With the rapid development of logistics enterprises, personnel decision management of logistics enterprise is highly valued by the relevant institutions and enterprises. How to correctly understand the core function of logistics enterprises, mining and build the core talent decision support system is one of the topics in this field to be solved. Firstly, based on the talent incentive model, we analyze the talent incentive process of logistics enterprise, and based on the characteristics of cloud database we construct personnel decision support system of logistics enterprise. In order to verify the practicality of the system, we use computer simulation to simulate the system. The results show that the system has practical strong, and ability of scientific decision-making is better.