INFLUENCE OF AGE AND CONCURRENT MEDICATION ON STEADY-STATE VALPROIC ACID SERUM LEVEL-DOSE RATIOS IN JAPANESE PAEDIATRIC PATIENTS

1991 ◽  
Vol 16 (4) ◽  
pp. 291-297 ◽  
Author(s):  
E. Yukawa ◽  
A. Suzuki ◽  
S. Higuchi ◽  
T. Aoyama
Keyword(s):  
Valproic Acid ◽  
Steady State ◽  
Serum Level ◽  
Paediatric Patients ◽  
Concurrent Medication

Steady-state kinetics of valproic acid in epileptic patients

1978 ◽  
Vol 24 (3) ◽  
pp. 324-332 ◽  
Author(s):  
J. Bruni ◽  
B. J. Wilder ◽  
L. J. Willmore ◽  
R. J. Perchalski ◽  
H. J. Villarreal
Keyword(s):  
Valproic Acid ◽  
Steady State ◽  
Steady State Kinetics ◽  
Epileptic Patients ◽  
Kinetics Of

scholarly journals Inflammatory mediators in sickle cell anaemia highlight the difference between steady state and crisis in paediatric patients

2017 ◽  
Vol 182 (6) ◽  
pp. 933-936 ◽  
Author(s):  
Magda O. S. Carvalho ◽  
Théo Araujo-Santos ◽  
João H. O. Reis ◽  
Larissa C. Rocha ◽  
Bruno A. V. Cerqueira ◽  
...  
Keyword(s):  
Steady State ◽  
Sickle Cell ◽  
Inflammatory Mediators ◽  
Sickle Cell Anaemia ◽  
Paediatric Patients ◽  
The Difference

SERUM CONCENTRATIONS OF GONADOTROPHINS AND THE HYPOTHALAMIC CONTENT OF GONADOTROPHIN RELEASING HORMONE IN MALE RATS EXPOSED TO 35 °C

1980 ◽  
Vol 84 (1) ◽  
pp. 9-16 ◽  
Author(s):  
E. BEDRAK ◽  
Z. CHAP
Keyword(s):  
Steady State ◽  
Serum Level ◽  
Histological Examination ◽  
Heat Exposure ◽  
Male Rats ◽  
Serum Concentrations ◽  
Releasing Hormone ◽  
Gonadotrophin Releasing Hormone ◽  
Temporary Decrease

Serum concentrations of FSH and LH and the hypothalamic content of gonadotrophin releasing hormone (GnRH) were measured by radioimmunoassay in male rats maintained at 35 °C for various periods of time. The results show that heat exposure caused a temporary decrease in serum concentrations of LH and FSH which was associated with comparable changes in the hypothalamic content of GnRH. Histological examination of the adenohypophysis of rats exposed to heat for 42 days disclosed that the gonadotrophs underwent hypertrophy and hyperplasia and appeared more active than those of control rats. The data suggest that in rats exposed to heat for prolonged periods a new steady-state is established through which an adequate serum level of LH is maintained.

A Multivariable Analysis of Factors Governing the Steady-State Pharmacokinetics of Valproic Acid in 52 Young Epileptics

1985 ◽  
Vol 25 (4) ◽  
pp. 261-268 ◽  
Author(s):  
K. Hall ◽  
N. Otten ◽  
B. Johnston ◽  
J. Irvine-Meek ◽  
M. Leroux ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Steady State ◽  
Multivariable Analysis

scholarly journals Paediatric population pharmacokinetic and pharmacodynamic modelling of ambrisentan in pulmonary arterial hypertension and comparison with adult data

2021 ◽  
Author(s):  
Malek Okour ◽  
Mita Thapar ◽  
Colm Farrell ◽  
Mary Ann Lukas ◽  
Maurice Beghetti ◽  
...  
Keyword(s):  
Body Weight ◽  
Steady State ◽  
Adult Population ◽  
Systemic Exposure ◽  
Paediatric Population ◽  
Walking Distance ◽  
Population Pharmacokinetic ◽  
Paediatric Patients ◽  
Population Pk ◽  
Pulmonary Arterial

Aims: To develop a population pharmacokinetic (PK) model of ambrisentan in paediatric patients aged 8 to <18 years with pulmonary arterial hypertension (PAH), compare paediatric ambrisentan systemic exposure to historical adult data, and assess PK–PD relationships. Methods: A previously developed adult population PK model provided an initial step for modelling the 211 PK observations from 39 paediatric patients with PAH in the randomised Phase IIb study AMB112529 (NCT01332331). Subsequently, a population PK model was developed using only paediatric PK data. Steady-state systemic exposure metrics were estimated for the paediatric population and compared with historical adult data (adult patients with PAH and healthy volunteers). Exploratory exposure–response analysis assessed ambrisentan systemic exposure versus change from baseline in 6-minute walking distance in paediatric patients; findings were compared with adult data. An exploratory analysis of ambrisentan exposure versus incidence of ambrisentan-related adverse events in paediatric patients was also performed. Results: The final paediatric population PK model was a two-compartment model which includes the effect of body weight (allometric scaling), first-order absorption and elimination, and absorption lag time. Similar steady-state ambrisentan exposure was confirmed in paediatric patients and historical adult data when differences in body weight were accounted for. There was no apparent correlation in the paediatric or adult population between ambrisentan exposure and change in 6-minute walking distance, or between ambrisentan exposure and incidence of ambrisentan-related adverse events in paediatric patients. Conclusions: Similar ambrisentan exposure and PK–PD profiles were observed in paediatric and adult populations with PAH.

scholarly journals Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children

2019 ◽  
Vol 3 (1) ◽  
pp. 42
Author(s):  
I Gusti Ngurah Made Suwarba ◽  
Ni Putu Yunik Novayanti ◽  
I Gusti Lanang Sidiartha ◽  
Dewi Sutriani Mahalini
Keyword(s):  
Valproic Acid ◽  
Serum Level ◽  
Negative Correlation ◽  
Vitamin B6 ◽  
Active Form ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Acid Therapy ◽  
Valproic Acid Therapy ◽  
Weak Negative Correlation

Background: It is important to maintain the adequate level of vitamin B6 to ensure stable metabolism. Vitamin B6 serum level might decreased by absorption disturbance or increasing demand. Valproic acid increase the synthesis of serum GABAergic in the other hand vitamin B6 is required as cofactor for gamma-amino butyric acid (GABA) formation. The dosage and duration of valproic acid therapy might be correlated with vitamin B6 serum level. The aim of this study is to know the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy in children with epilepsy.Materials and Methods: This is a cross sectional study to investigate the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy. The level of vitamin B6 serum was determined by checking vitamin B6 active form in serum, pyridoxal 5’-phospate (PLP).Results: In this study, 37 epilepsy children with valproic acid duration therapy more than 3 months was enrolled. Fifty six percent epilepsy children were male, commonly on children age 1-5 years old. Spearman correlation coefficient test showed a significant weak negative correlation between vitamin B6 serum level and dosage of valproic acid (r=–0.35; p=0.03), and very weak negative correlation with valproic acid duration therapy (r=-0.08; p=0.59), however it was not significant. Conclusion: There was a significant weak negative correlation between vitamin B6 serum level and very weak negative correlation with valproic acid duration therapy, but not significant in children with epilepsy.Keywords: correlation, valproic acid, vitamin B6

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