NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies

Nadph Cytochrome ◽

P450 Reductase ◽

Effect of Neurotransmitters on NADPH-Cytochrome P450 Reductase In Vitro Activity

Drug Metabolism Letters ◽

10.2174/187231207781369762 ◽

2007 ◽

Vol 1 (3) ◽

pp. 172-175 ◽

Cited By ~ 2

Author(s):

Guillermo Gervasini ◽

Carmen Martinez ◽

Julio Benitez ◽

Jose A.G. Agundez

Keyword(s):

Cytochrome P450 ◽

Vitro Activity ◽

In Vitro Activity ◽

Nadph Cytochrome ◽

P450 Reductase ◽

The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase

Chemico-Biological Interactions ◽

10.1016/j.cbi.2005.09.001 ◽

2006 ◽

Vol 159 (1) ◽

pp. 47-57 ◽

Cited By ~ 2

Author(s):

Shizuo Narimatsu ◽

Noriko Takatsu ◽

Shigeru Yamano ◽

Yusuke Inoue ◽

Nobumitsu Hanioka ◽

...

Keyword(s):

Cytochrome P450 ◽

Dimethyl Sulfoxide ◽

Hepg2 Cells ◽

Cytochrome P450 2D6 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase ◽

P450 2D6

Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

The cytochrome P450 2B4-NADPH cytochrome P450 reductase electron transfer complex is not formed by charge-pairing.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)42093-5 ◽

1992 ◽

Vol 267 (21) ◽

pp. 14669-14676

Author(s):

A.I. Voznesensky ◽

J.B. Schenkman

Keyword(s):

Electron Transfer ◽

Cytochrome P450 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Cytochrome P450 2B4 ◽

Nadph Cytochrome P450 Reductase ◽

Electron Transfer Complex

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

Anti-Cancer Drugs ◽

10.1097/cad.0b013e32834fcf4f ◽

2012 ◽

Vol 23 (4) ◽

pp. 393-405 ◽

Cited By ~ 5

Author(s):

Dorota Kostrzewa-Nowak ◽

Bohdan Bieg ◽

Mark J.I. Paine ◽

C. Roland Wolf ◽

Jolanta Tarasiuk

Keyword(s):

Cytochrome P450 ◽

Multidrug Resistant ◽

Structural Factors ◽

Hl60 Cells ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anthraquinone Derivatives ◽

Organization of NADPH-Cytochrome P450 Reductase and CYP1A2 in the Endoplasmic Reticulum—Microdomain Localization Affects Monooxygenase Function

Molecular Pharmacology ◽

10.1124/mol.110.068817 ◽

2010 ◽

Vol 79 (3) ◽

pp. 549-557 ◽

Cited By ~ 24

Author(s):

Lauren Brignac-Huber ◽

James R. Reed ◽

Wayne L. Backes

Keyword(s):

Endoplasmic Reticulum ◽

Cytochrome P450 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Role of the prosthetic groups of NADPH-cytochrome P450 reductase in 3-hydroxyanthranilamide-catalyzed, NADPH-dependent superoxide anion production

Redox Report ◽

10.1080/13510002.1996.11747070 ◽

1996 ◽

Vol 2 (5) ◽

pp. 339-344

Author(s):

Y. Ohta ◽

R. Shinohara ◽

I. Ishiguro

Keyword(s):

Cytochrome P450 ◽

Superoxide Anion ◽

Superoxide Anion Production ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anion Production ◽

Nadph Cytochrome P450 Reductase ◽

Prosthetic Groups

Reduction of cytochrome b5 by NADPH–cytochrome P450 reductase

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2005.06.019 ◽

2005 ◽

Vol 440 (2) ◽

pp. 204-211 ◽

Cited By ~ 56

Author(s):

F. Peter Guengerich

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2010.08.072 ◽

2010 ◽

Vol 400 (3) ◽

pp. 374-378 ◽

Cited By ~ 26

Author(s):

Amit V. Pandey ◽

Christa E. Flück ◽

Primus E. Mullis

Keyword(s):

Cytochrome P450 ◽

Heme Oxygenase ◽

Heme Oxygenase 1 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Membrane Topology of NADPH–Cytochrome P450 Reductase on the Endoplasmic Reticulum

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.1997.0553 ◽

1998 ◽

Vol 351 (2) ◽

pp. 175-179 ◽

Cited By ~ 22

Author(s):

Yuichiro Kida ◽

Satoru Ohgiya ◽

Katsuyoshi Mihara ◽

Masao Sakaguchi

Keyword(s):

Endoplasmic Reticulum ◽

Cytochrome P450 ◽

Membrane Topology ◽

Nadph Cytochrome ◽

P450 Reductase ◽