Does steady state serum level of Valproic acid correlate with dose, seizure response and frequency of adverse drug reactions in Pakistani children with epilepsy?

2015 ◽  
Vol 09 (03) ◽  
pp. 333-339
Author(s):  
Muhammad Rana ◽  
Abdul Sattar ◽  
Imran Iqbal ◽  
Nuzhat Noureen
Keyword(s):  
Valproic Acid ◽  
Steady State ◽  
Serum Level ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Steady State Serum

Seizure and Toxic Epidermal Necrolysis with Fluoroquinolone; Another Case of TEN with Levofloxacin; Neurotoxicity with Unexpected High Levels of Free Valproic Acid; Acute Clonidine Withdrawal Leads to an Acute Myocardial Infarction; Hepatotoxicity and Hepatorenal Toxicity with SSRIs; Serotonin Toxicity Associated with Linezolid; The RADAR Project – Research on Adverse Drug Events and Reports; Nonadherence Causes Problems!

2005 ◽  
Vol 40 (8) ◽  
pp. 650-657 ◽  
Author(s):  
Joel Shuster
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Valproic Acid ◽  
Toxic Epidermal Necrolysis ◽  
Adverse Drug Reactions ◽  
Adverse Drug Events ◽  
Drug Reactions ◽  
Clonidine Withdrawal ◽  
Serotonin Toxicity

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), to discuss methods of prevention, and to promote reporting of ADRs to the FDA's medWatch program (800-FDA-1088). If you have reported an interesting preventable ADR to medWatch, please consider sharing the account with our readers.

Adverse drug reactions induced by valproic acid

2013 ◽  
Vol 46 (15) ◽  
pp. 1323-1338 ◽  
Author(s):  
Radu M. Nanau ◽  
Manuela G. Neuman
Keyword(s):  
Valproic Acid ◽  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals AS3MT Polymorphism: A Risk Factor for Epilepsy Susceptibility and Adverse Drug Reactions to Valproic Acid and Oxcarbazepine Treatment in Children From South China

2021 ◽  
Vol 15 ◽  
Author(s):  
Xiaomei Fan ◽  
Yuna Chen ◽  
Jieluan Lu ◽  
Wenzhou Li ◽  
Xi Li ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Adverse Drug Reactions ◽  
South China ◽  
Target Genes ◽  
Pediatric Epilepsy ◽  
Drug Reactions ◽  
Intractable Seizures ◽  
Genotypic Analysis ◽  
Epileptic Children ◽  
Chinese Cohort

Epilepsy is a common neurologic disorder characterized by intractable seizures, involving genetic factors. There is a need to develop reliable genetic markers to predict the risk of epilepsy and design effective therapies. Arsenite methyltransferase (AS3MT) catalyzes the biomethylation of arsenic and hence regulates arsenic metabolism. AS3MT variation has been linked to the progression of various diseases including schizophrenia and attention deficit or hyperactivity disorder. Whether genetic polymorphism of AS3MT contributes to epilepsy remains unclear. In this study, we investigated the association of AS3MT gene polymorphism with susceptibility to epilepsy in children from south China. We also explored the effect of AS3MT variation on the safety of antiepileptic drugs. Genotypic analysis for AS3MT rs7085104 was performed using samples from a Chinese cohort of 200 epileptic children and 244 healthy individuals. The results revealed a genetic association of AS3MT rs7085104 with susceptibility to pediatric epilepsy. Mutant homozygous GG genotype exhibited a lower susceptibility to childhood epilepsy than AA genotype. Carriers of AS3MT rs7085104 AA genotype exhibited a higher risk of digestive adverse drug reactions (dADRs) in children when treated with valproic acid (VPA) or oxcarbazepine (OXC). Additionally, bioinformatics analysis identified eight AS3MT target genes related to epilepsy and three AS3MT-associated genes in VPA-related dADRs. The effects of AS3MT on epilepsy might involve multiple targets including CNNM2, CACNB2, TRIM26, MTHFR, GSTM1, CYP17A1, NT5C2, and YBX3. This study reveals that AS3MT may be a new gene contributing to epileptogenesis. Hence, analysis of AS3MT polymorphisms will help to evaluate susceptibility to pediatric epilepsy and drug safety.

scholarly journals Effect of Genetic Polymorphisms of CYP2C19 on the Steady-state Serum Concentrations of Valproic Acid in Chinese Han Patients With Schizophrenia

2020 ◽  
Author(s):  
Shengdong WANG ◽  
Jing Li ◽  
Mingfen Song ◽  
Pan Yan ◽  
Xuan Ju ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Steady State ◽  
Genetic Polymorphisms ◽  
Fixed Dose ◽  
Serum Concentrations ◽  
Chinese Han ◽  
Chromatography Method ◽  
Steady State Serum ◽  
The Mean ◽  
Mean Concentration

Abstract Valproic acid is an anticonvulsant, which is also widely used for treating psychiatric disorders. Some clinical trials have demonstrated benefits of valproic acid augmentation therapy in schizophrenia. Interindividual variability in valproic acid dose and serum concentration may reflect functional consequences of genetic polymorphisms in genes encoding drug-metabolizing enzymes. The aim of this study was to determine the relationship between serum concentrations of valproic acid and single nucleotide polymorphisms of the cytochrome P450 (CYP) 2C19 gene in patients with schizophrenia. All patients had been receiving fixed dose of valproic acid for at least 2 weeks. The daily doses were 0.5–1.5 g. No other drugs except olanzapine were coadministered. Serum concentrations of valproic acid were measured using the ultra-high performance liquid chromatography method with mass-spectrometric detection. The CYP2C19 (CYP2C19*2 G681A and CYP2C19*3 G636A) genotypes were identified by real-time PCR analyses. The mean concentration/dose ratios of valproic acid was significantly higher in patients with 1 (P = 0.029) or 2 (P = 0.007) mutated alleles for CYP2C19 than in those without mutated alleles. The mean concentration/dose ratios of valproic acid was significantly higher in patients with CYP2C19 *1/*2 genotype (P = 0.029) or CYP2C19 *2/*3 genotype (P = 0.014) than in those with CYP2C12 *1/*1 genotype. The findings of this study suggest that CYP2C19 genotypes play an important role in controlling steady-state serum concentrations of valproic acid in Chinese Han population.

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