Formulation of probiotics loaded granules of 5-Amino salicylic acid for colon targeting drug delivery system

2021 ◽  
Vol Volume 16 ◽  
pp. 7035-7050
Author(s):  
Bullo Saifullah ◽  
Palanisamy Arulselvan ◽  
Mohamed E El Zowalaty ◽  
Woan Sean Tan ◽  
Sharida Fakurazi ◽  
...  

2016 ◽  
Vol 87 ◽  
pp. 75-79 ◽  
Author(s):  
Kalidhindi Rama Satyanarayana Raju ◽  
Nilesh S. Ambhore ◽  
Shashank Mulukutla ◽  
Saurabh Gupta ◽  
Vishakantha Murthy ◽  
...  

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (12) ◽  
pp. 78-82
Author(s):  
N Jain ◽  
◽  
M. L. Kori

The aim of present study is to improve solubility profile of a poorly soluble anti-cancer natural product, plumbagin at colonic site through incorporation of β-cyclodextrin by preparing complexes by a number of methods. Natural compound plumbagin have lower solubility profile in various GIT medias i.e. 0.1 N HCl, at stomach and intestinal pH. Natural compound plumbagin containing β-cyclodextrin complexes prepared with a number of methods increased the solubility profile in different dissolution media. The nature of plumbagin complexes was ascertained by FTIR spectrum. The tablet formulation of plumbagin β-cyclodextrin complex (kneading method) was prepared and coated with pH sensitive polymer Eudragit L100 for colon targeting. Plumbagin β-cyclodextrin complex can be used in place of pure plumbagin for the preparation of colon targeted drug delivery system.


Sign in / Sign up

Export Citation Format

Share Document