scholarly journals Identification of Intraplaque Hemorrhage on MR Angiography Images: A Comparison of Contrast-Enhanced Mask and Time-of-Flight Techniques

2011 ◽  
Vol 32 (3) ◽  
pp. 454-459 ◽  
Author(s):  
Y. Qiao ◽  
M. Etesami ◽  
S. Malhotra ◽  
B.C. Astor ◽  
R. Virmani ◽  
...  
Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Hongge Shu ◽  
Jie Sun ◽  
Niranjan Balu ◽  
Haining Liu ◽  
Daniel S Hippe ◽  
...  

Introduction: Contrast-enhanced MR angiography (CE-MRA) provides highly accurate measurement of carotid stenosis. But non-contrast techniques are desired as contrast agents may lead to anaphylaxis or nephrogenic system fibrosis. Recently, an inversion-recovery gradient echo sequence with phase-sensitive reconstruction was developed for assessment of lumen and intraplaque hemorrhage in one sequence - Simultaneous Noncontrast Angiography and intraPlaque hemorrhage (SNAP). Hypothesis: We tested the hypothesis that SNAP provides an accurate and reproducible assessment of carotid stenosis compared to CE-MRA. Methods: Fifty-eight subjects with 16-79% stenosis on ultrasound were scanned using a large-coverage (16 cm), isotropic-resolution (0.8 mm) SNAP sequence. Minimum intensity projections were generated at ten degrees increments to get 3D views of carotid arteries. Carotid stenosis was measured bilaterally according to the NASCET criteria by independent readers to estimate inter-reader reproducibility. To assess agreement between SNAP and CE-MRA, 24 subjects also underwent CE-MRA with same resolution (0.8 mm isotropic) after injection of gadolinium contrast (Magnevist). Maximum intensity projections were generated for CE-MRA and analyzed while blinded to SNAP data. Results: Of 116 carotid arteries imaged by SNAP, 10 (8.6%) were excluded by at least one reader due to poor image quality or insufficient coverage. Inter-reader reproducibility was high, yielding an intra-class correlation coefficient (ICC) of 0.95 (95% CI: 0.93, 0.96). When stenosis measurements were categorized as no/mild (0-29%), moderate (30-69%) and severe (70-99%), weighted kappa was 0.77 (95% CI: 0.66, 0.88). In the 48 arteries with CE-MRA images, agreement between SNAP and CE-MRA was excellent (ICC: 0.96, 95% CI: 0.92, 0.98; weighted kappa: 0.90, 95% CI: 0.79, 1.00). Conclusions: SNAP can be used to obtain accurate and reproducible measurement of extracranial carotid artery stenosis without gadolinium contrast. The ability of SNAP to assess both traditional (stenosis) and emerging (intraplaque hemorrhage) risk factors may promote its use in clinical workup of carotid stenosis.


2008 ◽  
Vol 29 (8) ◽  
pp. 1530-1536 ◽  
Author(s):  
N. Anzalone ◽  
F. Scomazzoni ◽  
M. Cirillo ◽  
C. Righi ◽  
F. Simionato ◽  
...  

2005 ◽  
Vol 21 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Gordon F. Gibbs ◽  
John Huston ◽  
Matthew A. Bernstein ◽  
Stephen J. Riederer ◽  
Robert D. Brown

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Ivan Platzek ◽  
Dominik Sieron ◽  
Philipp Wiggermann ◽  
Michael Laniado

Purpose. The aim of this study was to assess the correlation of 3D time-of-flight MR angiography (TOF MRA) and contrast-enhanced MR angiography (CEMRA) for carotid artery stenosis evaluation at 3T.Material and Methods. Twenty-three patients (5 f, 18 m; mean age 61 y, age range 45–78 y) with internal carotid artery stenosis detected with ultrasonography were examined on a 3.0T MR system. The MR examination included both 3D TOF MRA and CEMRA of the carotid arteries. MR images were evaluated independently by two board-certified radiologists. Stenosis evaluation was based on a five-point scale. Stenosis grades determined by TOF and CEMRA were compared using Spearman’s rank correlation coefficient and the Wilcoxon test. Cohen’s Kappa was used to evaluate interrater reliability.Results. CEMRA detected stenosis in 24 (52%) of 46 carotids evaluated, while TOF detected stenosis in 27 (59%) of 46 carotids. TOF MRA yielded significantly higher results for stenosis grade in comparison to CEMRA (P=0.014). Interrater agreement was very good for both TOF MRA (κ=0.93) and CEMRA (κ=0.93).Conclusion. At 3T, 3D TOF MRA should not be used as replacement for contrast-enhanced MRA of the carotid arteries, as it results in significantly higher stenosis grades.


2009 ◽  
Vol 31 (5) ◽  
pp. 912-918 ◽  
Author(s):  
T.J. Kaufmann ◽  
J. Huston ◽  
H.J. Cloft ◽  
J. Mandrekar ◽  
L. Gray ◽  
...  

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