Regulation of 10P2 Murine Mast Cell Proliferation and Secretory Function by Stem Cell Factor or IL-9

1998 ◽  
Vol 217 (4) ◽  
pp. 439-444 ◽  
Author(s):  
D. S. Allen-Gipson ◽  
M. Chen ◽  
A. S. Heiman
Keyword(s):  
Cell Proliferation ◽  
Mast Cell ◽  
Stem Cell ◽  
Stem Cell Factor ◽  
Secretory Function ◽  
Murine Mast Cell

scholarly journals Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.

1991 ◽  
Vol 88 (14) ◽  
pp. 6382-6386 ◽  
Author(s):  
M. Tsai ◽  
T. Takeishi ◽  
H. Thompson ◽  
K. E. Langley ◽  
K. M. Zsebo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mast Cell ◽  
Stem Cell ◽  
Stem Cell Factor ◽  
Kit Ligand

Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response

Blood ◽  
1996 ◽  
Vol 87 (9) ◽  
pp. 3655-3668 ◽  
Author(s):  
AM O'Farrell ◽  
M Ichihara ◽  
AL Mui ◽  
A Miyajima
Keyword(s):  
Mast Cell ◽  
Stem Cell ◽  
Mast Cells ◽  
Cell Line ◽  
Stem Cell Factor ◽  
Mapk Pathway ◽  
Interleukin 3 ◽  
Murine Mast Cell ◽  
Mast Cell Line

Stem cell factor (SCF) and interleukin-3 (IL-3) both act on several target hematopoietic populations, including mast cells. We have isolated a unique murine mast cell line, B6M, that is phenotypically similar to immature mast cells. For B6M cells, IL-3 is a survival factor and alone does not stimulate proliferation. SCF can stimulate proliferation of B6M cells, and together IL-3 and SCF synergize to stimulate optimal proliferation and long-term growth. A sustained induction of c-myc is observed only in the presence of SCF (with or without IL-3). In B6M cells, both IL-3 and SCF stimulate phosphorylation of Shc and activation of the Ras, Raf-1, MAPK pathway. Interestingly, IL-3 plus SCF synergistically activate MAPK. IL-3, but not SCF, leads to activation of Jak 2 and Stat 5 and induces pim-1 expression. From these data, we suggest that the induction of pim-1 and c-myc is independently regulated. Furthermore, IL-3-stimulated activation of the Jak 2/Stat 5 pathway, induction of pim-1, and activation of the Ras/MAPK pathway are insufficient to mediate proliferation of B6M cells. The unusual IL-3 response of B6M cells provides a useful model to dissect signals required for IL-3-stimulated survival and proliferation.

Role for the stem cell factor/KIT complex in schwann cell neoplasia and mast cell proliferation associated with neurofibromatosis

1994 ◽  
Vol 37 (3) ◽  
pp. 415-432 ◽  
Author(s):  
J. J. Ryan ◽  
K. A. Klein ◽  
T. J. Neuberger ◽  
J. A. Leftwich ◽  
E. H. Westin ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mast Cell ◽  
Stem Cell ◽  
Schwann Cell ◽  
Stem Cell Factor
Sign in / Sign up

Export Citation Format

Share Document