Universal Protein Resource

2020 ◽  
Author(s):  
Keyword(s):  
Universal Protein

scholarly journals A review of the current understanding of nanoparticles protein corona composition

2020 ◽  
Author(s):  
Pranvera Breznica ◽  
Rozafa Koliqi ◽  
Arlinda Daka
Keyword(s):  
Protein Binding ◽  
Exposure Time ◽  
Protein Corona ◽  
Current Understanding ◽  
Biological Medium ◽  
Chemical Characteristics ◽  
Physical And Chemical Characteristics ◽  
Different Types ◽  
Physical And Chemical ◽  
Universal Protein

Upon entering into the biological environments, the surface of the nanoparticles is immediately coated with proteins and form the so-called a protein corona due to which a nanoparticle changes its "synthetic" identity to a new "biological" identity. Different types of nanoparticles have different protein binding profiles, which is why they have different protein corona composition and therefore it cannot be said that there is a universal protein corona. The composition and amount of protein in the corona depends on the physical and chemical characteristics of the nanoparticles, the type of biological medium and the exposure time. Protein corona increases the diameter but also changes the composition of the surface of the nanoparticles and these changes affect biodistribution, efficacy, and toxicity of the nanoparticles.

The Ribosome—the Universal Protein-synthesizing Machine

1998 ◽  
pp. 41-IV
Author(s):  
Richard Brimacombe
Keyword(s):  
Universal Protein

scholarly journals Activities at the Universal Protein Resource (UniProt)

2013 ◽  
Vol 42 (D1) ◽  
pp. D191-D198 ◽  
Keyword(s):  
Universal Protein

scholarly journals Universal protein distributions in a model of cell growth and division

2015 ◽  
Vol 92 (4) ◽  
Author(s):  
Naama Brenner ◽  
C. M. Newman ◽  
Dino Osmanović ◽  
Yitzhak Rabin ◽  
Hanna Salman ◽  
...  
Keyword(s):  
Cell Growth ◽  
Universal Protein

Photophysical Studies on the Interaction of Acridinedione Dyes with Universal Protein Denaturant: Guanidine Hydrochloride

2010 ◽  
Vol 20 (5) ◽  
pp. 993-1002 ◽  
Author(s):  
R. Kumaran ◽  
T. Varalakshmi ◽  
E. J. Padma Malar ◽  
P. Ramamurthy
Keyword(s):  
Guanidine Hydrochloride ◽  
Photophysical Studies ◽  
Acridinedione Dyes ◽  
Protein Denaturant ◽  
Universal Protein

UniprotR: Retrieving and visualizing protein sequence and functional information from Universal Protein Resource (UniProt knowledgebase)

2020 ◽  
Vol 213 ◽  
pp. 103613 ◽  
Author(s):  
Mohamed Soudy ◽  
Ali Mostafa Anwar ◽  
Eman Ali Ahmed ◽  
Aya Osama ◽  
Shahd Ezzeldin ◽  
...  
Keyword(s):  
Protein Sequence ◽  
Functional Information ◽  
Universal Protein

scholarly journals Design Principles of a Universal Protein Degradation Machine

2013 ◽  
Vol 425 (2) ◽  
pp. 199-213 ◽  
Author(s):  
Mary E. Matyskiela ◽  
Andreas Martin
Keyword(s):  
Protein Degradation ◽  
Design Principles ◽  
Universal Protein

scholarly journals Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLC/Q-TOF-MS and Network Pharmacology

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Xianghui Ma ◽  
Bin Lv ◽  
Pan Li ◽  
Xiaoqing Jiang ◽  
Qian Zhou ◽  
...  
Keyword(s):  
Drug Absorption ◽  
Heart Diseases ◽  
Network Pharmacology ◽  
Chemical Compositions ◽  
Active Components ◽  
Multiple Targets ◽  
Multiple Components ◽  
Main Components ◽  
Tof Ms ◽  
Universal Protein

Naoxintong capsule (NXT) is a commercial medicinal product approved by the China Food and Drug Administration which is used in the treatment of stroke and coronary heart disease. However, the research on the composition and mechanism of NXT is still lacking. Our research aimed to identify the absorbable components, potential targets, and associated pathways of NXT with network pharmacology method. We explored the chemical compositions of NXT based on UPLC/Q-TOF-MS. Then, we used the five principles of drug absorption to identify absorbable ingredients. The databases of PharmMapper, Universal Protein, and the Molecule Annotation System were used to predict the main targets and related pathways. By the five principles of drug absorption as a judgment rule, we identified 63 compositions that could be absorbed in the blood in all 81 chemical compositions. Based on the constructed networks by the significant regulated 123 targets and 77 pathways, the main components that mediated the efficacy of NXT were organic acids, saponins, and tanshinones. Radix Astragali was the critical herbal medicine in NXT, which contained more active components than other herbs and regulated more targets and pathways. Our results showed that NXT had a therapeutic effect on heart diseases through the pattern “multiple components-multiple targets-multiple pathways.”

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