BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This studywas undertaken to find out the effects of extract from the fruits of medicinal plant Ammi visnaga andseeds of Myristica fragrans (both of which contain documented natural Calcium channel blockers) onvolume and acidity of Carbachol induced gastric section. Their effects were also compared to find outany difference in their effect.DESIGN: Quasi experimental.PLACE & DURATION OF STUDY: Pharmacology Department Saidu Medical College Swat.METHODS: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept onfasting for 48 hours, after which the pylorus of each animal was ligated. Carbachol 600iig/kg wasinjected to group A Extracts of Ammi visnaga and Myristica fragrans 500 mg/kg body weight each andafter 15 minutes Carbachol 600jlg/kg body weight was administered to group B & C intraperitoneally.RESULTS: It was found that both the extracts reduced the volume, free and total acidity of gastricsecretion, which were statistically highly significant when compared with Carbachol ( PcO.OOl). Whenthe differences of means for both the extracts were compared, all these were found statistically nonsignificant indicating that the extracts have similar effects on all parameters included in study.CONCLUSION: The extracts can be used effectively and safely in the treatment of hyper acidityconditions and peptic ulcer after evaluation of their effects in human.KEY WORDS: Ammi visnaga & Myristica fragrans, gastric secretion.
COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT “ AMMI VISNAGA AND MYRISTICA FRAGRANS” ON THE VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION IN FASTING RABBITS.
