Oxyphencyclimine for peptic ulcer patients?

1964 ◽  
Vol 2 (21) ◽  
pp. 83-84
Keyword(s):  
Peptic Ulcer ◽  
Side Effects ◽  
Gastric Secretion ◽  
Digestive Tract ◽  
Duodenal Ulceration ◽  
Anticholinergic Drugs ◽  
Prolonged Action ◽  
Selective Action ◽  
Different Parts ◽  
Cholinergic Effects

Many antispasmodic and anticholinergic drugs have been shown to reduce motility and secretion in different parts of the digestive tract, but in doses large enough to be effective these drugs invariably produce side effects. Oxyphencyclimine (Daricon - Pfizer) inhibits gastric secretion in animals without the peripheral anti-cholinergic effects seen with comparably effective gastric anti-secretory doses of other anticholinergic drugs tested. 1 Studies in man suggest that oxyphencyclimine has a selective action on the stomach, 2 that it can relieve symptoms of duodenal ulceration, 3 and that it has a prolonged action.

Inhibition of Basal and Postprandial Gastric Secretion by Poldine and Atropine in Patients with Peptic Ulcer

1962 ◽  
Vol 43 (4) ◽  
pp. 400-406 ◽  
Author(s):  
Robert D. Mitchell ◽  
J.N. Hunt ◽  
Morton I. Grossman
Keyword(s):  
Peptic Ulcer ◽  
Gastric Secretion

scholarly journals Distribution of cesium-137 in reindeer

Rangifer ◽  
1990 ◽  
Vol 10 (2) ◽  
pp. 57 ◽  
Author(s):  
Kristina Rissanen ◽  
Tua Rahola ◽  
Pauli Aro
Keyword(s):  
Digestive Tract ◽  
Chernobyl Accident ◽  
Small Area ◽  
Reindeer Herding ◽  
Nuclear Bomb ◽  
Cesium 137 ◽  
Edible Tissues ◽  
The 1960S ◽  
Meat Samples ◽  
Different Parts

The influence of the Chernobyl accident in 1986 on the Finnish reindeer herding area was much smaller than the effects of the nuclear bomb tests in the 1960s. Only in one small area somewhat more Cs-137 was deposited than in the rest of the reindeer herding area. From that area 20 reindeer were chosen for investigation of the distribution of Cs-137. All tissues, organs, the skeleton, digestive tract, hide, head and hooves were sampled quantitatively. Three reindeer were pregnant and also the foetuses were studied. The Cs-137 amounts were determined by gammaspectrometric measurements. The results showed that the differences in the Cs-137 concentrations between muscle tissue from different parts of an individual reindeer were not more than 10 percent. Thus it is not essential from which part of the reindeer meat samples for surveillance purposes are taken. The concentration of Cs-137 in edible tissues other than muscle was lower except in the kidneys and scapula cartilage.

scholarly journals Peran Kurkumin Sebagai Terapi Pada Osteoartritis

2020 ◽  
Vol 2 (1) ◽  
pp. 106-110
Author(s):  
Rilianda Abelira
Keyword(s):  
Peptic Ulcer ◽  
Side Effects ◽  
Old Age ◽  
Cyclooxygenase 2 ◽  
Tnf Α ◽  
The World ◽  
Inflammatory Drugs ◽  
Digestive Disorders ◽  
Cox 2 ◽  
Anti Inflammatory

Osteoartritis (OA) merupakan salah satu penyakit penyakit degeneratif atau geriatri yang disebabkan adanya inflamasi yang melibatkan kartilago, lapisan sendi, ligamen, dan tulang yang akibatnya dapat menyebabkan nyeri dan kekakuan pada sendi. Epidemiologi OA di didunia sekitar 15% dengan usia diatas 65-75 dan diperkirakan pada tahun 2020 penderita osteoarthritis akan meningkat 11,6 juta penderita. Kejadian OA di Indonesia dari tahun 1990 hingga 2010 telah mengalami peningkatan sebanyak 44,2% dan berdasarkan usia di Indonesia cukup tinggi dengan 65% pada usia tua (lansia) atau lebih dari 61 tahun. Pengobatan secara farmakologis untuk OA dengan menggunakan Obat Anti Inflamasi Non-Steroid (OAINS) salah satu contohnya adalah meloksikam. Namun, efek samping penggunaan OAINS dapat menimbulkan beberapa masalah seperti timbulnya ulkus peptikum dan gangguan pencernaan. Hal ini menyebabkan sedang dikembangkannya pengobatan herbal untuk OA yang harapannya dapat menjadi pengobatan utama dalam mengatasi OA dengan menggunakan kurkumin. Kurkumin berperan sebagai antiinflamasi dalam kunyit putih dengan menurunkan aktivitas cyclooxygenase 2(COX-2), lipoxygenase dan menghambat produksi sitokin seperti TNF-α, interleukin (IL). Osteoarthritis (OA) is a degenerative or geriatric disease that is caused by inflammation involving cartilages, joint lining, ligaments, and bones which can cause pain and stiffness in the joints. Epidemiology of OA in the world around 15% with ages above 65-75 and it is estimated in 2020, osteoarthritis will increase by 11.6 million. The incidence of OA in Indonesia from 1990 to 2010 has increased by 44.2% and by age in Indonesia is quite high with 65% in old age (elderly) or more than 61 years. Treatment for OA is using non-steroidal anti-inflammatory drugs (NSAIDs), such as meloxicam. However, side effects of NSAID use can cause several problems such as the emergence of peptic ulcer and digestive disorders. This has led to the development of herbal treatments for OA which hopes to become the main treatment in overcoming OA by using curcumin. Curcumin acts as an anti-inflammatory in white turmeric by reducing the activity of cyclooxygenase 2 (COX-2), lipoxygenase and inhibiting the production of cytokines such as TNF-α, interleukin (IL).

scholarly journals COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT “ AMMI VISNAGA AND MYRISTICA FRAGRANS” ON THE VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION IN FASTING RABBITS.

1969 ◽  
Vol 4 (2) ◽  
pp. 533-536
Author(s):  
SHAKIRULLAH JAN ◽  
SUBHANULLAH JAN ◽  
MUHAMMAD JAN ◽  
MASUD UR REHMAN
Keyword(s):  
Body Weight ◽  
Peptic Ulcer ◽  
Medicinal Plant ◽  
Gastric Secretion ◽  
Channel Blockers ◽  
Medical College ◽  
Ammi Visnaga ◽  
Myristica Fragrans ◽  
Group A ◽  
Group B

BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This studywas undertaken to find out the effects of extract from the fruits of medicinal plant Ammi visnaga andseeds of Myristica fragrans (both of which contain documented natural Calcium channel blockers) onvolume and acidity of Carbachol induced gastric section. Their effects were also compared to find outany difference in their effect.DESIGN: Quasi experimental.PLACE & DURATION OF STUDY: Pharmacology Department Saidu Medical College Swat.METHODS: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept onfasting for 48 hours, after which the pylorus of each animal was ligated. Carbachol 600iig/kg wasinjected to group A Extracts of Ammi visnaga and Myristica fragrans 500 mg/kg body weight each andafter 15 minutes Carbachol 600jlg/kg body weight was administered to group B & C intraperitoneally.RESULTS: It was found that both the extracts reduced the volume, free and total acidity of gastricsecretion, which were statistically highly significant when compared with Carbachol ( PcO.OOl). Whenthe differences of means for both the extracts were compared, all these were found statistically nonsignificant indicating that the extracts have similar effects on all parameters included in study.CONCLUSION: The extracts can be used effectively and safely in the treatment of hyper acidityconditions and peptic ulcer after evaluation of their effects in human.KEY WORDS: Ammi visnaga & Myristica fragrans, gastric secretion.

scholarly journals On the ability of calves to digest hay

1960 ◽  
Vol 32 (1) ◽  
pp. 161-168
Author(s):  
Aarne Mäkelä
Keyword(s):  
Organic Matter ◽  
Digestive Tract ◽  
Red Clover ◽  
Early Flowering ◽  
Flowering Stage ◽  
Different Parts

Three experiments have been carried out with altogether 16 Ayrshire calves in order to determine the digestibility of timothy hay cured at the early flowering stage and containing some red clover. The ages of the calves varied from 2 ½ to 9 months. Hay was given either totally or almost ad lib. Lignin was used as tracer. In experiment 1 the ages of the six experimental calves varied from 3 to 9 months. The calves aged 5—9 months digested hay equally efficiently when com-pared with each other. The youngest calf aged 3 months digested hay less efficiently (Table 1). In Experiment 2 the ages of the six experimental calves varied from 10 to 22 weeks. In the trial two control cows were also included. The calves aged 10—12 weeks digested hay less efficiently and the calves aged 4—5 months almost as efficiently as the control cows (Table 2). The ability of calves of the same age to digest hay was quite variable. Experiment 3 was carried out with four 7 months old calves. At the end of the trial the calves were slaughtered and the contents of the different parts of the digestive tract were weighed and sampled. On the ground of the analyses of the hay, the contents of the abomasum and the faeces, the digestibilities of N-free organic matter and N-free non-lignin organic matter in the proventriculi and in the whole digestive tract were esimated. The share of the proventriculi in the total digestibility of the said substances was 82—88 per cent (Table 3). The contents of the reticulo-rumen of the calves in Experiment 3 as well as those of younger calves aged 3 ½—4 months were weighed in connection with the slaughtering. The quantity of the contents in calves of 7 months was 30—40 kg and that in calves aged 3 ½—4 months 12—15 kg.

Biperiden and Piroheptine Do Not Affect the Serum Level of Zotepine, a New Antipsychotic Drug

1990 ◽  
Vol 157 (1) ◽  
pp. 128-130 ◽  
Author(s):  
K. Otani ◽  
T. Hirano ◽  
T. Kondo ◽  
S. Kaneko ◽  
Y. Fukushima ◽  
...  
Keyword(s):  
Side Effects ◽  
Serum Level ◽  
Antipsychotic Drug ◽  
Mentally Retarded ◽  
Anticholinergic Drugs

The effects of biperiden and piroheptine on the serum level of zotepine were studied in 15 schizophrenic and 6 mentally retarded in-patients. Neither of these anticholinergic drugs affected the serum level of zotepine nor caused significant side-effects. In the schizophrenics the total scores on the BPRS did not change significantly with either combination of drugs.

Comparison of the Effects of Inhaled SCH 1000 and Fenoterol on Exercise-Induced Bronchospasm in Children

PEDIATRICS ◽  
1980 ◽  
Vol 66 (1) ◽  
pp. 109-114
Author(s):  
R. Yeung ◽  
G. M. Nolan ◽  
H. Levison
Keyword(s):  
Side Effects ◽  
Pulmonary Function ◽  
Controlled Study ◽  
Anticholinergic Drugs ◽  
Base Line ◽  
Anticholinergic Agent ◽  
Asthmatic Children ◽  
Before And After ◽  
Exercise Induced ◽  
Better Than

The effect of 40 µg of SCH 1000 (ipratropium bromide, an anticholinergic agent) on bronchodilation and suppression of exercise-induced bronchospasm (EIB) was compared with 400 µg of fenoterol and a placebo in a single-blind controlled study. Twenty-seven randomly selected asthmatic children performed a standardized treadmill exercise challenge and the 17 children who were shown to have EIB continued in the study. Pulmonary function was evaluated before and after drug administration and exercise. When individual results were analyzed and grouped according to the responsiveness of EIB to the drugs, two patterns emerged: (1) the EIB was more severe in those (6/17) children who did not respond to either drug than in the rest of the children; (2) the resting pulmonary function was significantly better in the children (4/17) who responded to both drugs than in those (7/17) who responded to fenoterol alone. In conclusion SCH 1000 was shown to be an effective bronchodilator comparable to, but no better than, fenoterol. It had minimal side effects. As an EIB inhibitor it depended on relatively normal base line pulmonary function and only a moderate deterioration following exercise, whereas fenoterol depended on the exercise response alone. Although anticholinergic drugs are not very extensively used, SCH 1000 may be useful in some patients where the β2 adrenergic drugs cause significant side effects or are contraindicated.

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