scholarly journals Effect of elevated intraocular pressure on the thickness changes of cat laminar and prelaminar tissue using optical coherence tomography

2014 ◽  
Vol 24 (6) ◽  
pp. 2349-2360 ◽  
Author(s):  
Qiuyun Zhao ◽  
Xiuqing Qian ◽  
Lin Li ◽  
Weijian Sun ◽  
Shan Huang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Optical Coherence ◽  
Elevated Intraocular Pressure

scholarly journals Corneal Optical Coherence Tomography Speckle in Crosslinked and Untreated Rabbit Eyes in Response to Elevated Intraocular Pressure

2021 ◽  
Vol 10 (5) ◽  
pp. 2
Author(s):  
Monika E. Danielewska ◽  
Agnieszka Antonczyk ◽  
Danilo Andrade De Jesus ◽  
Maja M. Rogala ◽  
Anna Blonska ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Optical Coherence ◽  
Elevated Intraocular Pressure

scholarly journals Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure

2016 ◽  
Vol 73 (7) ◽  
pp. 618-625
Author(s):  
Marija Trenkic-Bozinovic ◽  
Gordana Zlatanovic ◽  
Predrag Jovanovic ◽  
Dragan Veselinovic ◽  
Jasmina Djordjevic-Jocic ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Optical Coherence ◽  
Open Angle ◽  
Significant Information ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
Elevated Intraocular Pressure

Background/Aim. Glaucoma is a progressive optic neuropathy characterized by damage of the retinal ganglion cells and their axons and glial cells. The aim of this study was to evaluate the differences and connections between changes in the visual field and the thickness of the peripapillary retinal nerve fiber layer (RNFL), using optical coherence tomography (OCT) in patients with primary open-angle glaucoma with normal and elevated intraocular pressure (IOP). Methods. This prospective study included 38 patients (38 eyes) with primary open-angle glaucoma with normal intraocular pressure (NTG) and 50 patients (50 eyes) with primary open-angle glaucoma with elevated intraocular pressure (HTG), paired by the same degree of structural glaucomatous changes in the optic nerve head and by age. OCT protocols ?fast RNFL thickness? and ?fast optic disc? were used for testing. The patients? age, gender, best corrected visual acuity (BCVA), IOP, stereometric and functional parameters were compared. Results. The average age of the examined population was 65.49 ? 9.36 (range 44-83) years. There was no statistically significant difference by age and by gender between the two study groups (p = 0.795 and p = 0.807, respectively). BCVA was higher in patients with NTG but there was no statistically significant difference compared to HTG patients (p = 0.160). IOP was statistically significantly higher in patients with HTG compared to NTG patients (17.40 ? 2.77 mmHg vs 14.95 ? 3.01 mmHg, p = 0.009). The cup/disc (C/D) (p = 0.258), mean deviation (MD) (p = 0.477), corrected patern standard deviation (CPSD) (p = 0.943), disk area (p = 0.515), rim area (p = 0.294), rim volume (p = 0.118), C/D area R (p = 0.103), RNFL Average (p = 0.632), RNFL Superior (p = 0.283) and RNFL Inferior (p = 0.488) were not statistically significantly different between the groups. Conclusion. OCT measurements of the RNFL thickness provide clinically significant information in monitoring of glaucomatous changes. There are no differences in the patterns of RNFL defects per sectors and quadrants between NTG and HTG, measured by OCT.

scholarly journals The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

2021 ◽  
Vol 10 (2) ◽  
pp. 231
Author(s):  
Giacinto Triolo ◽  
Piero Barboni ◽  
Giacomo Savini ◽  
Francesco De Gaetano ◽  
Gaspare Monaco ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Clinical Relevance ◽  
Anterior Segment ◽  
Angle Closure ◽  
Current Evidence ◽  
Optical Coherence ◽  
Iridocorneal Angle ◽  
Wide Range

The introduction of anterior-segment optical-coherence tomography (AS-OCT) has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly. The aim of the present review is to summarize the current evidence supporting the use of AS-OCT for the diagnosis and follow-up of several iridocorneal-angle and anterior-chamber alterations, focusing on the advantages and downsides of this technology.

scholarly journals Age-Related Changes in the Rhesus Macaque Eye

2021 ◽  
Author(s):  
Kira Lin ◽  
Tu Tran ◽  
Soohyun Kim ◽  
Sangwan Park ◽  
Jiajia Chen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Rhesus Macaque ◽  
Axial Length ◽  
Rhesus Macaques ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Lens Thickness ◽  
Age Related ◽  
Age Related Changes

Purpose: To assess age-related changes in the rhesus macaque eye and evaluate them to corresponding human age-related eye disease. Methods: Data from eye exams and imaging tests including intraocular pressure (IOP), lens thickness, axial length, and retinal optical coherence tomography (OCT) images were evaluated from 142 individuals and statistically analyzed for age-related changes. Quantitative autofluorescence (qAF) was measured as was the presence of macular lesions as related to age. Results: Ages of the 142 rhesus macaques ranged from 0.7 to 29 years (mean=16.4 years, stdev=7.5 years). Anterior segment measurements such as IOP, lens thickness, and axial length were acquired. Advanced retinal imaging in the form of optical coherence tomography and qAF were obtained. Quantitative assessments were made and variations by age groups were analyzed to compare with established age-related changes in human eyes. Quantitative analysis of data revealed age-related increase in intraocular pressure, ocular biometry (lens thickness and axial length), and presence of macular lesions. Age-related changes in thicknesses of retinal layers on OCT were observed and quantified. Age was correlated with increased qAF. Conclusions: The rhesus macaque has age-related ocular changes similar to humans. IOP increases with age while retinal ganglion cell layer thickness decreases. Macular lesions develop in some aged animals. Our findings support the concept that rhesus macaques may be useful for the study of important age-related diseases such as glaucoma, macular diseases, and cone disorders, and for development of therapies for these diseases.

Evaluation of Possible Changes in Intraocular Pressure and Optical Coherence Tomography Measurements in Severe OSAS Patients After 3 Month Positive Airway Pressure Treatment

2021 ◽  
Author(s):  
Nursel Dikmen ◽  
Ayse Idil Cakmak ◽  
Selma Urfalıoğlu
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Corneal Thickness ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Before And After ◽  
Sleep Parameters ◽  
Pre Treatment

Abstract Purpose: To identify and compare possible changes in intraocular pressure (IOP), macular and peripapillary retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) before and after 3 months of positive airway pressure (PAP) in patients with severe OSAS.Materials and Methods: Twenty-five patients diagnosed with severe OSAS in the neurology sleep outpatient clinic were included in the study. Ophthalmologic examinations were performed at the time of diagnosis and after 3 months of PAP treatment. Statistical analysis of comparisons of IOP and OCT measurements taken before and after PAP treatment was performed. Before treatment, the correlations between central corneal thickness (CCT), body mass index (BMI), OCT, IOP and sleep parameters were statistically investigated.Results: When comparisons were made for both eyes, after 3 months of PAP treatment, a statistically significant decrease in IOP, thickening of the macula, and thinning of RNFL in the superior nasal sector were found when compared with the measurements previously taken at the time of diagnosis (p <0.05). There was no correlation between pre-treatment IOP, OCT, CCT, BMI and sleep parameters.Discussion: The inflammatory effects of OSAS on the IOP and macula have been shown to be reversible with a 3-month PAP treatment, but the reversibility of the neurodegenerative effects of OSAS on RNFL with this treatment seems controversial. OCT is a promising technique for monitoring disease progression in patients with severe OSAS under PAP treatment.

Anterior chamber particles are associated with reduction of intraocular pressure after selective laser trabeculoplasty

2020 ◽  
pp. bjophthalmol-2019-315445
Author(s):  
Alexei N Kulikov ◽  
Dmitrii S Maltsev ◽  
Alina A Kazak ◽  
Maria A Burnasheva
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Selective Laser Trabeculoplasty ◽  
Cross Sectional ◽  
Laser Trabeculoplasty ◽  
The Mean

PurposeTo study the correlation between intraocular pressure (IOP) reduction and the number of hyper-reflective particles appearing in the anterior chamber following selective laser trabeculoplasty (SLT).Material and methodsIn this prospective interventional study, we included primary open-angle glaucoma patients. All participants received a standardised SLT session, which consisted of 100 pulses of 0.9 mJ over 360°. Anterior segment optical coherence tomography (4×4 mm volume scan, 101 horizontal cross-sectional scans) and applanation tonometry were performed before SLT and 15 min, 1 day, 1 week, 1 month and 3 months after. Particles were counted on cross-sectional scans using a standardised algorithm.ResultsIn this study, we included 25 patients (25 eyes), 14 males and 11 females, with a mean age of 68.9±10.5 and baseline IOP of 21.4±4.5 mm Hg. IOP at month 1 and month 3 after SLT was 18.0±4.0 and 17.4±3.3 mm Hg, respectively. The mean number of anterior chamber particles before and 15 min after SLT was 0.62±0.2 and 7.1±2.0 particles/mm2, respectively (p=0.036). There was a statistically significant correlation between the mean number of anterior chamber particles 15 min after SLT and IOP reduction at 1 month (r=0.62, p=0.03) and 3 months (r=0.71, p=0.01).ConclusionThe number of the anterior chamber particles graded using anterior segment optical coherence tomography after the procedure correlates with the IOP-lowering effect of SLT.

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