Optimization of Vi Capsular Polysaccharide (Typhoid) Conjugation with Carrier Protein and Characterization of Vi Capsular Polysaccharide Conjugate

2021 ◽  
Vol 13 (02) ◽  
Keyword(s):  
Capsular Polysaccharide ◽  
Carrier Protein ◽  
Vi Capsular Polysaccharide

scholarly journals Laboratory and preliminary clinical characterization of Vi capsular polysaccharide-protein conjugate vaccines.

1994 ◽  
Vol 62 (10) ◽  
pp. 4440-4444 ◽  
Author(s):  
S C Szu ◽  
D N Taylor ◽  
A C Trofa ◽  
J D Clements ◽  
J Shiloach ◽  
...  
Keyword(s):  
Capsular Polysaccharide ◽  
Conjugate Vaccines ◽  
Protein Conjugate ◽  
Vi Capsular Polysaccharide

scholarly journals Rotavirus spike protein ΔVP8* as a novel carrier protein for conjugate vaccine platform with demonstrated antigenic potential for use as bivalent vaccine

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wook-Jin Park ◽  
Yeon-Kyung Yoon ◽  
Ji-Sun Park ◽  
Ruchirkumar Pansuriya ◽  
Yeong-Jae Seok ◽  
...  
Keyword(s):  
Immune Responses ◽  
Conjugate Vaccine ◽  
Capsular Polysaccharide ◽  
Spike Protein ◽  
Carrier Protein ◽  
Vaccine Platform ◽  
Bivalent Vaccine ◽  
Polysaccharide Antigens ◽  
Vi Capsular Polysaccharide ◽  
Functional Antibodies

AbstractConjugate vaccine platform is a promising strategy to overcome the poor immunogenicity of bacterial polysaccharide antigens in infants and children. A carrier protein in conjugate vaccines works not only as an immune stimulator to polysaccharide, but also as an immunogen; with the latter generally not considered as a measured outcome in real world. Here, we probed the potential of a conjugate vaccine platform to induce enhanced immunogenicity of a truncated rotavirus spike protein ΔVP8*. ΔVP8* was covalently conjugated to Vi capsular polysaccharide (Vi) of Salmonella Typhi to develop a bivalent vaccine, termed Vi-ΔVP8*. Our results demonstrated that the Vi-ΔVP8* vaccine can induce specific immune responses against both antigens in immunized mice. The conjugate vaccine elicits high antibody titers and functional antibodies against S. Typhi and Rotavirus (RV) when compared to immunization with a single antigen. Together, these results indicate that Vi-ΔVP8* is a potent and immunogenic vaccine candidate, thus strengthening the potential of conjugate vaccine platform with enhanced immune responses to carrier protein, including ΔVP8*.

Anodic stripping voltammetry of anti-Vi antibody functionalized CdTe quantum dots for the specific monitoring of Salmonella enterica serovar Typhi

RSC Advances ◽  
2015 ◽  
Vol 5 (107) ◽  
pp. 88234-88240 ◽  
Author(s):  
Satish K. Pandey ◽  
Praveen Rishi ◽  
C. Raman Suri ◽  
Aaydha C. Vinayaka
Keyword(s):  
Quantum Dots ◽  
Capsular Polysaccharide ◽  
Anodic Stripping Voltammetry ◽  
Stripping Voltammetry ◽  
Cdte Quantum Dots ◽  
Salmonella Enterica Serovar Typhi ◽  
Novel Approach ◽  
Anodic Stripping ◽  
Vi Capsular Polysaccharide ◽  
Insight Into

CdTe QD based stripping voltammetry for Vi capsular polysaccharide detection. The technique has provided an insight into the competence of CdTe QD and GNP immuno-conjugates. This is a novel approach to characterize the efficiency of immuno-conjugates of QDs and GNPs.

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