scholarly journals COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT “ AMMI VISNAGA AND MYRISTICA FRAGRANS” ON THE VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION IN FASTING RABBITS.

1969 ◽  
Vol 4 (2) ◽  
pp. 533-536
Author(s):  
SHAKIRULLAH JAN ◽  
SUBHANULLAH JAN ◽  
MUHAMMAD JAN ◽  
MASUD UR REHMAN
Keyword(s):  
Body Weight ◽  
Peptic Ulcer ◽  
Medicinal Plant ◽  
Gastric Secretion ◽  
Channel Blockers ◽  
Medical College ◽  
Ammi Visnaga ◽  
Myristica Fragrans ◽  
Group A ◽  
Group B

BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This studywas undertaken to find out the effects of extract from the fruits of medicinal plant Ammi visnaga andseeds of Myristica fragrans (both of which contain documented natural Calcium channel blockers) onvolume and acidity of Carbachol induced gastric section. Their effects were also compared to find outany difference in their effect.DESIGN: Quasi experimental.PLACE & DURATION OF STUDY: Pharmacology Department Saidu Medical College Swat.METHODS: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept onfasting for 48 hours, after which the pylorus of each animal was ligated. Carbachol 600iig/kg wasinjected to group A Extracts of Ammi visnaga and Myristica fragrans 500 mg/kg body weight each andafter 15 minutes Carbachol 600jlg/kg body weight was administered to group B & C intraperitoneally.RESULTS: It was found that both the extracts reduced the volume, free and total acidity of gastricsecretion, which were statistically highly significant when compared with Carbachol ( PcO.OOl). Whenthe differences of means for both the extracts were compared, all these were found statistically nonsignificant indicating that the extracts have similar effects on all parameters included in study.CONCLUSION: The extracts can be used effectively and safely in the treatment of hyper acidityconditions and peptic ulcer after evaluation of their effects in human.KEY WORDS: Ammi visnaga & Myristica fragrans, gastric secretion.

scholarly journals COMPARISON BETWEEN THE EFFECTS OF EXTRACTS FROM THREE MEDICINAL PLANTS “ AMMI VISNAGA, MYRISTICA FRAGRANS AND OLEA EUROPEA” ON STIMULATED GASTRIC SECRETION IN FASTING RABBITS.

1969 ◽  
Vol 5 (1) ◽  
pp. 648-651
Author(s):  
SUBHANULLAH JAN ◽  
SHAKIRULLAH JAN ◽  
MUHAMMAD JAN ◽  
WAJID ALI ◽  
MASUD UR REHMAN
Keyword(s):  
Peptic Ulcer ◽  
Medicinal Plants ◽  
Gastric Secretion ◽  
Channel Blockers ◽  
Local Breed ◽  
Mean Values ◽  
Ammi Visnaga ◽  
Myristica Fragrans ◽  
Group A ◽  
Olea Europea

BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. Thisstudy was undertaken to find out the effects of extract from the fruits of medicinal plants Ammi visnaga,seeds of Myristica fragrans and leaves of Olea europea (all of which contain documented naturalCalcium channel blockers) on volume and acidity of Carbachol induced gastric section. Their effectswere also compared to find out any difference in their efficacy.OBJECTIVE: To find out the comparative effectiveness of three medicinal plants extracts for thetreatment of peptic ulcer and disease associated with hyper gastric acidity conditions.MATERIAL & METHODS: Forty rabbits of local breed, weighing 1-1.5kg were used. The animalswere kept on fasting for 48 hours, divided into group A, B, C & D. pylorus of each animal was ligatedafter a midline incision. Each extracts 500 mg/kg body weight and Carbachol 600pg/kg body weightwere administered in traperitoneally.RESULTS: It was found that all the extracts reduced the volume, free and total acidity of gastricsecretion, which were statistically highly significant when compared with Carbachol (PcO.OOl). Byobserving the mean values of all the extracts, it was clear that Ammi visnaga was more effective thanMyristica fragrans which was in turn more effective than Olea europea on all parameters included instudy.CONCLUSION: The three extracts therefore, can be used effectively in the treatment of peptic ulcerand all other diseases associated with hyper gastric acidity.KEY WORDS: Extracts & gastric secretion

scholarly journals COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT “ AMMI VISNAGA AND CIMETIDINE ON THE VOLUME AND ACIDITY OF STIMULATED GASTRIC SECRETION IN FASTING RABBITS.

1969 ◽  
Vol 2 (2) ◽  
pp. 165-168
Author(s):  
Muhammad Jan
Keyword(s):  
Myocardial Infarction ◽  
Body Weight ◽  
Medicinal Plant ◽  
Gastric Secretion ◽  
Channel Blocker ◽  
Channel Blockers ◽  
Total Acidity ◽  
Local Breed ◽  
Ammi Visnaga ◽  
The Difference

Background: Peptic ulcer is mostly produced due to the over production of gastric acid. This study wasundertaken to find out the effects of extract from medicinal plant “ Ammi visnaga” (which containsdocumented natural Calcium channel blocker) and Cimetidine on volume and acidity of Carbachol inducedgastric section. Their effects were also compared to find out any difference in their efficacy.METHODS: Thirty rabbits of local breed, weighing 1-1 ,5kg were used. The animals were kept on fastingfor 48 hours, after which the pylorus of each animal was ligated. Cimetidine 2.5 mg/kg, Ammi visnaga, 500mg/kg and Carbachol 600g/kg body weight were administered intraperitoneally.Results: It was found that Cimetidine reduced the volume, free and total acidity of gastric secretion, whichwere highly significant when compared with Carbachol ( P<0.001). The extract also had the same effects.When the difference of mean for Cimetidine was compared with that of extract, all these differences werefound non-significant indicating that the extract has similar effect as that of Cimetidine on all parametersincluded in the study.Conclusion: The extract from the fruits of Ammi visnaga therefore, be used effectively in the treatment ofpeptic ulcer and all other conditions like angina, myocardial infarction and hypertension which requirecalcium channel blockers for their treatment.Key words: Ammi visnaga, Zollinger-Ellison (Z.E) syndrome

scholarly journals Kala-azar in Children: A Retrospective Study

1970 ◽  
Vol 17 (2) ◽  
pp. 99-103
Author(s):  
MI Bari ◽  
MQK Talukdar ◽  
FH Nazir ◽  
AB Siddiqui ◽  
MH Haidary
Keyword(s):  
Body Weight ◽  
Sodium Stibogluconate ◽  
Cure Rate ◽  
College Hospital ◽  
Medical College ◽  
Kala Azar ◽  
Group A ◽  
Group B ◽  
Discharge From Hospital ◽  
Cure Rates

Fifty children with Kala-azar {27 male (54%) and 23 female (46%)} aged between 2-12 yrs, were studied retrospectively in the pediatric unit of Rajshahi Medical College Hospital to find out the optimal treatment of Kala-azar in children. Sodium stibogluconate was given intravenously at a dose of 10 mg/kbw/day for 20 days in one group (Group-A), 15 mg/kbw/day for 20 days in another group (Group-B), 10 mg/kbw/day B.D. for 20 days in another group (Group-C), and 20 mg/kg of body wt/day for 40 days is last group (Group-D). The apparent cure rates of all regimens were 100%. Side effects of sodium stibogluconate were mild, however, myocarditis developed on 37th day of treatment in one patient which reversed to normal after discontinuation of the drug. 27 patients (54%) could be followed up to six months after discharge from hospital. Two patients in group-A relapsed and none relapsed from group B, C or D. Follow-up of patients in group B, C and D showed improvement in general condition, increase in body weight, Hb% and regression of the size of the liver and spleen and ultimate rate of cure in B, C, D regimens were 100%. But ultimate cure rate in-group A was 71.4% and the significance of difference between A and other regimens (P<0.10) were statistically significant. Sodium stibogluconate 15mg/kg body weight once daily for 20 days (Group-B) had the best of cure rate with low toxicity and may be recommended for routine treatment of childhood Kala-azar in this country.   doi: 10.3329/taj.v17i2.3455   TAJ 2004; 17(2): 99-103

scholarly journals COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT OLEA EUROPEA AND VERAPAMIL ON STIMULATED GASTRIC SECRETION IN FASTING RABBITS

1969 ◽  
Vol 1 (1) ◽  
pp. 12-15
Author(s):  
Muhammad Jan ◽  
Hidayatur-Rahman ◽  
Alamzeb ◽  
Shafiq Tariq ◽  
Masood-ur- Rehman
Keyword(s):  
Peptic Ulcer ◽  
Medicinal Plant ◽  
Gastric Secretion ◽  
Calcium Channel ◽  
Channel Blocker ◽  
Channel Blockers ◽  
Local Breed ◽  
Hypertension Prevention ◽  
Olea Europea ◽  
The Difference

Background: Peptic ulcer is mostly produced due to the over production of gastric acid. This study wasdesigned to find out the effects of extract from the leaves of medicinal plant Olea europea (which containsdocumented natural Calcium channel blocker) and Verapamil on volume and acidity of Carbachol inducedgastric section. Their effects were also compared to find out any difference in their efficacy.Methods: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept fasting for 48hours, after which the pylorus of each animal was ligated. Verapamil 10 mg/kg, Olea europea 500 mg/kg andCarbachol 600 g/kg body weight were administered intraperitoneally.Results : It was found that Verapamil reduced the volume, free and total acidity of gastric secretion, whichwere statistically highly significant when compared with Carbachol (P<0.001). The extract also had thesame effects, when the difference of mean for Verapamil was compared with that of extract, all thesedifferences were found statistically significant(p<0.05) indicating that the extract has less effect ascompared to Verapamil on all parameters included in the study.Conclusion: The extract from the leavesof Olea europea therefore, may be used effectively in the treatmentof peptic ulcer and all other conditions like angina, myocardial infarction, hypertension, prevention ofpremature labor and bronchial asthma which require calcium channel blockers for the treatment of thesedisorders.

COMPARATIVE EFFECTS OF PLANT EXTRACT ON GASTRIC SECRETION

1969 ◽  
Vol 3 (2) ◽  
pp. 331-334
Author(s):  
MUHAMMAD JAN ◽  
RAHMAN SHAH
Keyword(s):  
Gastric Secretion ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Juice ◽  
Total Acidity ◽  
Medical College ◽  
Ammi Visnaga ◽  
Group A ◽  
Olea Europea ◽  
Titration Data

OBJECTIVE: To compare the effects of extracts from medicinal plantsAmmi Visnaga & Olea eurpea onVolume and acidity of stimulated gastric secretion in rabbits.METHODS: The present study was carried out in department ofPharmacology & therapeutics, Saidu Medical College Swat Pakistan between July 2008 to June 2009.Thirty rabbits weighing 1-1 ,5kg were included. They were divided in to groups A, B &C each having 10animals. After fasting for 48 hours, pylorus of each animal was ligated. To group A Carbachol, group Bextracts of Ammi visnaga and group C Olea europea followed by Carbachol after 15 minutes to groups B &C were administered intraperitoneally. After 4 hours, stomach was removed, volume was measured,contents centrifuged & estimation for acidity was done by method of titration. Data was subjected tostatistical analysis.RESULTS: In groups B & C, reduction in volume, free and total acidity of gastric juice was observed. Allthese reductions were found statistically highly significant when their means were compared with that ofgroupA(P <0.001).CONCLUSION: Extracts can be used effectively in the treatment of hyper acidity conditions and pepticulcer after evaluation of their effects in human being.KEYWORDS: Ammi Visnaga, Olea Europea, gastric acid secretion.

scholarly journals COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT“OLEA EUROPEA” AND MYRISTICA FRAGRANS ON THE VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION IN FASTING RABBITS.

1969 ◽  
Vol 4 (1) ◽  
pp. 446-449
Author(s):  
MUHAMMAD JAN ◽  
RAHMAN SHAH
Keyword(s):  
Body Weight ◽  
Peptic Ulcer ◽  
Gastric Secretion ◽  
Channel Blocker ◽  
Total Acidity ◽  
Local Breed ◽  
Mean Values ◽  
Myristica Fragrans ◽  
Olea Europea ◽  
The Mean

BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This studywas undertaken to find out the effects of extracts from medicinal plants Olea europea and Myristicafragrans (Both of them contains documented natural Calcium channel blocker) on volume and acidity ofCarbachol induced gastric section.METHODS: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept onfasting for 48 hours. After general anesthesia, pylorus of each animal was ligated. Both the extracts 500mg/kg each and Carbachol 600| ig/kg body weight after 15 minutes were administered intraperitoneally.RESULTS : When the means of all the parameters were compared with that of carbachol, it was foundthat the extracts reduced the volume, free and total acidity of gastric secretion which were statisticallyhighly significant (P<0.001). When we compared the mean values of volume, free and total acidity forthe two extracts, it was observed that these differences in all the three parameters between groups B andC were found to be non-significant (P>0.5).CONCLUSION: The extracts can be used effectively and safely in the treatment of hyper acidityconditions and peptic ulcer after evaluation its effects in human being.KEY WORDS: Olea europea, Myristica fragrans & gastric secretion.

Comparative Study Between Clean Intermittent Self-Catheterization (Cisc) and Continuous Indwelling Catheterization (Cidc) in Relieving Acute Refractory Retention of Urine Due to Benign Enlargement of Prostate (Bep)

2020 ◽  
Vol 21 (2) ◽  
pp. 105-110
Author(s):  
Md Shawkat Alam ◽  
Sudip Das Gupta ◽  
Hadi Zia Uddin Ahmed ◽  
Md Saruar Alam ◽  
Sharif Muhammod Wasimuddin
Keyword(s):  
Comparative Study ◽  
Acute Urinary Retention ◽  
Bladder Capacity ◽  
Inclusion Criteria ◽  
College Hospital ◽  
Medical College ◽  
High Incidence ◽  
Group A ◽  
Group B ◽  
Better Than

Objective: To compare the clean intermittent self-catheterization (CISC) with continuous indwelling catheterization (CIDC) in relieving acute urinary retention (AUR) due to benign enlargement of prostate (BEP). Materials and Methods :A total 60 patients attending in urology department of Dhaka Medical college hospital were included according to inclusion criteria ,Patients were randomized by lottery into two groups namely group –A and group –B for CISC and IDC drainage respectively . Thus total 60 patients 30 in each group completed study. Results : Most men can safely be managed as out-patients after AUR due to BPH. The degree of mucosal congestion and inflammation within the bladder was found to be lower in those using CISC and the bladder capacity in these patients was also found higher.Patients with an IDC had a high incidence of UTIs then that of patients with CISC. During the period of catheterization the incidence of UTI was 43.3% in group B in comparison to 40% in group A; before TURP 36% in group B in comparison to 10% incidence in group A.According to patient’s opinion CISC is better than IDC in the management of AUR. Experiencing bladder spasm, reporting blood in urine, management difficulties, incidence and severity of pain were less in CISC group, and the method of CISC was well accepted by patients as well as their family members. Conclusion: From the current study it may be suggested that CISC is better technique for management of AUR patient due to BPH than IDC. It can also be very helpful when surgery must be delayed or avoided due to any reasons in this group of patients. Bangladesh Journal of Urology, Vol. 21, No. 2, July 2018 p.105-110

Age related volume of cadaver-prostates in Bangladesh

1970 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Rukshana Ahmed ◽  
Shamim Ara
Keyword(s):  
Prostate Gland ◽  
Age Groups ◽  
Clinical Settings ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Key Words Prostate ◽  
The Mean ◽  
Group B

Pathological changes in the prostate gland occur commonly with advancing age including inflammation, atrophy, hyperplasia and carcinoma and a change in volume is also evident. Estimation of volume of prostate may be useful in a variety of clinical settings. A cross-sectional descriptive study was designed to see the changes in volume of the prostate with advancing age and done in the Department of Anatomy, Dhaka Medical College, Dhaka from August 2006 to June 2007. The study was performed on 70 post-mortem human prostates collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age groups; group A (10-20 years), group B (21-40 years) and group C (41-70 years). Volume of the sample was measured by using the ellipsoid formula. The mean ± SD volume of prostate was 7.68 ± 3.64 cm3 in group A, 10.61 ± 3.99 cm3 in group B and 15.40 ± 6.31 cm3 in group C. Mean difference in volume between group A and group C, group B and group C were statistically significant (p<0.001). Statistically significant positive correlation was found between age and volume of prostate (r = + 0.579, p < 0.001). Key Words: Prostate; volume; Bangladeshi. DOI: 10.3329/imcj.v4i2.6501Ibrahim Med. Coll. J. 2010; 4(2): 74-77

scholarly journals Comparative study between two empirical antibiotic regime in the management of childhood malignancy with fever

2015 ◽  
Vol 5 (2) ◽  
pp. 329-331 ◽  
Author(s):  
Laila Helaly ◽  
Md Zakir Hossain Sarker ◽  
MA Mannan ◽  
Md Tafazzal Hossain ◽  
Shafi Ahmed ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Study Drug ◽  
Successful Outcome ◽  
Medical College ◽  
Pediatric Hematology ◽  
Pediatric Cancer Patients ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
Oncology Unit

Objective : The present prospective randomized clinical trial was carried out to assess whether combined cefepime and amikacin as empirical antibiotic therapy was more effective than combined ceftriaxone and gentamicin in the treatment of febrile neutropenic children with malignant diseases.Material & Methods : The study was conducted in the Pediatric Hematology and Oncology unit of BSMMU over a period of 2 years. (From January 2006 to December 2007) Hospitalised pediatric cancer patients who developed febrile neutropenia following chemotherapy or radiotherapy were the study population. A total 64 cases were consecutively included in the study and were randomly assigned to either cefepime & amikacin group (Group- A) or ceftriaxone & gentamicin group (Group-B). The Group-A received cefepime 1500 mg/m2/dose infused over 15 minutes in two divided doses intravenously(IV) while amikacin was administered as thrice daily dose of 200 mg/m2/dose. Patients of Group-B received ceftriaxone 1500 mg/m2/dose in two divided doses and gentamicin 60 mg/m2/dose thrice daily IV. The therapy was continued until absolute neutrophil counts reached >1000 neutrophils/mm3. The treatment outcome was considered successful if fever resolves within 4 days and does not recur within 7 days of completion of therapy. Of the 64 patients, 13 cases were excluded from the final analysis.Results : Bacteria were isolated from culture in only 16.7% of cases Group-A and 9.5% of group-B. Patients E. coli was the most common isolate found in blood specimen (37%). Following intervention, 90% of cefepime & amikacin group and 85.6% of ceftriaxone & gentamicin group improved absolute neutrophil count to >1000/mm3 of blood. Persistence of fever after start of study drug and duration of antibiotic therapy were significantly less in the former group than those in later group (p = 0.049 and p = 0.004 respectively). Only 1 patient of group B had recurrence of infection within 7 days of treatment completion. The mean duration of hospital stay was less in the former group (7.97 ± 2.61 days) than that in the latter group (11.00 ± 3.42 days) (p = 0.06). Evaluation of final outcome shows that majority (86.6%) of cefepime & amikacin group had successful outcome, while majority of ceftriaxone & gentamicin group (81%) failed to resolve infection with continuation of fever for > 4 days.Conclusion : The study concluded that combined cefepime and amikacin is a better option for empirical treatment of fever and neutropenia in children with malignancies than combined ceftriaxone and gentamicin (p<0.001).Northern International Medical College Journal Vol.5(2) 2014: 329-331

scholarly journals Monopolar Diathermy Tonsillectomy Versus Dissection Method Tonsillectomy

KYAMC Journal ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 21-24
Author(s):  
Md Abdus Salam ◽  
Md Mahbub Alam ◽  
Rezwan Ahmed ◽  
Md Sultan Mahmud
Keyword(s):  
Postoperative Pain ◽  
Postoperative Bleeding ◽  
Throat Pain ◽  
Medical College ◽  
Advantages And Disadvantages ◽  
Case Surgery ◽  
Group A ◽  
The Difference ◽  
Group B ◽  
Dissection Method

Background: Tonsillectomy is one of the most common surgical procedures performed worldwide by otorhinolaryngologists for different indications. Tonsillectomy is often performed as day-case surgery, which increases the demands of a satisfactory postoperative pain control and a low risk of early postoperative bleeding. Objective: The aim of the study was to compare the Monopolar diathermy and Dissection methods of tonsillectomy and evaluate their advantages and disadvantages during surgery, convalescence. Materials and Methods: Two hundred children were recruited for this study during the period of five years from January, 2014 to December, 2018 at Otolaryngology department of Khwaja Yunus Ali Medical College and Hospital (KYAMCH). Subjects between the age of 5 and 25 years listed for tonsillectomy were included. Subjects were recommended not to have aspirin within the 2 weeks before surgery. Results: The mean duration of operation was found 10.6±0.4 minutes in group A and 17.0±0.7 minutes in group B. The difference was statistically significant (p<0.05) between two groups. At 1st day, 11(11.0%) patients had throat pain in group A and 23(23.0%) in group B. At 2nd day, 14(14.0%) patients had throat pain in group A and 25(25.0%) in group B. Which were statistically significant (p<0.05) between two groups. Conclusion: The monopolar diathermy tonsillectomy appears to cause less bleeding, postoperative pain and less time consuming in compare with the dissection tonsillectomy although patients experience slightly more pain than dissection Method. KYAMC Journal Vol. 10, No.-1, April 2019, Page 21-24

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