaneously Hypertensive

PurposeThe purpose of this study was to evaluate thein vitroandin vivoeffects of three varieties of Indonesian fermented rice bran (RB) (Inpari 6, Inpari 30 and Inpara 1).Design/methodology/approachThree types of RB were fermented usingRhizopus oligosporus. The total phenolic content (TPC) was determined using the Folin–Ciocalteau method, and antioxidant activity was analyzed by measuring the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (RSA). Forin vivoanalyses, one week after acclimatization, stroke-prone spontaneously hypertensive rats (n= 4, 12 weeks of age) were divided into two groups and orally administered fermented RB (40 mg/kg body weight) or distilled water as a control after 16 h of fasting. Blood pressure (BP) was measured before and 2, 4 and 6 h after administration with a BP monitor without warming. Six days later, the rats were subject to the same procedure and sacrificed after 6 h of oral administration. Blood was collected and the plasma was separated to measure nitric oxide, glucose and insulin levels.FindingsThe highest TPC and RSA of fermented RB were obtained from Inpari 30 after incubation for 72 h (260.33 ± 0.39 mg GAE/100 g dry basis and 83.71 ± 0.61 per cent), respectively. Furthermore, single oral administration of fermented RB improved BP (p< 0.05) and glucose metabolism after 6 h of administration (p< 0.05).Originality/valueThis is the first study to evaluate the effects of fermented RB on improving high BP and glucose profiles by using a spontaneously hypertensive animal model.

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