scholarly journals Prostatic Epithelium

2020 ◽  
Author(s):  
Keyword(s):  
Prostatic Epithelium

1428: Influence of Prostatic Epithelium on Proliferation and Differentiation of Stromal Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 387-387
Author(s):  
Quan Wu ◽  
Jian-Dang Shi ◽  
Yu Liu ◽  
Ke-Ming Wang ◽  
Helmut Klocker ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Proliferation And Differentiation ◽  
Prostatic Epithelium

Age-dependent changes in the carbohydrate pattern of human prostatic epithelium as determined by peroxidase-labeled lectins

The Prostate ◽  
1982 ◽  
Vol 3 (5) ◽  
pp. 507-513 ◽  
Author(s):  
Wolfgang Bischof ◽  
Gerhard Aumüller
Keyword(s):  
Age Dependent ◽  
Prostatic Epithelium

The Action of Diethylstilboestrol on the Prostatic Epithelium of the Mouse

1947 ◽  
Vol s3-88 (1) ◽  
pp. 45-53
Author(s):  
E. S. HORNING
Keyword(s):  
Golgi Apparatus ◽  
Inbred Strain ◽  
Normal Condition ◽  
Morphological Changes ◽  
Anterior Lobe ◽  
Cellular Changes ◽  
Prostatic Epithelium

1. The cellular changes in the prostatic epithelium of an inbred strain of mice (R III), following short periods of treatment with large doses of oestrogen, are described. 2. The Golgi apparatus in the cells of the prostatic epithelium affords a precise indication of the degree of stimulation induced by oestrogenic substances. 3. Specific morphological changes in the Golgi substance occur in the epithelium of the anterior lobe of the prostate after 8 days' treatment. Similar changes, following longer periods of treatment, also occur in the dorsal and ventral lobes. 4. Withdrawal of oestrogenic stimulation after 20 days' treatment with relatively large doses is followed by a return of the prostatic epithelium and the Golgi apparatus to their normal condition in 21 days.

scholarly journals QUANTITATIVE STUDIES OF PROSTATIC SECRETION

1953 ◽  
Vol 97 (5) ◽  
pp. 663-680 ◽  
Author(s):  
Charles Huggins ◽  
John Lambert Sommer
Keyword(s):  
Structural Changes ◽  
Testosterone Propionate ◽  
Estrogenic Activity ◽  
Submaxillary Gland ◽  
Critical Factors ◽  
Simple Arithmetic ◽  
Estrogenic Compounds ◽  
Submaxillary Glands ◽  
Quantitative Studies ◽  
Prostatic Epithelium

The prostate of the dog was relocated permanently in the perineum where its size could be measured and correlated with the output of prostatic secretion during many months. The secretion of a submaxillary gland obtained through a fistula was utilized as an internal biologic standard of the effects of pilocarpine, the secretory stimulus employed, because the amount and route of administration of the alkaloid are critical factors in inducing secretion. Prostatic secretion was found to be profoundly affected by androgenic and estrogenic compounds, in contrast to salivation. The curves of the secretory response of the prostate and submaxillary glands to pilocarpine proved to be similar and a mathematical formula has been constructed to represent them. When testosterone propionate was administered in increasing quantities for periods of weeks at each level, the volume of the prostate increased in a series of flattened curves. This volume, under the conditions mentioned, was found to stand in a simple arithmetic relationship to the amount of testosterone propionate administered. Moderate quantities of testosterone propionate masked the effects of small amounts of stilbestrol on the prostate. The reverse was also true and the critical amounts of these compounds were defined. The amounts of stilbestrol were determined which lowered the quantity of prostatic secretion resulting from the simultaneous administration of moderate amounts of testosterone propionate in castrate dogs, the result being a level and flat secretory curve which was maintained for many weeks. We designate this effect the plateau phenomenon. When this amount of estrogen was continued, and the dosage of testosterone propionate greatly augmented, the prostatic secretion did not increase in volume. Very slight increases above the critical amount of stilbestrol, however, caused the secretory curve to fall to new and still lower levels though the secretion was never completely suppressed. The acid phosphatase content of the prostatic secretion in the regions of secretory plateaus was similar to that of castrate dogs injected with androgen alone. The plateau phenomenon is due to simultaneous physiologic action of androgenic and estrogenic compounds on the prostatic cells. The depression of prostatic secretion resulting in the plateau phenomenon is due to both functional and structural changes in the prostatic epithelium. They are best explained on the assumption that differences in steroid threshold exist in groups of cells within the prostate, those of the anterior rim of the gland being least susceptible to estrogenic activity.

Histochemical and structural study of inflammatory growths of the prostatic epithelium

1969 ◽  
Vol 68 (4) ◽  
pp. 1183-1186
Author(s):  
A. G. Ginovker
Keyword(s):  
Structural Study ◽  
Prostatic Epithelium

scholarly journals Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex

2000 ◽  
Vol 24 (3) ◽  
pp. 339-351 ◽  
Author(s):  
AS Waller ◽  
RM Sharrard ◽  
P Berthon ◽  
NJ Maitland
Keyword(s):  
Androgen Receptor ◽  
In Vitro Models ◽  
Human Prostate ◽  
Intracellular Targeting ◽  
Natural Ligand ◽  
Prostate Cells ◽  
Established Cell ◽  
Prostatic Epithelium ◽  
Prostate Epithelium

In vitro models of normal and malignant human prostate are currently limited to a few well established cell lines that, with a single exception (LNCaP), fail to express the androgen receptor (AR) - a common characteristic of prostatic epithelium grown in culture. To investigate the molecular mechanism of action of the non-steroidal antiandrogen Casodex (bicalutamide) against wild-type AR, we have established a transient AR expression model in non-tumorigenic prostate cells of both epithelial and mesenchymal origin. In this model, both dihydrotestosterone and Casodex can effectively transport the AR protein into the nucleus of prostate cells. Whereas the natural ligand, dihydrotestosterone, stabilises the receptor, the AR is rapidly degraded at a nuclear location when the transfected cells are treated with Casodex. In contrast, whereas the mutant AR in the LNCaP line is also degraded on Casodex treatment over the same time period, its intracellular targeting is defective.

Characterization of cytoplasmic secretory granules (PSG), in prostatic epithelium and their transformation-induced loss in dysplasia and adenocarcinoma

1998 ◽  
Vol 29 (12) ◽  
pp. 1488-1494 ◽  
Author(s):  
Ronald J Cohen ◽  
John E McNeal ◽  
Stephen G Edgar ◽  
Terry Robertson ◽  
Hugh J.S Dawkins
Keyword(s):  
Secretory Granules ◽  
Prostatic Epithelium

MITOTIC ACTIVITY OF PROSTATIC EPITHELIUM

2009 ◽  
Vol 73 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Ivar Liavåg
Keyword(s):  
Mitotic Activity ◽  
Prostatic Epithelium

Bisphenol A induces permanent squamous change in mouse prostatic epithelium

2007 ◽  
Vol 75 (8) ◽  
pp. 745-756 ◽  
Author(s):  
Yuji Ogura ◽  
Kenichiro Ishii ◽  
Hideki Kanda ◽  
Masahiro Kanai ◽  
Kiminobu Arima ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Prostatic Epithelium
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