Robust stochastic multi-choice goal programming for blood collection and distribution problem with real application

Blood Supply Chain (BSC) concerns with flow of blood products from blood collection by donors to transfusion of blood components to patients. BSC comprises of collection, testing, processing, storage, distribution and transfusion activities, which are normally responsibility of Blood Centre and hospitals. In Malaysia, National Blood Centre (PDN) is responsible to organize blood donation, collection and processing. Current procedure practised by PDN is to have vehicles sending staffs and equipment while one vehicle is assigned to collect donated blood from donation sites and transport the blood to PDN within six hours. As consequence, vehicles shortages are encountered and resources optimization unachieved especially when many blood donation sites involved per day. This paper presents the results of a preliminary study which aims at proposing blood collection optimal routes for blood collecting vehicles that adhere to all pre-determined time windows for blood collection at blood donation sites. A Mixed Integer Goal Programming (MIGP) model based on Vehicle Routing Problem with Time Windows (VRPTW) has been formulated. The MIGP model pursues four goals, namely, to minimize total distance travelled, to minimize total travel time, to minimize total waiting time of vehicles and to minimize number of vehicles (routes). The model was solved using preemptive goal programming approach and existing heuristics for the VRPTW. Based on the results, it can be concluded that the donated blood can be collected and transported using reduced number of vehicles as proposed by the MIGP model’s optimal compared to the total number of vehicles used by current practice, Thus, the proposed VRPTW based MIGP model has promising significant impact for donated blood transportation in terms of resources optimization and costs savings. The model and approach could be easily extended to solve larger problem involving large number of donation sites with variants of time windows for the sites.

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Stability of antioxidant vitamins in whole human blood during overnight storage at 4°C and frozen storage up to 6 months

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000485 ◽

2018 ◽

Vol 88 (3-4) ◽

pp. 151-157 ◽

Cited By ~ 3

Author(s):

Scott W. Leonard ◽

Gerd Bobe ◽

Maret G. Traber

Keyword(s):

Ascorbic Acid ◽

Whole Blood ◽

Healthy Subjects ◽

Frozen Storage ◽

Blood Collection ◽

Plasma Samples ◽

Optimal Conditions ◽

Plasma Ascorbic Acid ◽

Blood Samples ◽

Sample Handling

Abstract. To determine optimal conditions for blood collection during clinical trials, where sample handling logistics might preclude prompt separation of erythrocytes from plasma, healthy subjects (n=8, 6 M/2F) were recruited and non-fasting blood samples were collected into tubes containing different anticoagulants (ethylenediaminetetra-acetic acid (EDTA), Li-heparin or Na-heparin). We hypothesized that heparin, but not EDTA, would effectively protect plasma tocopherols, ascorbic acid, and vitamin E catabolites (α- and γ-CEHC) from oxidative damage. To test this hypothesis, one set of tubes was processed immediately and plasma samples were stored at −80°C, while the other set was stored at 4°C and processed the following morning (~30 hours) and analyzed, or the samples were analyzed after 6 months of storage. Plasma ascorbic acid, as measured using HPLC with electrochemical detection (LC-ECD) decreased by 75% with overnight storage using EDTA as an anticoagulant, but was unchanged when heparin was used. Neither time prior to processing, nor anticoagulant, had any significant effects upon plasma α- or γ-tocopherols or α- or γ-CEHC concentrations. α- and γ-tocopherol concentrations remained unchanged after 6 months of storage at −80°C, when measured using either LC-ECD or LC/mass spectrometry. Thus, refrigeration of whole blood at 4°C overnight does not change plasma α- or γ-tocopherol concentrations or their catabolites. Ascorbic acid is unstable in whole blood when EDTA is used as an anticoagulant, but when whole blood is collected with heparin, it can be stored overnight and subsequently processed.

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The use of goal programming and data envelopment analysis for estimating efficient marginal costs of outputs

Journal of the Operational Research Society ◽

10.1038/sj.jors.2600376 ◽

1997 ◽

Vol 48 (3) ◽

pp. 319-323 ◽

Cited By ~ 1

Author(s):

D Giokas

Keyword(s):

Data Envelopment Analysis ◽

Goal Programming ◽

Data Envelopment ◽

Marginal Costs

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Goal programming, compromise programming and reference point method formulations: linkages and utility interpretations

Journal of the Operational Research Society ◽

10.1038/sj.jors.2600611 ◽

1998 ◽

Vol 49 (9) ◽

pp. 986-991 ◽

Cited By ~ 2

Author(s):

C Romero ◽

M Tamiz ◽

D F Jones

Keyword(s):

Goal Programming ◽

Reference Point ◽

Compromise Programming ◽

Point Method ◽

Reference Point Method

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1-Desamino-8-D-Arginine Vasopressin (DDAVP) Infusion in Type IIB von Willebrand’s Disease: Shortening of Bleeding Time and Induction of a Variable Pseudothrombocytopenia

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647265 ◽

1990 ◽

Vol 64 (01) ◽

pp. 117-120 ◽

Cited By ~ 22

Author(s):

Alessandra Casonato ◽

M Teresa Sartori ◽

Luigi de Marco ◽

Antonio Girolami

Keyword(s):

Monoclonal Antibody ◽

Platelet Count ◽

Arginine Vasopressin ◽

Calcium Concentration ◽

Sodium Citrate ◽

Bleeding Time ◽

Blood Collection ◽

Von Willebrand's Disease ◽

Blood Samples ◽

Von Willebrand’S Disease

SummaryWe have investigated the effects of 1-desamino-8-D-arginine vasopressin (DDAVP) infusion on platelet count and bleeding time in 4 patients with type IIB von Willebrand’s disease (vWd). Three of four patients showed a normalization of the bleeding time within 1 h after the infusion, while bleeding time was not modified in the fourth. In accordance with the literature, thrombocytopenia was observed after DDAVP infusion, but this thrombocytopenia was due to the anticoagulants used for blood collection. In two patients (F. I., G. F.) no thrombocytopenia was observed when platelets were counted by fingerstick method but there was a 20% platelet decrease in blood samples collected in sodium citrate and a 50% decrease in samples collected in EDTA. Dramatic falls in platelet counts (70–95%) were observed in the additional two patients (C. A., D.Z.) after DDAVP infusion, when both sodium citrate or EDTA were used as anticoagulants. In the latter two patients there was also a 50% decrease in platelet count when the fingerstick method was used. The decrease in the patient’s platelet count in EDTA samples after DDAVP infusion could be prevented, in part, by the previous additions of an anti GPIb monoclonal antibody and an anti GPIIb-IIIa monoclonal antibody.Thus, the thrombocytopenia observed in the four IIB vWd patients studied after DDAVP infusion seems to be, at least partially, a pseudothrombocytopenia depending on the calcium concentration in the blood samples and the availability of GPIb and GPIIb-IIIa receptors. These findings and the normalization of the bleeding time observed in three of the four patients has led us to reconsider the possible use of DDAVP in the treatment of our IIB vWd patients.

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